Abstract:
:Kainic acid administration induces status epilepticus seizures in the rat which damage CA1 and CA3 hippocampal neurons. Rats made hypoglycemic prior to seizure had enhanced volumes of damage, when compared to normo- or hyperglycemic rats. The mild hypoglycemia was not in the range which, itself, typically produces hippocampal damage. This suggests that limited energy availability compromised the ability of neurons to survive seizures. Our data also suggest that the CA1 damage seen after status epilepticus is not hypoxic-ischemic in origin, since elevating pre-seizure glucose concentrations to a range which typically exacerbates hypoxic-ischemic CA1 damage did not augment status-epilepticus CA1 damage.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sapolsky RM,Stein BAdoi
10.1016/0304-3940(89)90156-0subject
Has Abstractpub_date
1989-02-13 00:00:00pages
157-62issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(89)90156-0journal_volume
97pub_type
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