Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type.

abstract：:The aim of the study was to investigate whether repetitive/temporal hypoxia up-regulated P-glycoprotein (P-gp) in cultured rat brain microvascular endothelial cells (rBMECs). Cultured rBMECs were used as in vitro blood brain barrier (BBB) model. Cells reached confluence were subjected to temporal hypoxic exposure. Und...

journal_title：Neuroscience letters

authors： Xiao-Dong L,Zhi-Hong Y,Hui-Wen Y

更新日期：2008-02-27 00:00:00

abstract：:Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese popula...

journal_title：Neuroscience letters

authors： Hu X,Mao C,Hu Z,Zhang Z,Zhang S,Yang Z,Fan Y,Fan L,Zheng H,Yang J,Liu Y,Yuan Y,Wang Y,Shi C,Xu Y

更新日期：2020-04-23 00:00:00

abstract：:The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...

journal_title：Neuroscience letters

authors： Deisz RA,Dose M,Lux HD

更新日期：1984-06-29 00:00:00

abstract：:Extracellular choline-dependency of acetylcholine (ACh) synthesis was examined in rat hippocampal slices. In the presence of hemicholinium-3 (HC-3, 5 microM), extracellular choline-dependent ACh synthesis appeared to consist of two different components. The first component (saturated at up to 50 microM choline) was de...

journal_title：Neuroscience letters

authors： Suzuki T,Kashima Y,Kawashima K

更新日期：1989-10-23 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of amyloid beta-peptide (Abeta), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We analyzed the effects...

journal_title：Neuroscience letters

authors： Tanabe C,Ebina M,Asai M,Futai E,Sasagawa N,Katano K,Fukami H,Ishiura S

更新日期：2009-02-06 00:00:00

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:An excess accumulation of advanced glycation end products (AGEs) has been reported in autism brains. Through their interaction with their putative receptor RAGE, AGEs can promote neuroinflammation, oxidative stress and neuronal degeneration. To shed more light on the possible alterations of the AGEs-RAGE axis in autis...

journal_title：Neuroscience letters

authors： Boso M,Emanuele E,Minoretti P,Arra M,Politi P,Ucelli di Nemi S,Barale F

更新日期：2006-12-27 00:00:00

abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...

journal_title：Neuroscience letters

authors： Alvarez P,Levine JD,Green PG

更新日期：2015-03-30 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) in the concentration of 1 microM or less markedly and selectively increased the amplitude and duration of the muscarinic slow excitatory postsynaptic potential (EPSP) without appreciably affecting the nicotinic fast EPSP or the non-cholinergic EPSP of guinea pig inferior mesente...

journal_title：Neuroscience letters

authors： Mo N,Dun NJ

更新日期：1984-11-23 00:00:00

abstract：:Huntingtin-associated protein 1 (HAP1) interacts with the product of the Huntington's disease gene. To investigate the function of Hap1 in development and in the adult mouse, we have examined the expression of Hap1 by northern analysis and in situ hybridization histochemistry. Hap1 expression is first detected in the ...

journal_title：Neuroscience letters

authors： Dragatsis I,Dietrich P,Zeitlin S

更新日期：2000-03-17 00:00:00

abstract：:The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

journal_title：Neuroscience letters

authors： Patel MA,Katyare SS

更新日期：2006-07-10 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) plays an important role in the regulation of energy balance. While the regulation of TRH in the paraventricular nucleus (PVN) in response to changes of energy balance has been well studied, how TRH is regulated in the dorsomedial hypothalamus (DMH) in maintaining energy homeostasis ...

journal_title：Neuroscience letters

authors： Zhang N,Zhang HY,Bi SA,Moran TH,Bi S

更新日期：2019-06-11 00:00:00

abstract：:To investigate the role of Cl(-)-stimulated Mg(2+)-ATPase (Cl(-)-ATPase) in neurons, we examined the effects of ethacrynic acid (0.3 mM), which completely inhibits Cl(-)-ATPase on the intracellular Cl- concentrations of cultured rat hippocampal neurons, using Cl(-)-sensitive fluorescent probes. Ethacrynic acid and ATP...

journal_title：Neuroscience letters

authors： Inoue M,Hara M,Zeng XT,Hirose T,Ohnishi S,Yasukura T,Uriu T,Omori K,Minato A,Inagaki C

更新日期：1991-12-16 00:00:00

abstract：:The angular distribution of mitotic spindle fibers has been studied in the telencephalic ventricular zone (VZ) of mouse embryos and has been found to be monophasic and invariant during the early cortical histogenesis both in the normal and in a reeler embryo. This observation suggests that the orientation of mitotic s...

journal_title：Neuroscience letters

authors： Landrieu P,Goffinet A

更新日期：1979-06-01 00:00:00

abstract：:Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia. In the present study we modeled migraine headache by intraperitoneal (i.p.) injection of a single dose of NTG, which produced widespread therma...

journal_title：Neuroscience letters

authors： Farajdokht F,Babri S,Karimi P,Mohaddes G

更新日期：2016-09-06 00:00:00

abstract：:Songbirds and humans use auditory feedback to acquire and maintain their vocalizations. The Bengalese finch (Lonchura striata domestica) is a songbird species that rapidly modifies its vocal output to adhere to an internal song memory. In this species, the left side of the bipartite vocal organ is specialized for prod...

journal_title：Neuroscience letters

authors： Urbano CM,Peterson JR,Cooper BG

更新日期：2013-02-08 00:00:00

abstract：:This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

journal_title：Neuroscience letters

authors： Luo J,Wang Y,Li W,Long L,Cao H

更新日期：2020-06-29 00:00:00

abstract：:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

journal_title：Neuroscience letters

authors： McCartney AM,Abejuela VL,Isaacson LG

更新日期：2008-08-01 00:00:00

abstract：:To evaluate the roles of complement in kainic acid (KA)-induced neuronal damages, the immunohistochemical localization of the complement protein C3 was examined in rat hippocampus after systemic KA injection. The immunoreactivity for C3 was found in glial cells in control rats, and such glial cells were increased in n...

journal_title：Neuroscience letters

authors： Morita H,Suzuki K,Mori N,Yasuhara O

更新日期：2006-11-27 00:00:00

abstract：:During hyperalgesia there is an enhancement of wind-up and the appearance of a novel wind-up of the A-fibre-mediated responses. We have examined if these phenomena are influenced by supraspinal mechanisms by analysing single motor unit activity in control and arthritic rats, either intact or acutely spinalised. Enhanc...

journal_title：Neuroscience letters

authors： Herrero JF,Cervero F

更新日期：1996-05-03 00:00:00

abstract：:In order to study the influence of curare and atropine on the gamma-aminobutyric acid (GABA)-evoked chloride current, we have investigated cultures of hippocampal and septal region neurons from embryonic rats (E18). The neurons were cultured under the trophic influence of spatially separated astrocytes in serum-free m...

journal_title：Neuroscience letters

authors： Siebler M,Köller H,Schmalenbach C,Müller HW

更新日期：1988-11-11 00:00:00

abstract：:Visual mental imagery is a process that draws on different cognitive abilities and is affected by the contents of mental images. Several studies have demonstrated that different brain areas subtend the mental imagery of navigational and non-navigational contents. Here, we set out to determine whether there are distinc...

journal_title：Neuroscience letters

authors： Boccia M,Piccardi L,Palermo L,Nemmi F,Sulpizio V,Galati G,Guariglia C

更新日期：2014-09-05 00:00:00

abstract：:Iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate (ATP) and adenosine 5'-monophosphate (AMP) have been tested on rat cerebral cortical neurons. 2-Azido-AMP and 2-azido-ATP had a powerful depressant action on the spontaneous firing of cortical neurons. Both compounds were equipotent...

journal_title：Neuroscience letters

authors： Phillis JW

更新日期：1981-01-01 00:00:00

abstract：:Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this fam...

journal_title：Neuroscience letters

authors： Takano T,Sahara N,Yamanouchi Y,Mori H

更新日期：1997-01-17 00:00:00

abstract：:Partial depolarization of primary cerebellar neuronal cultures with K+ evoked the release of aspartate, glutamate, adenosine, serine, taurine, gamma-aminobutyric acid (GABA), alanine and proline. The dihydropyridine calcium channel agonist, BAY K 8644, significantly augmented the K+-induced release of adenosine, aspar...

journal_title：Neuroscience letters

authors： Philibert RA,Dutton GR

更新日期：1989-07-17 00:00:00

abstract：:The slow Wallerian degeneration protein (WldS), a fusion protein containing amino-terminal E4B and full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by physical damages, toxins and genetic mutations which result in patients being diagnosed with neurodegenerative di...

journal_title：Neuroscience letters

authors： Watanabe M,Tsukiyama T,Hatakeyama S

更新日期：2007-01-16 00:00:00

abstract：:Circadian firing rhythms of cultured rat suprachiasmatic nucleus were measured simultaneously from 4-8 neurons by using a multi-electrode dish and neuronal interactions were examined by a cross-correlation analysis of spontaneous action potentials. Functional connections were detected in the neuron pairs showing synch...

journal_title：Neuroscience letters

authors： Honma S,Shirakawa T,Nakamura W,Honma K

更新日期：2000-11-17 00:00:00

abstract：:The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...

journal_title：Neuroscience letters

authors： Acar N,Chardigny JM,Berdeaux O,Almanza S,Sébédio JL

更新日期：2002-10-18 00:00:00

abstract：:We compared the modulation of GABA (gamma-aminobutyric acid)-activated currents by benzodiazepines in recombinant GABAA receptors containing either one of two alpha subunits, alpha 1 or alpha 6. Lüddens et al. (Nature, 346 (1990) 648-651) have previously demonstrated that the alpha 6 subunit is part of a cerebellar re...

journal_title：Neuroscience letters

authors： Kleingoor C,Ewert M,von Blankenfeld G,Seeburg PH,Kettenmann H

更新日期：1991-09-16 00:00:00

abstract：:Local warming or cooling of the preoptic and anterior hypothalamus (PO/AH) areas evokes various thermoregulatory responses in mammals. We have hypothesized that warm- and cold-sensitive neurons recorded in the PO/AH are multiple thermostats that regulate the core temperature against heat and cold, respectively. Howeve...

journal_title：Neuroscience letters

authors： Abe J,Okazawa M,Adachi R,Matsumura K,Kobayashi S

更新日期：2003-05-15 00:00:00