Abstract：
:The association between insulin degrading enzyme (IDE) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial. To assess the association between IDE polymorphisms and AD risk, a meta-analysis was performed. We systematically reviewed relevant studies retrieved by PubMed, Embase, AlzGene, CNKI and Web of Science. Finally, 8 articles were identified for rs3758505 polymorphism and 5 for rs1832196 polymorphism. The pooled ORs were performed for all the four genetic models. Subgroup analysis was also performed by ethnicity. Results suggested that rs3758505 polymorphism was unlikely to be associated with genetic susceptibility of AD based on the current published studies. However, for the rs1832196 polymorphism, significant association with AD was found by the dominant model in overall and subgroup analysis. However, larger scale association studies are necessary to further validate the association of IDE polymorphisms with sporadic AD risk and to define potential gene-gene interactions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhang Y,Wang B,Wan H,Zhou Q,Li Tdoi
10.1016/j.neulet.2013.01.051subject
Has Abstractpub_date
2013-04-29 00:00:00pages
132-7eissn
0304-3940issn
1872-7972pii
S0304-3940(13)00108-0journal_volume
541pub_type
杂志文章,meta分析abstract：:There is a growing body of evidence that the ventromedial prefrontal cortex (VMPFC) is implicated in the new learning of visual items. Little is known, however, as to the involvement of that portion of the prefrontal cortex in the learning of temporal and spatial relationship of those items. The aim of the present stu...
journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
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abstract：:Hearing loss is a common sensory disorder that affects more than 360 million people worldwide, and is primarily caused by the loss of hair cells (HCs). Ototoxic drugs, viral infections, genetic predisposition, aging or noise all damage HCs. 3β-hydroxysteroid-Δ24 reductase (DHCR24), one enzyme in the cholesterol biosyn...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.10.053
更新日期：2005-02-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(93)90323-d
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.11.007
更新日期：2004-03-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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