Radioautographic evidence that axons from the area of supraoptic nuclei in the rat project to extrahypothalamic brain regions.

Abstract:

:The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the visualized labeled axonal bundles were found to project into various extrahypothalamic regions, including the olfactory bulb, the cortex, the lateral habenula, the subcommissural organ, the amygdala, the mammillary bodies and the locus coeruleus. These results suggest that part of the vasopressin- or oxytocin-containing perikarya located in the supraoptic nucleus constitute the cells of origin of axons which also contain these peptides and which have already been shown to be present in the above extrahypothalamic areas. This also implies that, like the paraventricular nucleus, the supraoptic nucleus is also involved in central extrahypothalamic regulations.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Alonso G,Szafarczyk A,Assenmacher I

doi

10.1016/0304-3940(86)90027-3

subject

Has Abstract

pub_date

1986-05-23 00:00:00

pages

251-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90027-3

journal_volume

66

pub_type

杂志文章
  • Nerve growth factor (NGF) in rat brain following long-term barbital treatment: relation to convulsions and cognitive function.

    abstract::Nerve growth factor (NGF) protein has been implicated in alterations of cognitive function either following brain damage, selective lesions or aging. Groups of rats were given long-term (48 weeks) oral barbital treatment or tap water and following an extended period of abstinence (14 weeks) were tested for spatial lea...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90299-m

    authors: Wahlström G,Archer T,Lärkfors L

    更新日期:1992-03-16 00:00:00

  • The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells.

    abstract::Mutations in presenilins are the major cause of early onset familial Alzheimer disease. It has recently been argued that clinical presenilin mutations work as loss-of-function but not toxic gain-of-function. To investigate whether presenilins are involved in the regulation of the distribution of neuronal membrane lipi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.07.027

    authors: Oikawa N,Goto M,Ikeda K,Taguchi R,Yanagisawa K

    更新日期:2012-09-06 00:00:00

  • Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.

    abstract::Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.11.031

    authors: Kim OJ,Hong SH,Jeon YJ,Oh SH,Kim HS,Park YS,Kim EJ,Kim NK

    更新日期:2013-01-15 00:00:00

  • Aging of the cingulum in the human brain: Preliminary study of a diffusion tensor imaging study.

    abstract::The cingulum, a major structure of the limbic system, is closely associated with memory function. In the current study, we investigated aging of the cingulum according to the location of the cingulum in each part of the cingulum after dividing the cingulum into five parts in normal subjects, using DTT parameters (frac...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.11.018

    authors: Jang SH,Kwon YH,Lee MY,Kim JR,Seo JP

    更新日期:2016-01-01 00:00:00

  • The effect of ketamine anesthetic induction on muscle responses to transcranial magnetic cortex stimulation studied in man.

    abstract::In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90182-k

    authors: Kothbauer K,Schmid UD,Liechti S,Rösler KM

    更新日期:1993-05-14 00:00:00

  • Growth-associated protein-43 is elevated in the injured rat sciatic nerve after low power laser irradiation.

    abstract::Low power laser irradiation (LPLI) has been used in the treatment of peripheral nerve injury. In this study, we verified its therapeutic effect on neuronal regeneration by finding elevated immunoreactivities (IRs) of growth-associated protein-43 (GAP-43), which is up-regulated during neuronal regeneration. Twenty Spra...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00354-9

    authors: Shin DH,Lee E,Hyun JK,Lee SJ,Chang YP,Kim JW,Choi YS,Kwon BS

    更新日期:2003-06-26 00:00:00

  • Mapping of estrogen receptor-producing cells in the rat brain by in situ hybridization.

    abstract::The localization of cells which produce estrogen receptors in the rat central nervous system was performed using an in situ hybridization technique. For this, we used a synthetic oligonucleotide probe labeled with 35S complementary to the mRNA coding for a fragment (1-24) of estradiol receptor which is not common to t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90264-9

    authors: Pelletier G,Liao N,Follea N,Govindan MV

    更新日期:1988-11-22 00:00:00

  • Effect of different regions of Nogo-A on the differentiation of neural progenitors.

    abstract::Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regio...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.04.034

    authors: Gao Y,Xiao Z,Chen B,Wang B,Han J,Zhao Y,Zhang J,Dai J

    更新日期:2009-07-24 00:00:00

  • Genetic analysis of lysosomal alpha-galactosidase A gene in sporadic Parkinson's disease.

    abstract::Parkinson's disease (PD) is a progressive neurodegenerative disease. Majority of PD cases are sporadic, resulting from interaction of genetic and environmental factors. Accumulating evidence indicates that autophagy, which delivers alpha-synuclein to lysosomes for degradation, is involved in the PD pathogenesis. Some ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.05.238

    authors: Wu G,Pang S,Feng X,Zhang A,Li J,Gu K,Huang J,Dong H,Yan B

    更新日期:2011-08-01 00:00:00

  • An intermediate conductance calcium-activated potassium channel in rat visceral sensory afferent neurons.

    abstract::Whole-cell and single channel recordings were used to characterize an intermediate conductance calcium-activated potassium (KCa) channel in sensory neurons of the nodose ganglion. From a -80 mV holding potential, the total outward current in these neurons was increased when extracellular calcium was raised from 0.02 t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)91056-1

    authors: Hay M,Kunze DL

    更新日期:1994-02-14 00:00:00

  • Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat.

    abstract::The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90501-w

    authors: Liu H,Llewellyn-Smith IJ,Pilowsky P,Basbaum AI

    更新日期:1992-04-13 00:00:00

  • Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses.

    abstract::Rapid removal of synaptically released glutamate from the extracellular space ensures a high signal-to-noise ratio in excitatory neurotransmission. In the cerebellum, glial glutamate transporters, GLAST and GLT-1, are co-localized in the processes of Bergmann glia wrapping excitatory synapses on Purkinje cells (PCs). ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.04.062

    authors: Takatsuru Y,Iino M,Tanaka K,Ozawa S

    更新日期:2007-06-08 00:00:00

  • Parvalbumin-immunoreactive dystrophic neurites and aberrant sprouts in the cerebral cortex of patients with Alzheimer's disease.

    abstract::Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lob...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90254-i

    authors: Ferrer I,Zújar MJ,Rivera R,Soria M,Vidal A,Casas R

    更新日期:1993-08-20 00:00:00

  • Ethanol induces rapid lipid peroxidation and activation of nuclear factor-kappa B in cerebral vascular smooth muscle: relation to alcohol-induced brain injury in rats.

    abstract::The present study was designed to test the hypothesis that acute administration of alcohol (ethanol) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, inhibition of IkappaB phosphorylation, and inhibition of nuclear transcription factor-kappa B (NF-kappaB). Ethanol (10, 25, 100 m...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00264-1

    authors: Altura BM,Gebrewold A,Zhang A,Altura BT

    更新日期:2002-06-07 00:00:00

  • Transneuronal transport in the visual system of the toad, Bufo marinus.

    abstract::Secondary optic projections were studied in the toad, Bufo marinus using the method of transneuronal transport of triated proline and fucose. Following a survival of 14 days after eye injection autoradiographic label was transported transneuronally to the contralateral nucleus isthmi, the deeper layers of the contrala...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90004-x

    authors: Mayner L

    更新日期:1980-03-01 00:00:00

  • Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury.

    abstract::Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a st...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.11.057

    authors: Park C,Cho IH,Kim D,Jo EK,Choi SY,Oh SB,Park K,Kim JS,Lee SJ

    更新日期:2008-01-31 00:00:00

  • Sensory threshold changes without initial pain or alterations in cutaneous blood flow, in the area of secondary hyperalgesia caused by topical application of capsaicin in humans.

    abstract::Changes in von Frey hair perception, pricking pain, and vibration thresholds were examined in six healthy human adults, in the zone of secondary hyperalgesia, 45 min following the topical application of capsaicin at concentrations of 0.05 and 0.1 mg/ml. In two of these subjects, cutaneous blood flow was monitored at 1...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3940(99)00248-7

    authors: Andrews K,Baranowski A,Kinnman E

    更新日期:1999-04-30 00:00:00

  • The astrocyte marker Aldh1L1 does not reliably label enteric glial cells.

    abstract::Enteric glial cells are increasingly acknowledged as important partners of enteric neurons in the control of gastrointestinal function. They share morphological features and expression of antigenic markers with astrocytes of the central nervous system. Recently, aldehyde dehydrogenase 1 family member L1 (Aldh1L1) has ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.02.042

    authors: Boesmans W,Rocha NP,Reis HJ,Holt M,Vanden Berghe P

    更新日期:2014-04-30 00:00:00

  • Time-variant structure of auditory cortex of the macaque monkey.

    abstract::Supra-threshold responses of neurons in the primary auditory cortex of the macaque monkey are so complex that the characteristic frequency cannot be determined. By statistical analyses based on analysis of variance and principal component analysis, we demonstrated that the similarity of neurons from penetration perpen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11322-n

    authors: Takahashi T

    更新日期:1995-02-24 00:00:00

  • A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.

    abstract::Excessive activation of the N-methyl-D-aspartate (NMDA) receptor-channel complex has been implicated as one of the mechanisms by which ischemia-induced neuronal damage is mediated. Elevated glycine levels during ischemia may contribute to damage mediated by the NMDA receptor as glycine binding potentiates NMDA respons...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90191-9

    authors: Wood ER,Bussey TJ,Phillips AG

    更新日期:1992-09-28 00:00:00

  • Increased beta-amyloid precursor protein mRNA in the rat cerebral cortex and hippocampus after chronic systemic atropine treatment.

    abstract::Rats were treated with once-daily subcutaneous injections of atropine or normal saline for 10 days. Cryostat sections of fresh-frozen brain were subjected to quantitative muscarinic receptor ([3H]quinuclidinylbenzilate (QNB)) binding autoradiography, and quantitative in-situ hybridization autoradiography for beta-amyl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12650-1

    authors: Beach TG,Walker DG,Cynader MS,Hughes LH

    更新日期:1996-05-24 00:00:00

  • Morphine does not reduce the intraspinal release of calcitonin gene-related peptide in the cat.

    abstract::In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaini...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90684-2

    authors: Morton CR,Hutchison WD

    更新日期:1990-09-18 00:00:00

  • Anticonvulsant activity of the noradrenergic locus coeruleus system: role of beta mediation.

    abstract::Many experimental observations have demonstrated the modulatory role exerted by several neural structures and neurotransmitters on spontaneous and paroxysmal bioelectric activity of the hippocampus. Recently, the control exerted by locus coeruleus (LC) and its noradrenergic (NA) efferent pathway on different experimen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90364-6

    authors: Ferraro G,Sardo P,Sabatino M,Caravaglios G,La Grutta V

    更新日期:1994-03-14 00:00:00

  • 14-3-3Zeta does not increase GSK3beta-mediated tau phosphorylation in cell culture models.

    abstract::Tau is a neuronal microtubule-associated protein whose function is regulated by site-specific phosphorylation. One protein kinase that is likely to play an important role in regulating the phosphorylation state of tau in vivo is glycogen synthase kinase (GSK) 3beta. The activity of GSK3beta is regulated by specific pr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.04.101

    authors: Matthews TA,Johnson GV

    更新日期:2005-08-26 00:00:00

  • Sexual dimorphism in song-induced ZENK expression in the medial striatum of juvenile zebra finches.

    abstract::In the brains of male zebra finches (Taeniopygia guttata), the nuclei that direct song learning and production are larger than the corresponding regions in females, who do not sing. The dimorphism in Area X of the medial striatum (MSt), an area important for song learning, is even more dramatic in that it is identifia...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.02.076

    authors: Bailey DJ,Wade J

    更新日期:2006-06-19 00:00:00

  • A fast and simple differentiation protocol to study the pro-neurogenic activity of soluble factors in neurospheres.

    abstract::Sphere-forming assays are widely used for the propagation, characterization and manipulation of adult brain-derived stem- and progenitor cells. However despite the broad application of this cell culture system in neural stem cell- and brain tumor research, no standardized protocols exist. Variations in experimental pr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.01.003

    authors: Schramm J,Schulte D

    更新日期:2014-03-06 00:00:00

  • Influence of change in frequency on the movement of sound sources induced by interaural time differences.

    abstract::When a tone-burst train with a short inter-burst interval is lateralized to the left and is followed by another tone-burst train lateralized to the right, listeners report a smooth shift of tone bursts along the intracranial axis from left to right (known as auditory saltation). When a sequence of tone bursts with a c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.11.020

    authors: Kawabe T

    更新日期:2010-01-14 00:00:00

  • Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.

    abstract::In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90582-t

    authors: Verberne AJ,Widdop RE,Maccarrone C,Jarrott B,Beart PM,Louis WJ

    更新日期:1990-07-13 00:00:00

  • Noxious stimulus-induced increase in spinal prostaglandin E2 is noradrenergic terminal-dependent.

    abstract::Prostaglandins (PGs) were measured in perfusate from the lumbar intrathecal (IT) space of pentobarbital anaesthetized rats. The level of PGE2, but not of PGF2 alpha or 6-keto PGF1 alpha, was increased by immersion of a hindpaw in water at a noxious temperature (50 degrees C). No increase in PGE2 was produced by non-no...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90464-k

    authors: Coderre TJ,Gonzales R,Goldyne ME,West J,Levine JD

    更新日期:1990-07-31 00:00:00

  • The spinal antinociceptive effect of kyotorphin in mice: involvement of the descending noradrenergic and serotonergic systems.

    abstract::The role of descending monoaminergic systems in the antinociceptive effect of kyotorphin (Tyr-Arg, KTP) was investigated in mice by means of the tail-pinch test. We compared this effect with that of the delta-opioid receptor agonist [D-Pen(2,5)]-enkephalin (DPDPE). The antinociceptive effect of KTP and DPDPE injected ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00647-x

    authors: Ochi T,Ohkubo Y,Mutoh S

    更新日期:2002-08-30 00:00:00