Abstract：
:Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regions of Nogo-A and show two of them also mediate the differentiation of neural progenitors. A 172-residues N-terminal region and a 37-residues C-terminal region of Nogo-A both could inhibit neuronal differentiation and promoted glial cell formation. This study illustrated that Nogo-A had multiple functional domains on the behavior of neuronal cells. The inhibitory effect of neural differentiation of Nogo-A may also contribute to its restraint of CNS repair.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gao Y,Xiao Z,Chen B,Wang B,Han J,Zhao Y,Zhang J,Dai Jdoi
10.1016/j.neulet.2009.04.034subject
Has Abstractpub_date
2009-07-24 00:00:00pages
132-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00503-5journal_volume
458pub_type
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-05-20 00:00:00
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pub_type： 杂志文章
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