Abstract:
:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1 (Transduction Labs) has been frequently used for the specific detection of alpha-synuclein. In this report, the epitope for Syn-1 is localized within residues 91-99 of human alpha-synuclein. Sequence differences exist in this domain that account for the specificity of Syn-1 for alpha- versus beta-synuclein. However, Syn-1 also displays reactivity with additional species (approximately 45 kDa) in brain homogenates from both wild-type and alpha-synuclein null mice, indicating a potential for cross-reactivity with a protein species that is unrelated to alpha-synuclein in brain tissue or extracts.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JMdoi
10.1016/s0304-3940(03)00781-xkeywords:
subject
Has Abstractpub_date
2003-10-02 00:00:00pages
133-5issue
2eissn
0304-3940issn
1872-7972pii
S030439400300781Xjournal_volume
349pub_type
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