GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release.

Abstract:

:Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pittaluga A,Raiteri M

doi

10.1016/0304-3940(87)90430-7

subject

Has Abstract

pub_date

1987-05-19 00:00:00

pages

363-7

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90430-7

journal_volume

76

pub_type

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