Abstract:
:Circadian firing rhythms of cultured rat suprachiasmatic nucleus were measured simultaneously from 4-8 neurons by using a multi-electrode dish and neuronal interactions were examined by a cross-correlation analysis of spontaneous action potentials. Functional connections were detected in the neuron pairs showing synchronized circadian firing rhythms, and when the connections were lost, firing rhythms were desynchronized. After the prolonged treatment with tetrodotoxin, cross-correlation and circadian rhythm synchronization were abolished concomitantly in most neuron pairs. Cellular mechanisms involving Na(+)-channel dependent communication are responsible for the synchronization of the circadian rhythms in individual suprachiasmatic nucleus (SCN) neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Honma S,Shirakawa T,Nakamura W,Honma Kdoi
10.1016/s0304-3940(00)01558-5keywords:
subject
Has Abstractpub_date
2000-11-17 00:00:00pages
113-6issue
2eissn
0304-3940issn
1872-7972pii
S0304394000015585journal_volume
294pub_type
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