Abstract:
:Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pringle AK,Niyadurupola N,Johns P,Anthony DC,Iannotti Fdoi
10.1016/s0304-3940(01)01795-5keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
29-32issue
1eissn
0304-3940issn
1872-7972pii
S0304394001017955journal_volume
305pub_type
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journal_title:Neuroscience letters
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更新日期:1993-06-11 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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