Abstract：
:The vanilloid receptor-1 (TRPV1), expressed by nociceptive fibers, is a transducer of thermal and chemical nociceptive messages. However, endogenous ligands excite TRPV1 receptors localized on central nociceptive terminals and interneurons. Using immunocytochemistry at the ultrastructural level, we show that TRPV1 is also expressed in spinal glial cells characterized as astrocyte by double labeling with glial fibrillary acid protein. Quantification of the labeling shows that the most numerous labeling is neuronal and that 7% of the total TRPV1 labeling is localized in astrocytes. The total absence of staining in TRPV1 knock out mice strongly suggests that true TRPV1 protein is present in astrocytes. The localization of TRPV1-containing astrocytes apposed to nociceptive C-terminals suggests that they may be involved in the control of pain transmission.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Doly S,Fischer J,Salio C,Conrath Mdoi
10.1016/j.neulet.2003.12.051keywords:
subject
Has Abstractpub_date
2004-03-04 00:00:00pages
123-6issue
2eissn
0304-3940issn
1872-7972pii
S0304394003014708journal_volume
357pub_type
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