Abstract:
:The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein-E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showed dendritic alterations in pyramidal neurons of apolipoprotein-E4 transgenic mice, similar to the ones observed in apolipoprotein E-deficient mice. However, these mice had a preserved density of synaptophysin-immunoreactive presynaptic terminals. In contrast, mice overexpressing apolipoprotein-E3 showed no synapto-dendritic alterations. Analysis of behavioral performance in the Morris water maze showed that while apolipoprotein E-deficient mice performed poorly, overexpression of apolipoprotein-E3 and, to a lower extent apolipoprotein-E4, resulted in an improved performance. This study supports the contention that, compared with apolipoprotein-E4, apolipoprotein-E3 might have a greater neurotrophic in vivo effect in aged mice.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Veinbergs I,Mallory M,Mante M,Rockenstein E,Gilbert JR,Masliah Edoi
10.1016/s0304-3940(99)00243-8keywords:
subject
Has Abstractpub_date
1999-04-23 00:00:00pages
218-22issue
3eissn
0304-3940issn
1872-7972pii
S0304394099002438journal_volume
265pub_type
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