Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.

Abstract:

:In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs. The time courses of fall in MAP and HR and hindlimb paralysis were similar. Baroreceptor-HR reflex activity was also markedly impaired after KYN, suggesting functional diminution of sympathetic outflow at the level of the spinal cord after blockade of EAA receptors by KYN. Xanthurenate, a metabolite of KYN without EAA antagonistic properties, produced negligible effects at the same dose of KYN. While these findings do not identify the putative EAA pathway, they do provide the first demonstration that this system is tonically active in conscious rats.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Verberne AJ,Widdop RE,Maccarrone C,Jarrott B,Beart PM,Louis WJ

doi

10.1016/0304-3940(90)90582-t

subject

Has Abstract

pub_date

1990-07-13 00:00:00

pages

309-15

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90582-T

journal_volume

114

pub_type

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