Abstract:
:Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Poncelet M,Maruani J,Calassi R,Soubrié Pdoi
10.1016/s0304-3940(03)00397-5keywords:
subject
Has Abstractpub_date
2003-06-12 00:00:00pages
216-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394003003975journal_volume
343pub_type
杂志文章abstract::It has been demonstrated that thyroxine deiodinating activity is present in rat pineal gland, and its activity increases significantly during the night time. We have studied whether mRNA for type II iodothyronine deiodinase is expressed in rat pineal gland and whether the nocturnal rise of pineal T4 deiodinating activ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00298-x
更新日期:1997-05-09 00:00:00
abstract::Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Identifying PD cognitive impairment (PDCI) in the early stage will help slow or prevent PD dementia. Susceptibility loci for PDCI are inconsistent in different studies. The aim of this study is to determine susceptibility loci for PDCI in t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135034
更新日期:2020-06-21 00:00:00
abstract::Glucose metabolism produces lactate and hydrogen ions in an anaerobic environment. Cerebral ischemia or hypoxia is believed to become progressively lactacidemic. Monocarboxylate transporters (MCTs) in endothelial cells are essential for the transport of lactate from the blood into the brain. In addition, it is conside...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135479
更新日期:2021-01-10 00:00:00
abstract::This study investigated differences in brain activation during meditation between meditators and non-meditators. Fifteen Vipassana meditators (mean practice: 7.9 years, 2h daily) and fifteen non-meditators, matched for sex, age, education, and handedness, participated in a block-design fMRI study that included mindful...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.04.074
更新日期:2007-06-21 00:00:00
abstract::Electroencephalogram (EEG) data is an effective indicator to evaluate driver fatigue. The 16 channels of EEG data are collected and transformed into three bands (θ, α, and β) in the current paper. First, 12 types of energy parameters are computed based on the EEG data. Then, Grey Relational Analysis (GRA) is introduce...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.11.014
更新日期:2012-01-11 00:00:00
abstract::Activation of central neuropeptide Y (NPY) receptors is known to produce several behavioral effects, including feeding, modulation of memory and antagonism of behavioral effects of stress. In addition, experiments in knock-out and transgenic mice have suggested a possible role of NPY regulation of voluntary ethanol in...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00904-7
更新日期:2002-10-25 00:00:00
abstract::This work explores the hypothesis that perturbations caused by ethanol on the regulatory role of retinoids in brain development may be a mechanism involved in the neuropathology of fetal alcohol syndrome. The interaction of ethanol and retinoic acid (RA) on RA receptor (RAR) beta and glial fibrillary acidic protein (G...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01538-x
更新日期:2000-11-17 00:00:00
abstract::Normal-learning children (NL) and children with learning disabilities (LD) reported their perceptions of unisensory (auditory or visual), concordant audiovisual (e.g. visual /apa/ and auditory /apa/) and conflicting (e.g. visual /aka/ and auditory /apa/) speech stimuli in quiet and noise (0 dB and -12 dB signal-to-noi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00971-6
更新日期:2003-11-06 00:00:00
abstract::The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These n...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90889-3
更新日期:1994-08-15 00:00:00
abstract::Radiofrequency lesions of the ventral mesencephalic tegmentum (VMT), a region located above the nucleus interpeduncularis, provoked a disappearance of the spontaneous alternation behavior. The lesioned rats scores (44%) are not different from the chance level, while the alternation rate amounts to 77% in the control g...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(76)90101-4
更新日期:1976-09-01 00:00:00
abstract::Supporting cell mitosis contributes significantly to hair cell regeneration in the acoustically damaged bird inner ear. Yet there may be another mechanism of hair cell replacement: supporting cell conversion. This study used cytosine arabinoside (Ara-C), an inhibitor of DNA synthesis, to better determine whether suppo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12367-3
更新日期:1996-02-16 00:00:00
abstract::The cellular location of kappa-opioid binding sites in the guinea pig cerebellum has been investigated. kappa-Opioid sites were labelled using [3H]ethylketocyclazocine in the presence of mu- and delta-blocking ligands. In vitro autoradiography demonstrated that this kappa-opioid binding was localized predominantly in ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90330-8
更新日期:1988-01-11 00:00:00
abstract::Immunoreaction for vasoactive intestinal polypeptide (VIP) in the ependymal cells was investigated using two different commercially available polyclonal antisera for VIP. Immunostaining with an anti-VIP serum showed strong reaction products in the ependymal cells of the central canal and the third ventricle, in additi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90171-7
更新日期:1989-12-04 00:00:00
abstract::Immunochemical characterization of glutamic acid decarboxylase (GAD) from brain extracts of newborn and adult rats was investigated using a GAD antiserum that was previously raised against brain GAD from adult rats. According to the immunoprecipitation and saturation curves, no significant differences could be found a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90703-9
更新日期:1989-05-22 00:00:00
abstract::Visual P300 responses were recorded by using checkerboard-type stimuli. (1) High amplitude P300-delta responses were visible even in single trial event-related potentials (ERPs). (2) The algorithm based on the 'delta response metric' provides an efficient selection criterion for evaluation of P300 single trials in ERP...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11912-g
更新日期:1995-09-15 00:00:00
abstract::Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded th...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90430-7
更新日期:1987-05-19 00:00:00
abstract::The neuromuscular junction (NMJ) is the vehicle for fast, reliable and robust communication between motor neuron and muscle. The unparalleled accessibility of this synapse to morphological, electrophysiological and genetic analysis has yielded an in depth understanding of many molecular components mediating its format...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2020.135014
更新日期:2020-07-13 00:00:00
abstract::The discrete distribution and pharmacological characteristics of melatonin binding sites in the bovine hippocampus were determined. Autoradiography revealed the presence of melatonin binding sites in the stratum lacunosum-molecularis of the hippocampus (CA1), stratum molecularis of the subiculum and in the enthorhinal...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11742-f
更新日期:1995-07-14 00:00:00
abstract::The pattern and distribution of the cortical projections from intermediate parts of the cholinergic basal magnocellular nucleus were studied by anterogradely transported Phaseolus vulgaris-leucoagglutinin. This immunocytochemical tracing technique reveals the detailed morphology and distribution of efferents from this...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90052-7
更新日期:1985-06-12 00:00:00
abstract::Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the...
journal_title:Neuroscience letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.neulet.2012.12.026
更新日期:2013-02-22 00:00:00
abstract:PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135250
更新日期:2020-09-25 00:00:00
abstract::We performed an experiment in which we challenged postural stability in 12 healthy subjects by providing artificial delayed visual feedback. A monitor at eye-height presented subjects with a visual representation of the location of their center-of-pressure (COP) and they were instructed to position their COP as accura...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.01.024
更新日期:2009-03-06 00:00:00
abstract::Hindlimb sensory deprivation is known to induce a decrease in the cortical representation of hindpaw, and an increase in the size of the cutaneous receptive fields. The aim of the present study was to determine (i) the time-course of recovery when the rat retrieves a normal use of its limbs after a 14-day period of se...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02050-x
更新日期:2001-08-24 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.01.052
更新日期:2016-03-11 00:00:00
abstract::The role of the dorsal hippocampus in the different stages of blocking was examined in a taste aversion learning task. Blocking is a learning effect in which one previously conditioned element of a compound makes the conditioning of the added element difficult. An effective blocking procedure with one trial in each st...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)11265-k
更新日期:1995-02-15 00:00:00
abstract::Antidromic action potentials were recorded from rat paraventricular nucleus (PVN) and supraoptic nucleus neurons following electrical stimulation of the pituitary stalk. Increases in stimulation frequency to 10 or 20 Hz caused progressive increases in antidromic latency and, often, failure of the antidromic potential ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90437-8
更新日期:1983-06-30 00:00:00
abstract::FasL has been shown to induce angiogenesis in vivo, however, the mechanism remains to be determined. We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL. Intercellular adhesion molec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.08.019
更新日期:2003-11-27 00:00:00
abstract::The Dex/CRH test is one of the most reliable neuroendocrine function tests for hypothalamic-pituitary-adrenocortical (HPA) system dysregulation in depression. Persistent overdrive of HPA system activity after successful antidepressant treatment predicts an enhanced risk for relapse of a depressive episode. As the reni...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00527-x
更新日期:2002-08-16 00:00:00
abstract::Monosynaptic evoked responses were used to localize dorsal root ganglion (DRG) afferent terminals within organotypic fetal mouse spinal cord explants which had been chronically exposed to purified bovine gangliosides during early development. Ganglioside grown cultures showed a highly significant increase in dorsal co...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90226-4
更新日期:1983-10-31 00:00:00
abstract::Somatostatin (SRIF) release from rat hypothalamus was investigated in vitro with a perifusion system. Glucagon (1 microM) and high potassium concentrations (56 mM) stimulated SRIF release in a calcium-dependent manner. Pretreatment of the rat with cysteamine (30 mg/100 g body weight, 7 h earlier) significantly reduced...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90445-7
更新日期:1983-06-30 00:00:00