Abstract:
:In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs. The time courses of fall in MAP and HR and hindlimb paralysis were similar. Baroreceptor-HR reflex activity was also markedly impaired after KYN, suggesting functional diminution of sympathetic outflow at the level of the spinal cord after blockade of EAA receptors by KYN. Xanthurenate, a metabolite of KYN without EAA antagonistic properties, produced negligible effects at the same dose of KYN. While these findings do not identify the putative EAA pathway, they do provide the first demonstration that this system is tonically active in conscious rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Verberne AJ,Widdop RE,Maccarrone C,Jarrott B,Beart PM,Louis WJdoi
10.1016/0304-3940(90)90582-tsubject
Has Abstractpub_date
1990-07-13 00:00:00pages
309-15issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(90)90582-Tjournal_volume
114pub_type
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