Abstract:
:Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear to be important molecular mediators of astrogliosis. Chronic focal lesions in multiple sclerosis are characterized by a very dense astrogliosis. Other mechanisms, such as astrocytic β2 adrenergic receptor deficiency, upregulation of endothelin-1 and tissue transglutaminase, may contribute to astroglial scarring in multiple sclerosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hostenbach S,Cambron M,D'haeseleer M,Kooijman R,De Keyser Jdoi
10.1016/j.neulet.2013.10.012subject
Has Abstractpub_date
2014-04-17 00:00:00pages
39-41eissn
0304-3940issn
1872-7972pii
S0304-3940(13)00916-6journal_volume
565pub_type
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