Effect of cytosine arabinoside on rat cerebral explants: fibroblasts and reactive microglial cells as the primary cellular barrier to neurite growth.

abstract：:Nerve guide implants approved for human application in the peripheral nervous system generally fail to bridge lesion gaps longer than 2 cm and cannot match the clinical performance of autologous nerve transplants. Since current synthetic implants are simply hollow tubes, we aim to recreate the native microarchitecture...

journal_title：Neuroscience letters

authors： Nichterwitz S,Hoffmann N,Hajosch R,Oberhoffner S,Schlosshauer B

更新日期：2010-10-29 00:00:00

abstract：:The effect of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), on the ethanol-evoked release of brain ascorbate (AA) was investigated in freely moving rats using an in vivo voltammetry technique. Ethanol (1.0 g/kg, intraperitoneal injection, i.p.) increase...

journal_title：Neuroscience letters

authors： Wu C

更新日期：1993-07-09 00:00:00

abstract：:The endosome/lysosome system in the nervous system is critically important for a variety of neuronal functions such as neurite outgrowth, retrograde transport, and synaptic plasticity. In neurons, the endosome/lysosome system is crucial for the activity-dependent internalization of membrane proteins and contributes to...

journal_title：Neuroscience letters

authors： Tsuruta F,Dolmetsch RE

更新日期：2015-09-25 00:00:00

abstract：:Using immunohistochemistry with specific antisera against dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, we present the first description of the adrenergic structures of the sheep medulla oblongata. Dopamine-beta-hydroxylase-immunoreactive perikarya in the sheep brain are localized as described ...

journal_title：Neuroscience letters

authors： Tillet Y

更新日期：1988-12-19 00:00:00

abstract：:We established the procedures for cryopreservation and primary culture of fetal cerebral neurons of cynomolgus monkeys (Macaca fascicularis). Three developmental stages of fetuses (80, 93, and 102 days of gestation) were compared to determine the optimal stage of cerebrum development for primary culture. Among the thr...

journal_title：Neuroscience letters

authors： Negishi T,Ishii Y,Kawamura S,Kuroda Y,Yoshikawa Y

更新日期：2002-08-02 00:00:00

abstract：:Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

journal_title：Neuroscience letters

authors： Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

更新日期：2010-03-26 00:00:00

abstract：:The orexinergic neurons, localized in the perifornical hypothalamic area (PeF), are active during waking and quiet during non-rapid eye movement (non-REM) and REM sleep. Orexins promote arousal and suppress non-REM and REM sleep. Although in vitro studies suggest that PeF-orexinergic neurons are under glutamatergic in...

journal_title：Neuroscience letters

authors： Alam MA,Mallick BN

更新日期：2008-07-18 00:00:00

abstract：:On the basis of our previous observations which indicated that transforming growth factor beta1 (TGFbeta1) affects the gene expression and the release of luteinizing hormone-releasing hormone (LHRH) in GT1-1 cells, we have presently evaluated whether also TGFbeta2 might be effective on these parameters. The data here ...

journal_title：Neuroscience letters

authors： Messi E,Galbiati M,Magnaghi V,Zucchi I,Martini L,Melcangi RC

更新日期：1999-08-06 00:00:00

abstract：:The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and le...

journal_title：Neuroscience letters

authors： Larson J,Jessen RE,Uz T,Arslan AD,Kurtuncu M,Imbesi M,Manev H

更新日期：2006-01-23 00:00:00

abstract：:In order to test the hypothesis that ethanol (EtOH)-induced changes in growth factor signal transduction contribute to the teratogenic effects of EtOH in the developing brain, neonatal rat pups were administered a single dose of EtOH during the brain growth spurt (5 days of age, PN5). Hippocampal mitogen-activated/ext...

journal_title：Neuroscience letters

authors： Davis MI,Szarowski D,Turner JN,Morrisett RA,Shain W

更新日期：1999-09-10 00:00:00

abstract：:The association between insulin degrading enzyme (IDE) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial. To assess the association between IDE polymorphisms and AD risk, a meta-analysis was performed. We systematically reviewed relevant studies retr...

journal_title：Neuroscience letters

authors： Zhang Y,Wang B,Wan H,Zhou Q,Li T

更新日期：2013-04-29 00:00:00

abstract：:Mere observation of objects in our surroundings can potentiate movement, a fact reflected by visually-primed activation of motor cortical networks. This mechanism holds potential value for reactive balance control where recovery actions of the arms or legs must be targeted to a new support base to avoid a fall. The pr...

journal_title：Neuroscience letters

authors： McDannald DW,Mansour M,Rydalch G,Bolton DAE

更新日期：2018-09-14 00:00:00

abstract：:In fetal and adult human brains, calbindin immunoreactivity (CB-ir) of neostriatal neuropil showed inhomogeneous pattern. A mosaic of CB-ir neuropil patches matching the acetylcholinesterase (AChE)-reactive patches and most of the encapsulated cell-dense islands was distributed in a lighter stained background matrix. ...

journal_title：Neuroscience letters

authors： Letinić K,Kostović I

更新日期：1996-12-20 00:00:00

abstract：:Sleep fragmentation due to intermittent nocturnal arousal resulting in a reduction of total sleep time and sleep efficiency is a common symptom among people with Alzheimer's disease (AD) and elderly people with normal cognitive function. Although epidemiological studies have indicated an association between sleep frag...

journal_title：Neuroscience letters

authors： Minakawa EN,Miyazaki K,Maruo K,Yagihara H,Fujita H,Wada K,Nagai Y

更新日期：2017-07-13 00:00:00

abstract：:At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes....

journal_title：Neuroscience letters

authors： Ravizza T,Velísková J,Moshé SL

更新日期：2003-02-20 00:00:00

abstract：:In the presence of atropine electrical transmural stimulation (using repetitive volleys, e.g. 3 pulses at 50 Hz applied every 4 s) of full thickness longitudinal strips of guinea-pig ileum produced non-cholinergic excitatory junction potentials (EJPs) and inhibitory junction potentials (IJPs) in the circular muscle la...

journal_title：Neuroscience letters

authors： Taylor GS,Bywater RA

更新日期：1986-01-02 00:00:00

abstract：:A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cyt...

journal_title：Neuroscience letters

authors： Rosenmann H,Meiner Z,Dresner-Pollak R,Kahana E,Aladjem Z,Grenader T,Wertman E,Abramsky O

更新日期：2004-06-10 00:00:00

abstract：:This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

journal_title：Neuroscience letters

authors： Motl RW,Knowles BD,Dishman RK

更新日期：2003-08-21 00:00:00

abstract：:The mouse model of transcranial permanent occlusion of the middle cerebral artery (tpMCAO) is widely used in stroke research. Here we quantified infarct size using a conventional histological method at several post-ischaemic times, going beyond the commonly analysed period of up to 2 days, following artery occlusion. ...

journal_title：Neuroscience letters

authors： Henrich-Noack P,Baldauf K,Reiser G,Reymann KG

更新日期：2008-02-20 00:00:00

abstract：:Previous studies from our team have shown that a 12 month ethanol administration induced deficits in a sequential alternation task, whereas a 6 month treatment had no effects. We have already shown that the 12 month treatment induced deficits both in diencephalic and hippocampal structures, whereas the 6 month treatme...

journal_title：Neuroscience letters

authors： Beracochea D,Jaffard R

更新日期：1991-12-16 00:00:00

abstract：:Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and exam...

journal_title：Neuroscience letters

authors： Rogério F,Teixeira SA,de Souza Queiroz L,De Nucci G,Langone F

更新日期：2001-07-13 00:00:00

abstract：:The effect of prenatal ethanol exposure on the number of parvalbumin-immunoreactive (PA+) GABAergic neurons in the adult rat anterior cingulate cortex was determined. Pregnant Long-Evans rats were maintained on one of three diets throughout gestation: an ethanol-containing liquid diet, a similar, control liquid diet w...

journal_title：Neuroscience letters

authors： Moore DB,Quintero MA,Ruygrok AC,Walker DW,Heaton MB

更新日期：1998-06-12 00:00:00

abstract：:Two types of mRNAs for neurofibromin isoforms, which are produced by Von Recklinghausen neurofibromatosis (NF1) gene, have so far been identified. In the present study, we analyzed the differential expression of the two NF1 mRNAs in 16 cases of human astrocytic tumors and in surrounding normal tissues by the RNA-polym...

journal_title：Neuroscience letters

authors： Tokuyama T,Uemura K,Fujita M

更新日期：1995-08-25 00:00:00

abstract：:During early postnatal phase, the environment deeply affects developmental trajectories through epigenetic mechanisms that control the levels of key molecules for brain function, such as neurotrophins. Indeed, it has been shown that adverse early experiences induce epigenetic modifications leading to decreased brain d...

journal_title：Neuroscience letters

authors： Branchi I,Karpova NN,D'Andrea I,Castrén E,Alleva E

更新日期：2011-05-20 00:00:00

abstract：:In vivo electrochemistry was used to determine the effects of locally applied raclopride (a D2 receptor antagonist) and SCH-23390 (a D1 receptor antagonist) on the clearance of locally applied dopamine in the striatum, nucleus accumbens, and medial prefrontal cortex of rats. Chronoamperometric recordings were continuo...

journal_title：Neuroscience letters

authors： Cass WA,Gerhardt GA

更新日期：1994-08-01 00:00:00

abstract：:Tyrosine phosphorylation is an important means for regulating post-ischemic signal transduction. In this article, brain ischemia was induced by four-vessel occlusion, and the effect of ischemia/reperfusion on proline-rich tyrosine kinase 2 (Pyk2) was studied. Tyrosine phosphorylation of Pyk2 in Sprague-Dawley rat hipp...

journal_title：Neuroscience letters

authors： Liu Y,Zhang GY,Hou XY,Xu TL

更新日期：2003-09-18 00:00:00

abstract：:Aging is associated with cognitive deterioration. A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly po...

journal_title：Neuroscience letters

authors： Yeh HL,Hou SJ,Yen FC,Hong CJ,Liou YJ,Yang AC,Liu ME,Tsai SJ

更新日期：2011-10-17 00:00:00

abstract：:Transcranial magnetic stimulation is a non-invasive tool in clinical diagnostics and therapy for physiological and psychological diseases and has an increased application in experimental neurophysiology. Despite this, the mechanisms of magnetic stimulation of the central nervous system remain still unclear. We applied...

journal_title：Neuroscience letters

authors： Stock M,Kirchner B,Waibler D,Cowley DE,Pfaffl MW,Kuehn R

更新日期：2012-09-27 00:00:00

abstract：:Iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate (ATP) and adenosine 5'-monophosphate (AMP) have been tested on rat cerebral cortical neurons. 2-Azido-AMP and 2-azido-ATP had a powerful depressant action on the spontaneous firing of cortical neurons. Both compounds were equipotent...

journal_title：Neuroscience letters

authors： Phillis JW

更新日期：1981-01-01 00:00:00

abstract：:We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expect...

journal_title：Neuroscience letters

authors： Adén U,Bona E,Hagberg H,Fredholm BB

更新日期：1994-10-24 00:00:00