An industry perspective on the role and utility of animal models of pain in drug discovery.

abstract：:Adjacent serial sections of the organum vasculosum laminal terminalis (OVLT) of the rat were incubated with antisera of luteinizing-hormone--releasing-hormone (LH-RH) and somatostatin and stained by the peroxidase-antiperoxidase technique. The distribution patterns of the two oligopeptides show distinct differences, a...

journal_title：Neuroscience letters

authors： Krause R

更新日期：1979-02-01 00:00:00

abstract：:It has been shown that the incidence of cognitive impairment increases with the severity of chronic kidney disease (CKD). A previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in CKD model mice. Endoplasmic reticulum (ER) stress is thought to contribute significantly ...

journal_title：Neuroscience letters

authors： Kosuge Y,Osada N,Shimomura A,Miyagishi H,Wada T,Ishige K,Shimba S,Ito Y

更新日期：2018-06-11 00:00:00

abstract：:Self-initiated leg movement in standing humans is preceded by a medio-lateral preparatory balance adjustment (PBA); however, such preparatory balance control is often absent in reflex-like stepping responses evoked by whole-body instability. The presence or absence of the PBA may reflect a task-dependent modulation of...

journal_title：Neuroscience letters

authors： McIlroy WE,Bent LR,Potvin JR,Brooke JD,Maki BE

更新日期：1999-06-04 00:00:00

abstract：:The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with re...

journal_title：Neuroscience letters

authors： Bellido I,Díaz-Cabiale Z,Jiménez-Vasquez PA,Andbjer B,Mathé AA,Fuxe K

更新日期：2002-01-11 00:00:00

abstract：:Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is one of the most common forms of autosomal recessive cerebellar ataxia. We identified six new alternative transcripts produced by the aprataxin gene responsible for EAOH. Total eight transcripts encoded truncated proteins that were located withi...

journal_title：Neuroscience letters

authors： Hirano M,Nishiwaki T,Kariya S,Furiya Y,Kawahara M,Ueno S

更新日期：2004-08-12 00:00:00

abstract：:The Heat Shock Factors (HSFs) have been historically identified as a family of transcription factors that are activated and work in a stress-responsive manner, after exposure to a large variety of stimuli. However, they are also critical in normal conditions, in a life long manner, in a number of physiological process...

journal_title：Neuroscience letters

authors： Duchateau A,de Thonel A,El Fatimy R,Dubreuil V,Mezger V

更新日期：2020-04-23 00:00:00

abstract：:Quantitative neurophysiological studies have identified the presence of at least two spinal neuron populations (ABRUPT and SUSTAINED) which are excited by the noxious visceral stimulus colorectal distension (CRD). The present study examined the effects of acute colorectal inflammation on the activity of dorsal horn ne...

journal_title：Neuroscience letters

authors： Ness TJ,Gebhart GF

更新日期：2000-03-10 00:00:00

abstract：:Previous studies established that glutamate decarboxylase (GAD) is present in the brain of higher vertebrates in two forms composed of the homodimeric association of two subunits 59 and 63 kDa, respectively, that were found to be structurally related. We have performed quantitative comparative immunoblotting of whole ...

journal_title：Neuroscience letters

authors： Henry S,Tappaz M

更新日期：1991-10-14 00:00:00

abstract：:The mouse model of transcranial permanent occlusion of the middle cerebral artery (tpMCAO) is widely used in stroke research. Here we quantified infarct size using a conventional histological method at several post-ischaemic times, going beyond the commonly analysed period of up to 2 days, following artery occlusion. ...

journal_title：Neuroscience letters

authors： Henrich-Noack P,Baldauf K,Reiser G,Reymann KG

更新日期：2008-02-20 00:00:00

abstract：:Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show th...

journal_title：Neuroscience letters

authors： Endres HC,da Rosa JG,Kabasele Kalala C,Barcellos HH,Bertol CD,Gil Barcellos LJ,Rossato-Grando LG

更新日期：2017-05-22 00:00:00

abstract：:The projections of neurons, in and around the A1 noradrenergic cell group of the caudal ventrolateral medulla (VLM), to nucleus of the solitary tract (NTS) were studied in the cat using the anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L). PHA-L was micro-iontophoresed into the region of the A1 nora...

journal_title：Neuroscience letters

authors： Roder S,Ciriello J

更新日期：1992-01-06 00:00:00

abstract：:A new method for on-line analysis of in vivo differential normal pulse voltammograms is reported. They are fitted by least squares to an expression describing the contribution of different electroactive species and the baseline. Its validity for resolving ascorbate (AA), dopamine (DA) and DOPAC signals is evidenced by...

journal_title：Neuroscience letters

authors： Gonzalez-Mora JL,Sanchez-Bruno JA,Mas M

更新日期：1988-03-21 00:00:00

abstract：:Traumatic spinal cord injury (SCI) is a devastating condition of CNS which leads to loss of sensory as well as motor functions. Secondary damage after SCI initiates cascade of events that creates an inhibitory milieu for axonal growth and repair. Combinatorial therapies are the hope to attenuate secondary injury progr...

journal_title：Neuroscience letters

authors： Bhattacharyya S,Dinda A,Vishnubhatla S,Anwar MF,Jain S

更新日期：2021-01-10 00:00:00

abstract：:Estrogen levels in rats are positively correlated with enhanced memory function and hippocampal dendritic spine density. There is much less work on the long-term effects of estradiol manipulation in preadolescent rats. The present work examined how injections of estradiol during postnatal days 19-22 (p19-22; preadoles...

journal_title：Neuroscience letters

authors： Wartman BC,Keeley RJ,Holahan MR

更新日期：2012-10-24 00:00:00

abstract：:In schizophrenic psychoses, structural and functional alterations of the amygdala have been demonstrated by several neuroimaging studies. However, postmortem examinations on the brains of schizophrenics did not confirm the volume changes reported by volumetric magnetic resonance imaging (MRI) studies. In order to addr...

journal_title：Neuroscience letters

authors： Kalus P,Slotboom J,Gallinat J,Wiest R,Ozdoba C,Federspiel A,Strik WK,Buri C,Schroth G,Kiefer C

更新日期：2005-03-03 00:00:00

abstract：:Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and mig...

journal_title：Neuroscience letters

authors： Hung CF,Lung FW,Chen CH,O'Nions E,Hung TH,Chong MY,Wu CK,Wen JK,Lin PY

更新日期：2011-10-31 00:00:00

abstract：:The unensheathed axons in the spinal roots of adult dystrophic mice were examined by freeze-fracture electron microscopy. In most areas of these abnormal fibers the distribution of intramembraneous particles was similar to that of the internodal segments of normal axons with many more particles on the PF (internal) le...

journal_title：Neuroscience letters

authors： Bray GM,Cullen MJ,Aguayo AJ,Rasminsky M

更新日期：1979-07-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear...

journal_title：Neuroscience letters

authors： Hostenbach S,Cambron M,D'haeseleer M,Kooijman R,De Keyser J

更新日期：2014-04-17 00:00:00

abstract：:This report concerns an ultrastructural study of the synapses present on the surface of somata of normal-looking Betz cells in the fifth layer of motor cortex of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 age-matched, neurologically normal control individuals were included for compariso...

journal_title：Neuroscience letters

authors： Sasaki S,Iwata M

更新日期：1999-06-11 00:00:00

abstract：:In newborns, hypoxia elicits defensive behaviors including awakening from sleep, body movements and crying. An inability to produce this defense response is a risk factor for sudden infant death syndrome and other respiratory control disorders. In this study, we examined the possibility that the defense response to hy...

journal_title：Neuroscience letters

authors： Bollen B,Bouslama M,Matrot B,D'Hooge R,Van den Bergh O,Gallego J

更新日期：2007-06-15 00:00:00

abstract：:Genetic polymorphism has been reported in the 3'-untranslated region (3'-UTR) of the human dopamine transporter (DAT) gene and the variable number of tandem repeat (VNTR) polymorphism has been proposed to be associated with normal personal traits or psychoneurological disorders. To assess the variation of this region ...

journal_title：Neuroscience letters

authors： Inoue-Murayama M,Adachi S,Mishima N,Mitani H,Takenaka O,Terao K,Hayasaka I,Ito S,Murayama Y

更新日期：2002-12-16 00:00:00

abstract：:Epileptiform activity is a state often induced in vitro in order to study seizures and antiepileptic/anticonvulsant drugs. Traditional methods of evaluating drug effects have commonly relied upon measuring changes in the frequency and duration of such events. We have used a recently developed mathematical technique ba...

journal_title：Neuroscience letters

authors： Harrison PK,Tattersall JE,Clement RA

更新日期：2004-03-11 00:00:00

abstract：:The somatosensory homunculus has been identified during stimulation of median (at wrist and elbow), femoral, tibial and pudendal nerves of the left hemibody via the neuromagnetic imaging technique. The somatic representations of different body districts have been localized in the somatosensory cortex, by means of an e...

journal_title：Neuroscience letters

authors： Narici L,Modena I,Opsomer RJ,Pizzella V,Romani GL,Torrioli G,Traversa R,Rossini PM

更新日期：1991-01-02 00:00:00

abstract：:The effects of severe hypoglycemia on perforant path-evoked field potentials were examined in the rat hippocampus. Although a complete loss of this response was noted when blood glucose concentration fell below 1 mM, this occurred before cessation of electroencephalogram (EEG) activity. Both spontaneous and evoked res...

journal_title：Neuroscience letters

authors： Butcher SP,Jacobson I,Sandberg M,Hagberg H,Hamberger A

更新日期：1987-05-19 00:00:00

abstract：:A two-stage model of sustained neural activity in the prefrontal cortex is proposed in order to simulate feature binding and capacity limits in visual working memory. In the first stage, object features are stored in parallel network layers without explicit conjunctions. A second stage binds features into integrated o...

journal_title：Neuroscience letters

authors： Domijan D

更新日期：2003-10-23 00:00:00

abstract：:The origin of sympathetic and sensory innervation of the elbow and knee joint was studied by the intra-axonal transport method. After injection of WGA-HRP into the elbow and knee joint unilaterally in adult monkeys (macaca fascicularis), labelled cells were observed ipsilaterally in both the sympathetic and dorsal roo...

journal_title：Neuroscience letters

authors： Wiberg M,Widenfalk B

更新日期：1991-06-24 00:00:00

abstract：:The human basal forebrain has been known to contain many neurons immunoreactive (ir) to tyrosine hydroxylase (TH; the first dopamine-synthesizing enzyme). We examined whether these neurons might contain aromatic L-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) by dual labeling immunohist...

journal_title：Neuroscience letters

authors： Ikemoto K,Nagatsu I,Kitahama K,Jouvet A,Nishimura A,Nishi K,Maeda T,Arai R

更新日期：1998-02-27 00:00:00

abstract：:The slow Wallerian degeneration protein (WldS), a fusion protein containing amino-terminal E4B and full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by physical damages, toxins and genetic mutations which result in patients being diagnosed with neurodegenerative di...

journal_title：Neuroscience letters

authors： Watanabe M,Tsukiyama T,Hatakeyama S

更新日期：2007-01-16 00:00:00

abstract：:A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

journal_title：Neuroscience letters

authors： Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

更新日期：2013-10-25 00:00:00