Abstract：
:Tau is a neuronal microtubule-associated protein whose function is regulated by site-specific phosphorylation. One protein kinase that is likely to play an important role in regulating the phosphorylation state of tau in vivo is glycogen synthase kinase (GSK) 3beta. The activity of GSK3beta is regulated by specific protein-protein interactions and 14-3-3zeta, a member of a protein family that can act as scaffolds, was recently reported to co-purify with GSK3beta in a large protein complex that was isolated from bovine brain [A. Agarwal-Mawal, H.Y. Qureshi, P.W. Cafferty, Z. Yuan, D. Han, R. Lin, H.K. Paudel, 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex, J. Biol. Chem. 278 (2003) 12722-12728]. The purpose of this study was to determine if 14-3-3zeta could act as a scaffolding protein to promote the interaction of GSK3beta with tau and subsequently, enhance GSK3beta-mediated tau hyperphosphorylation. We used cell culture models, immunoprecipitation, and Western blotting to examine the interaction of GSK3beta and 14-3-3zeta with both exogenously and endogenously expressed proteins. We found that GSK3beta, 14-3-3zeta and tau do not interact in these cellular models under our experimental conditions and that GSK3beta-mediated tau phosphorylation is not effected by the presence of 14-3-3zeta. These data indicate that 14-3-3zeta may not be directly interacting with GSK3beta and tau in the brain, but may indirectly facilitate the interactions by binding to other proteins.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Matthews TA,Johnson GVdoi
10.1016/j.neulet.2005.04.101keywords:
subject
Has Abstractpub_date
2005-08-26 00:00:00pages
211-6issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00592-6journal_volume
384pub_type
杂志文章abstract：:Normal treatment of rats with monosodium-L-glutamate (MSG) resulted in extensive degeneration of the inner nuclear layer of the retina. The retino-hypothalamic projection was still functional as these rats entrained their circadian food intake rhythm to the light-dark cycle. A normal proportion of dorsal lateral genic...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90407-9
更新日期：1981-09-25 00:00:00
abstract：:A non-calcium-dependent chloride channel of conductance 62 pS, found in isolated inside-out patches of cultured fetal rat hippocampal neurons, is described. The channel does not require the presence of any neurotransmitter to be active and probably plays a part in maintaining the normal resting membrane potential. ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90208-q
更新日期：1990-05-04 00:00:00
abstract：:We have used Lucifer Yellow for histological tracing of displaced amacrine cells within the ganglion cell layer (GCL) during the embryonic development of the chicken retina. Incubating whole eyes in the dye leads to bright staining of all displaced amacrine cells, whereas ganglion cells and glial cells are not stained...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90099-4
更新日期：1982-08-16 00:00:00
abstract：:The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00879-0
更新日期：2002-10-18 00:00:00
abstract：:The role of descending monoaminergic systems in the antinociceptive effect of kyotorphin (Tyr-Arg, KTP) was investigated in mice by means of the tail-pinch test. We compared this effect with that of the delta-opioid receptor agonist [D-Pen(2,5)]-enkephalin (DPDPE). The antinociceptive effect of KTP and DPDPE injected ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00647-x
更新日期：2002-08-30 00:00:00
abstract：:The goal of the present study was to explore the relation between speed-accuracy trade-off phenomena and action kinematics in the case of pointing under isometric conditions. Increasing task difficulty resulted in a linear increase in movement time (as predicted by Fitts' law) and in systematic changes in the spatio-t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01089-2
更新日期：2000-05-26 00:00:00
abstract：:Face processing is unique to human beings and is likely to have special neuronal properties. We studied one of these properties, categorical representation of the face in perception processing (perception) and in memory recall processing (imagery), using the face and building stimuli. The same building-selective areas...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.09.053
更新日期：2008-12-19 00:00:00
abstract：:Nitric oxide (NO) from endothelial or neuronal NO synthases (eNOS or nNOS) may contribute both to the cerebrovascular responses to oxygen and potentially to the peroxynitrite-mediated toxic effects of hyperbaric oxygen (HBO(2)) on the central nervous system (CNS O(2) toxicity). In mice lacking eNOS or nNOS (-/-), regi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00432-4
更新日期：2003-06-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)13326-2
更新日期：1997-01-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.10.060
更新日期：2006-02-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.12.002
更新日期：2009-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.05.074
更新日期：2009-09-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.04.005
更新日期：2017-05-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.08.043
更新日期：2009-10-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.10.008
更新日期：2006-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90210-1
更新日期：1985-08-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12555-6
更新日期：1996-04-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)91525-8
更新日期：1979-11-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.11.022
更新日期：2006-03-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90585-4
更新日期：1987-06-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90085-2
更新日期：1989-07-31 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90299-9
更新日期：1983-09-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90009-x
更新日期：1990-02-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.11.020
更新日期：2004-02-06 00:00:00
abstract：:Genome-wide analysis of miRNA expression has revealed increased levels of miR-144 in the brains of Alzheimer's disease (AD) patients. Nuclear factor erythroid 2-related factor 2 (NRF2), a potential target of miR-144, is a central regulator of antioxidant response, and plays an important role in glutathione (GSH) biosy...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.06.045
更新日期：2017-08-10 00:00:00
abstract：:Perception of limb position and motion is abnormal in Parkinson's disease (PD). Despite the fact that the processing of proprioceptive inputs is inherently temporal, most studies have assessed spatial aspects of proprioception in PD patients. Here, we use a recently described method to test whether deficits also exist...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.02.050
更新日期：2007-05-07 00:00:00
abstract：:To explore the possible cellular source and mechanism of apolipoprotein E (apoE) expression in mechanical injured neuronal cultures. Primary cultured mouse cortical neurons were subjected into mechanical injury by needle scratching. The conditioned medium of wild type (WT) primary mouse astrocytes was collected and ad...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.03.023
更新日期：2012-04-25 00:00:00
abstract：:Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)96156-1
更新日期：1979-10-01 00:00:00
abstract：:The organisation of corticofugal fibres within the basis pedunculi of rats was studied using wheat germ agglutinin-horseradish peroxidase as an orthograde tracer. Following cortical injections, labelled fibres were distributed within the cerebral peduncle in an orderly way. Fibres which originate from cells in the fro...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90139-x
更新日期：1992-01-20 00:00:00
abstract：:The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin. Ro 15-1788, a benzodiazepine receptor antagonist, rever...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90505-1
更新日期：1985-06-24 00:00:00
