Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

Abstract:

:Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Poncelet M,Maruani J,Calassi R,Soubrié P

doi

10.1016/s0304-3940(03)00397-5

keywords:

subject

Has Abstract

pub_date

2003-06-12 00:00:00

pages

216-8

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394003003975

journal_volume

343

pub_type

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