Bird viruses in multiple sclerosis: combination of viruses or Marek's alone?

abstract：:Cerebellar granule neurons can be maintained in culture in a medium containing high serum and depolarising levels of KCl. When serum is removed and the KCl levels lowered from 25 to 5 mM, the cells undergo apoptosis. Apoptosis can be prevented by inhibitors of transcription or translation, suggesting a need for macrom...

journal_title：Neuroscience letters

authors： Ginham R,Harrison DC,Facci L,Skaper S,Philpott KL

更新日期：2001-04-20 00:00:00

abstract：:The excitotoxic cell death and the release of gamma-amino-butyric acid (GABA) evoked by excitatory amino acids (EAAs) were comparatively examined in rat cortical sister cultures grown in serum-free (N2) and serum-supplemented (SSM) media. Cell death was induced by 24 h exposure to 1 mM N-methyl-D-aspartate (NMDA), alp...

journal_title：Neuroscience letters

authors： Erdö SL,Cai N,Lakics V

更新日期：1993-04-02 00:00:00

abstract：:Tonsils have a privileged situation in the immune system in that they are in touch with the environment. Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system. We have studied a group of thirty five children with recurrent acute tonsil...

journal_title：Neuroscience letters

authors： Lopez-Gonzalez MA,Guerrero JM,Sanchez B,Delgado F

更新日期：1998-05-15 00:00:00

abstract：:A differential localization of binding sites in the rat brain for [3H]D-Ala2,Leu5-enkephalin ([3H]DADL) and [3H]etorphine ([3H]Eto) was been demonstrated by an in vitro autoradiography technique. Labeling with [3H]DADL was found predominantly in septum and paraventricular nuclei of hypothalamus, whereas [3H]Eto labeli...

journal_title：Neuroscience letters

authors： Duka T,Schubert P,Wüster M,Stoiber R,Herz A

更新日期：1981-01-20 00:00:00

abstract：:The roles played by glycine- and glutamate-mediated synaptic transmission in the generation of 5-hydroxytryptamine (5-HT)-induced rhythmic activity were examined in isolated spinal cord preparations from fetal rats. Bath application of 5-HT (0.1-30 microM) evoked rhythmic activity in lumbar ventral roots at and after ...

journal_title：Neuroscience letters

authors： Nakayama K,Nishimaru H,Kudo N

更新日期：2001-07-06 00:00:00

abstract：:The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats. It was found that intracerebroventricular (i.c.v.) injection of 0.1 microg OFQ had no effect on formalin-in...

journal_title：Neuroscience letters

authors： Zhu CB,Cao XD,Xu SF,Wu GC

更新日期：1997-10-10 00:00:00

abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...

journal_title：Neuroscience letters

authors： Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JM

更新日期：2003-10-02 00:00:00

abstract：:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to...

journal_title：Neuroscience letters

authors： Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JA

更新日期：2004-04-01 00:00:00

abstract：:High- and low-voltage activated calcium channel currents (HVA and LVA) were inhibited by acetylcholine (10-100 microM) and baclofen (10 microM) in adult rat sensory neurons. This modulatory effect was present on dihydropyridine (nifedipine 1 microM) and/or omega-conotoxin (3.2 microM, 2-5 h incubation) insensitive com...

journal_title：Neuroscience letters

authors： Formenti A,Sansone V

更新日期：1991-10-14 00:00:00

abstract：:Parkinson's disease (PD) is a progressive age-related debilitating motor disorder and the second most common neurodegenerative disease after Alzheimer's disease. In this study, we aimed to investigate the expression of 24 candidate miRNAs in PD and to assess their diagnostic value in patients with PD. We collected ser...

journal_title：Neuroscience letters

authors： Cao XY,Lu JM,Zhao ZQ,Li MC,Lu T,An XS,Xue LJ

更新日期：2017-03-22 00:00:00

abstract：:We have studied nicotinic acetylcholine receptors in spontaneously hypertensive 'stroke prone' (SHsp) rats. We found a significant decrease in 125I-alpha-bungarotoxin binding and alpha7 subunit mRNA levels in cortical areas of the SHsp rats with respect to Wistar Kyoto (WKy) normotensive rats. Antihypertensive drug tr...

journal_title：Neuroscience letters

authors： Ferrari R,Frasoldati A,Leo G,Torri C,Zini I,Agnati LF,Zoli M

更新日期：1999-12-31 00:00:00

abstract：:In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (...

journal_title：Neuroscience letters

authors： le Blanc LM,van Lieshout AW,Adema GJ,van Riel PL,Verbeek MM,Radstake TR

更新日期：2006-04-10 00:00:00

abstract：:Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults. Its similarity to other psychostimulants suggests that, at certain doses, the drug may generate lasting neuroadaptations that can be detrim...

journal_title：Neuroscience letters

authors： Taukulis HK,Bigney EE,Fry MD,Hooper C

更新日期：2014-04-30 00:00:00

abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

journal_title：Neuroscience letters

authors： Choi DJ,Kwon JK,Joe EH

更新日期：2018-10-15 00:00:00

abstract：:Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear...

journal_title：Neuroscience letters

authors： Hostenbach S,Cambron M,D'haeseleer M,Kooijman R,De Keyser J

更新日期：2014-04-17 00:00:00

abstract：:In the present experiment, under drinking of 0.01% methamphetamine (MA), young rats exhibited free-running locomotor rhythm ranging from 24.6 to 30.9 h period under light-dark cycle. In contrast, 24-month-old rats showed a low activity and did not exhibit MA-induced free-running rhythm. When MA was injected at a fixed...

journal_title：Neuroscience letters

authors： Shibata S,Minamoto Y,Ono M,Watanabe S

更新日期：1994-05-19 00:00:00

abstract：:Vesicular monoamine transporter 2 (VMAT2) is responsible for packing dopamine into vesicles, and reduces the effects of neurotoxins by sequestering them into vesicles. In this report, we tested the hypothesis that VMAT2 is associated with Lewy body (LB) formation by immunohistochemical staining of midbrain and cortica...

journal_title：Neuroscience letters

authors： Yamamoto S,Fukae J,Mori H,Mizuno Y,Hattori N

更新日期：2006-04-03 00:00:00

abstract：:The vertebrate retina is known to mediate both visual and non-image-forming photic responses. With the use of statistical analyses of sections immunohistochemically labelled with a polyclonal antiserum against the activated form of protein CREB (p-CREB), a transcription factor which participates in some neural respons...

journal_title：Neuroscience letters

authors： Alvarez-López C,Cernuda-Cernuda R,Paniagua MA,Alvarez-Viejo M,Fernández-López A,García-Fernández JM

更新日期：2004-03-11 00:00:00

abstract：:We investigated glutamate-induced neuron response in the ventral nerve cord of the earthworm (Eisenia foetida) using a voltage-sensitive dye-imaging technique. Isolated earthworm ganglia were stained by fluorescence voltage-sensitive dye, RH414, and voltage image was acquired by a conventional charge-coupled device (C...

journal_title：Neuroscience letters

authors： Oka K,Ogawa H,Fujita S

更新日期：1994-09-26 00:00:00

abstract：:We previously demonstrated the preventive effect of insulin-like growth factor 1 (IGF-1) on steroid myopathy in rats. However, the mechanism by which IGF-1 inhibits steroid myopathy remains unclear. Recent studies have revealed that glutamine synthetase (GS) is induced by glucocorticoid and may be related to the devel...

journal_title：Neuroscience letters

authors： Kimura K,Kanda F,Okuda S,Chihara K

更新日期：2001-04-20 00:00:00

abstract：:The action of gamma-aminobutyric acid A (GABAA) and B (GABAB)-agonists has been studied on the membrane potential of astrocytes in explant cultures of rat spinal cord by means of intracellular microelectrode recordings. The GABAB-agonists (-)-baclofen and CGP 27 492 (3-aminopropyl phosphonous acid; 10(-6) to 10(-4) M)...

journal_title：Neuroscience letters

authors： Hösli L,Hösli E,Redle S,Rojas J,Schramek H

更新日期：1990-09-18 00:00:00

abstract：:Recent findings indicated that the excitotoxicity of glutamate analogues was prevented in the mammalian nervous system by N-methyl-D-aspartate (NMDA) antagonists. The neurodegenerative effects of kainic acid, and the putative protection of MK-801 and 6,7-dinitroquinoxaline-2,3-dione (DNQX), were investigated by morpho...

journal_title：Neuroscience letters

authors： Villani L,Carraro S,Guarnieri T

更新日期：1995-06-09 00:00:00

abstract：:To establish a model for functional hyperemia in the rat visual cortex, cortical blood flow responses to flash stimulation were measured with the laser Doppler flow (LDF) technique at various levels of halothane anesthesia. The concentration-dependent effect of halothane on arterial pressure and its consequent effect ...

journal_title：Neuroscience letters

authors： Schulte ML,Hudetz AG

更新日期：2006-02-06 00:00:00

abstract：:The efficiency of antisense approaches to produce a selective regional inhibition of the expression of brain 5-HT1A receptors was tested in the rat. In vivo ICV injections of modified antisense oligodesoxynucleotides yielded at most an 18% specific decrease in 5-HT1A receptor expression in the hippocampus only, as mea...

journal_title：Neuroscience letters

authors： Sari Y,Sibella C,Vergé D,Hamon M,Miquel MC

更新日期：1999-01-15 00:00:00

abstract：:The expression of pre-pro-somatostatin (ppSOM) mRNA in the spinal cord of the developing rat was determined by in situ hybridization. Expression of ppSOM mRNA was detected in cells in the gray matter of the dorsal and ventral horns at day E15, the earliest stage examined in this study. Expression of ppSOM mRNA persist...

journal_title：Neuroscience letters

authors： Ho RH,Wu W,Elde R

更新日期：1993-12-12 00:00:00

abstract：:Methylated beta-carboline compounds are mammalian indole metabolites that we have proposed to be endogenous neurotoxins due to their structural similarity to MPP+, the active oxidized product of the dopaminergic toxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Several laboratories have demonstrated that MPP...

journal_title：Neuroscience letters

authors： Neafsey EJ,Drucker G,Raikoff K,Collins MA

更新日期：1989-11-06 00:00:00

abstract：:Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated w...

journal_title：Neuroscience letters

authors： Caruana DA,Reed SJ,Sliz DJ,Chapman CA

更新日期：2007-10-09 00:00:00

abstract：:N-omega-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in vivo within S2 recept...

journal_title：Neuroscience letters

authors： Moerlein SM,Perlmutter JS

更新日期：1991-02-11 00:00:00

abstract：:To elucidate whether high serum lipid peroxidation rates may increase the risk of developing Parkinson's disease (PD), we assessed serum levels of malondialdehyde (MDA), an intermediate in lipid peroxidation processes, in 37 PD patients, with their spouses as the control group. Serum MDA levels did not differ signific...

journal_title：Neuroscience letters

authors： Molina JA,Jiménez-Jiménez FJ,Fernandez-Calle P,Lalinde L,Tenias JM,Pondal M,Vazquez A,Codoceo R

更新日期：1992-03-02 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00