Acute inflammation differentially alters the activity of two classes of rat spinal visceral nociceptive neurons.

Abstract:

:Quantitative neurophysiological studies have identified the presence of at least two spinal neuron populations (ABRUPT and SUSTAINED) which are excited by the noxious visceral stimulus colorectal distension (CRD). The present study examined the effects of acute colorectal inflammation on the activity of dorsal horn neurons in decerebrate, cervical spinal cord-transected male rats. Extracellular recordings were made using tungsten microelectrodes and inflammation was produced by intracolonic instillation of turpentine (25% solution). The total activity of SUSTAINED neurons during CRD increased starting one hour after turpentine instillation whereas the total activity of ABRUPT neurons during CRD, as a group, was unaffected during the two hours of study. Increases in total activity during CRD correlated with increases in spontaneous activity. These observations further support that visceral nociception travels by a dual pathway and suggest a predominant role for SUSTAINED neurons in the signaling of visceral pain-related events.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ness TJ,Gebhart GF

doi

10.1016/s0304-3940(00)00832-6

keywords:

subject

Has Abstract

pub_date

2000-03-10 00:00:00

pages

131-4

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

S0304394000008326

journal_volume

281

pub_type

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