Heterogeneous dopamine receptor changes in early and late Huntington's disease.

abstract：:Gangliosides are major components of cell membranes and are particularly enriched in the mammalian brain where they represent the major lipid constituents of the neuronal cell surface. In the central nervous system, gangliosides have a close connection to many neurophysiological functions related to neurogenesis, prol...

journal_title：Neuroscience letters

authors： Jung WR,Kim HG,Kim KL

更新日期：2008-07-11 00:00:00

abstract：:The course of ageing leads to various changes in the nervous system, which can affect pain processing in the elderly. However, the affection of different components of the nociceptive system remains unclear. To investigate basic nocifensive responses, we compared age-related changes of autonomic and motor reflex respo...

journal_title：Neuroscience letters

authors： Mylius V,Kunz M,Hennighausen E,Lautenbacher S,Schepelmann K

更新日期：2008-12-03 00:00:00

abstract：:The content of two neuropeptides, somatostatin (SRIF) and neuropeptide Y (NPY) has been determined in two cerebral cortical areas of Alzheimer's disease brain and in age-matched control brains. The content of SRIF-like immunoreactivity (SRIF-LI) was found to be decreased in Alzheimer temporal cortex (Brodmann area 21)...

journal_title：Neuroscience letters

authors： Dawbarn D,Rossor MN,Mountjoy CQ,Roth M,Emson PC

更新日期：1986-09-25 00:00:00

abstract：:NMDA receptors play important roles in brain formation by taking part in synaptogenesis and apoptosis. In the present study, the expression of NMDA receptors was analyzed in a neural stem cell line, MSP-1, which lacks p53. p53 is a transcription factor involved in excitotoxic neuronal apoptosis. It is quite likely tha...

journal_title：Neuroscience letters

authors： Yamada K,Hisatsune T,Uchino S,Nakamura T,Kudo Y,Kaminogawa S

更新日期：1999-04-02 00:00:00

abstract：:Changes in contingent negative variation (CNV), a brain-evoked potential related in arousal, as well as in serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol and growth hormone (GH) levels were recorded in 12 male volunteers receiving either thyrotropin-releasing ...

journal_title：Neuroscience letters

authors： Strollo F,Amabile G,Fattapposta F,Strollo G,More M,Riondino G

更新日期：1988-11-11 00:00:00

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the pretectal areas were made, we searched for the route of light information from the eyes to the circadian pacemaker, which is considered to be located in the preoptic nucleus. The entrainment of circadian activit...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H,Takeuchi H

更新日期：1995-06-16 00:00:00

abstract：:Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highe...

journal_title：Neuroscience letters

authors： Ortega GJ,Sola RG,Pastor J

更新日期：2008-12-12 00:00:00

abstract：:The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

journal_title：Neuroscience letters

authors： Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

更新日期：2012-06-14 00:00:00

abstract：:c-Fos is one of the transcription factors contributing to the regulation of the downstream gene expression. Administration of dopamine D1 receptor agonist or D2 receptor antagonist have been known to induce c-Fos expressions in striatal projection neurons. We examined the effects of unilateral ablation of the globus p...

journal_title：Neuroscience letters

authors： Miwa H,Fuwa T,Nishi K,Mizuno Y

更新日期：1998-01-16 00:00:00

abstract：:The nuclear factor kappa B inducing kinase gene (NIK) is located near the region of the haplotype associated with progressive supranuclear palsy (PSP) in chromosome 17q. We have analysed the coding region of the NIK gene in PSP patients through single strand conformation polymorphism and direct sequencing, in order to...

journal_title：Neuroscience letters

authors： Campdelacreu J,Ezquerra M,Muñoz E,Oliva R,Tolosa E

更新日期：2003-04-10 00:00:00

abstract：:An antiserum to choline acetyltransferase, partially purified from bovine brain (anti-ChAT 1), when incubated with synaptosomes prepared from rat cerebral cortex in the presence of complement caused release of 10% of lactate dehydrogenase and 27% of ChAT. Sodium-dependent uptake of choline was totally abolished. Simil...

journal_title：Neuroscience letters

authors： Docherty M,Bradford HF

更新日期：1986-10-08 00:00:00

abstract：:Ribonuclease protection assays were performed on the basal hypothalamus (BH), the preoptic area (POA) and the thalamus (THAL) from female guinea pigs that were ovariectomized and implanted with morphine (n = 8) or placebo (n = 8) pellets for 1 week. An antisense [32P]rUTP labeled riboprobe, representing a 280 bp fragm...

journal_title：Neuroscience letters

authors： Rønnekleiv OK,Bosch MA,Cunningham MJ,Wagner EJ,Grandy DK,Kelly MJ

更新日期：1996-09-27 00:00:00

abstract：:The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), formed by interactions of tight junctions (TJs) in the endothelia or the choroids plexus, respectively, are important diffusion barriers between systemic circulation and neural tissue of the central nervous system (CNS). Epidemiological incid...

journal_title：Neuroscience letters

authors： Kang HS,Ahn HS,Kang HJ,Gye MC

更新日期：2006-07-10 00:00:00

abstract：:Tyrosine-hydroxylase immunoreactivity is demonstrable by the indirect immunofluorescence technique in a small sub-population of retinal neurones cultured from 2-day-old rabbits. Staining was only weak, restricted to a few neurones, and could not be observed in cultures of less than 10 days. Autoradiographical analysis...

journal_title：Neuroscience letters

authors： Osborne NN,Beaton DW,Vigny A,Neuhoff V

更新日期：1984-09-07 00:00:00

abstract：:Cultured embryonic mouse olfactory bulb cells formed asymmetric, symmetric, axodendritic, and dendrodendritic synapses. These neurons contained electron lucent, dense core, and coated vesicles. Dense core and coated vesicles had an average diameter of 71 and 80 nm, respectively. Two statistically different populations...

journal_title：Neuroscience letters

authors： Fracek SP Jr,Guo L,Schafer R

更新日期：1994-04-11 00:00:00

abstract：:Extracellular concentration of nitrite (NO2-), an oxidized product of nitric oxide (NO), was measured consecutively in the dorsal region of the rat suprachiasmatic nucleus (SCN) by means of in vivo microdialysis. The NO2- concentrations in the dialysates showed robust circadian rhythm under a 12:12 h light/dark cycle ...

journal_title：Neuroscience letters

authors： Mitome M,Shirakawa T,Oshima S,Nakamura W,Oguchi H

更新日期：2001-05-11 00:00:00

abstract：:Unusual reactions to auditory stimuli are often observed in autism and may relate to ineffective inhibitory modulation of sensory input (sensory gating). A previous study of P50 sensory gating did not reveal abnormalities in high-functioning school age children [C. Kemner, B. Oranje, M.N. Verbaten, H. van Engeland, No...

journal_title：Neuroscience letters

authors： Orekhova EV,Stroganova TA,Prokofyev AO,Nygren G,Gillberg C,Elam M

更新日期：2008-03-28 00:00:00

abstract：:Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modif...

journal_title：Neuroscience letters

authors： Lohman AW,Weilinger NL,Santos SM,Bialecki J,Werner AC,Anderson CL,Thompson RJ

更新日期：2019-03-16 00:00:00

abstract：:The ergoline derivatives, nicergoline (NIC) or dihydroergocristine (DHE) were administered at various doses (0.1, 0.5 and 1 mg/kg) to aged male rats subjected to labyrinth unilateral lesion (LBX). The nystagmus rate appeared to be lower in animals treated with DHE or NIC 1mg/kg than in saline-injected rats, when obser...

journal_title：Neuroscience letters

authors： Rampello L,Drago F

更新日期：1999-05-28 00:00:00

abstract：:A fundamental question in human sexuality regards the neural substrate underlying sexually-arousing representations. Lesion and neuroimaging studies suggest that dorsolateral pre-frontal cortex (DLPFC) plays an important role in regulating the processing of visual sexual stimulation. The aim of this Functional Near-In...

journal_title：Neuroscience letters

authors： Leon-Carrion J,Martín-Rodríguez JF,Damas-López J,Pourrezai K,Izzetoglu K,Barroso Y Martin JM,Dominguez-Morales MR

更新日期：2007-04-06 00:00:00

abstract：:The critical period for observing a developmentally regulated form of synaptic plasticity in the visual cortex of young rats normally ends at about postnatal day 30. This developmentally regulated form of in vitro long-term potentiation (LTP) can be reliably induced in layers II-III by aiming high frequency, theta bur...

journal_title：Neuroscience letters

authors： Shaffery JP,Lopez J,Bissette G,Roffwarg HP

更新日期：2006-01-02 00:00:00

abstract：:Exposure to negative environmental events triggers defensive behavior and leads to the formation of aversive associative memory. Cellular and molecular changes in the central nervous system underlie this memory formation, as well as the associated behavioral changes. In general, memory process is established in distin...

journal_title：Neuroscience letters

authors： Faria RS,Gutierres LF,Sobrinho FC,Miranda Ido V,Reis JD,Dias EV,Sartori CR,Moreira DA

更新日期：2016-08-15 00:00:00

abstract：:Intellectual disability (ID) is one of the most prevalent chronic developmental brain disorders or phenotype of syndromic ID, affecting nearly 1-2% of the general population worldwide. Over recent decades, tremendous effort and high-throughput platforms have been devised to explore the complex heterogeneity, numerous ...

journal_title：Neuroscience letters

authors： Chen C,Chen D,Xue H,Liu X,Zhang T,Tang S,Li W,Xu X

更新日期：2018-10-15 00:00:00

abstract：:Neural stem cells (NSCs) have been the focus of an intensive effort to direct their differentiation in vitro towards desired neuronal phenotypes for cell replacement therapies. It is thought that NSCs derived from older embryos have limited neurogenic capacity and are restricted towards an astroglial fate. This idea i...

journal_title：Neuroscience letters

authors： Hegarty SV,Spitere K,Sullivan AM,O'Keeffe GW

更新日期：2014-01-24 00:00:00

abstract：:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to...

journal_title：Neuroscience letters

authors： Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JA

更新日期：2004-04-01 00:00:00

abstract：:Previous studies using short-interval paired-pulse TMS have provided valuable insights into physiology of human motor cortex. Depending on the interstimulus interval (ISI) between the two pulses intra-cortical facilitation (ICF) or intra-cortical inhibition (ICI) can be observed. Similar patterns of inhibition and fac...

journal_title：Neuroscience letters

authors： Sparing R,Dambeck N,Stock K,Meister IG,Huetter D,Boroojerdi B

更新日期：2005-07-15 00:00:00

abstract：:Muscle vibration does not affect post-synaptic excitability of the corresponding motoneuronal pool, the concurrent depression of the monosynaptic reflex resulting from a pre-motoneuronal block of Ia spindle afferents. Indeed (1) both homonymous and heteronymous soleus responses (to electrical stimulation of the poster...

journal_title：Neuroscience letters

authors： Abbruzzese M,Minatel C,Faga D,Favale E

更新日期：1997-08-08 00:00:00

abstract：:The magnetic cell sorter (MACS) technique was applied to isolate retinal ganglion cells (RGCs) for culture. RGCs were labeled retrogradely with 1.1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil). Subsequently retinal cell suspensions were incubated with biotinylated anti-rat Thy-1 antibody and MA...

journal_title：Neuroscience letters

authors： Shoge K,Mishima HK,Mukai S,Shinya M,Ishihara K,Kanno M,Sasa M

更新日期：1999-01-08 00:00:00

abstract：:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

journal_title：Neuroscience letters

authors： Chamas F,Serova L,Sabban EL

更新日期：1999-06-04 00:00:00

abstract：:A well-known event-related potential (ERP) component-the recognition potential (RP) is a response to recognizable stimuli, peaking at around 200-250 ms. The aim of the present study is to put to the test the contrasting perceptual and semantic accounts of the RP, with manipulation of word meaning and presentation form...

journal_title：Neuroscience letters

authors： Zhang Y,Liu Q,Zhang Q

更新日期：2009-04-17 00:00:00