Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits.

Abstract:

:The febrile responses induced by i.v. administrations of staphylococcal enterotoxin A (SEA) was mimicked by direct injection of SEA into the organum vasculosum laminae terminalis (OVLT) in unanesthetized rabbits. Compared with the febrile responses induced by i.v. injection of SEA, the OVLT route of injection required a much lower dose of SEA to produce a similar fever. Furthermore, the fever induced by intra-OVLT or i.v. injection of SEA was significantly attenuated by pretreatment with intra-OVLT injection of anisomycin (a protein synthesis inhibitor), indomethacin or diclofenac (inhibitors of cyclo-oxygenase (COX)), and aminoguanidine or dexamethasone (inhibitors of inducible nitric oxide synthase (iNOS)). These results suggest that COX or iNOS pathway in the OVLT mediate the SEA-induced fever in rabbits.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Huang WT,Lin MT,Won SJ

doi

10.1016/s0304-3940(97)00759-3

subject

Has Abstract

pub_date

1997-10-24 00:00:00

pages

53-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(97)00759-3

journal_volume

236

pub_type

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