Role of protein kinases A and C in the induction of mGluR-dependent long-term depression in the medial perforant path of the rat dentate gyrus in vitro.

abstract：:Afferent fibers ending in nerve-end neuromas generate spontaneous impulse discharge which has been implicated as a cause of paraesthesias and pain following peripheral nerve injury in man. We now show in rats that the anticonvulsant drug phenytoin (PT), applied systemically or topically onto desheathed neuromas, suppr...

journal_title：Neuroscience letters

authors： Yaari Y,Devor M

更新日期：1985-07-04 00:00:00

abstract：:Nitric oxide synthase-immunoreactivity (NOS-IR) was detected in strands of nerve fibers entering the rat superior cervical ganglia (SCG) and in nerve fibers forming a plexus beneath the capsule of adrenal glands. Within the SCG, varicose NOS-IR fibers encircled virtually all postganglionic neurons and small diameter c...

journal_title：Neuroscience letters

authors： Dun NJ,Dun SL,Wu SY,Förstermann U

更新日期：1993-08-06 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) has been known as an oscillator of circadian rhythm and recently some reports suggested that excitatory amino acids were functioning in this nucleus. The purpose of this study is to measure the physiological amino acid content of this nucleus, to estimate the circadian variation in am...

journal_title：Neuroscience letters

authors： Takeuchi Y,Takahashi K

更新日期：1994-09-12 00:00:00

abstract：:Nitric oxide (NO) plays a role in the secondary damage after spinal cord (SC) injury. NO is produced by the activity of two classes of enzymes: calcium-dependent constitutive nitric oxide synthase (NOS) and calcium-independent inducible NOS. To determine the time course of both NOS activities after SC injury, 50 Wista...

journal_title：Neuroscience letters

authors： Díaz-Ruiz A,Ibarra A,Pérez-Severiano F,Guízar-Sahagún G,Grijalva I,Ríos C

更新日期：2002-02-22 00:00:00

abstract：:Following virus infection of the central nervous system, microglia become activated and undergo morphological as well as functional transformations, thereby initiating effective antiviral actions. Herein, we have examined the contribution of nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK)...

journal_title：Neuroscience letters

authors： Nakamichi K,Saiki M,Kitani H,Kuboyama Y,Morimoto K,Takayama-Ito M,Kurane I

更新日期：2007-03-13 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species that has been implicated in various neurodegenerative diseases. Quercetin, one of the plant flavonoids, has been reported to harbor various physiological properties including antioxidant activity. In this study, we investigated the neuroprotective effects...

journal_title：Neuroscience letters

authors： Suematsu N,Hosoda M,Fujimori K

更新日期：2011-10-31 00:00:00

abstract：:We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

journal_title：Neuroscience letters

authors： Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

更新日期：2012-09-27 00:00:00

abstract：:The neuron-specific phosphoprotein B-50 (GAP-43) is associated with neuritogenesis during development and regeneration. We monitored B-50 in cultured spinal neurons (fetal rat) with an enzyme-linked immunoadsorbent assay. B-50 levels increased from 24 to 72 h, then decreased. Other cultures, fixed at 24 h intervals an...

journal_title：Neuroscience letters

authors： van der Neut R,Oestreicher AB,Gispen WH,Bär PR

更新日期：1990-02-05 00:00:00

abstract：:Single electrode voltage-clamp recording from CA3 neurons in guinea pig hippocampal slices was applied to study effects of a new GABAB antagonist, CGP 55845A, on (-)baclofen (IBac)- or gamma-aminobutyric acid (IGABA)-induced potassium (K)-currents and on inhibitory postsynaptic K-currents (K-IPSCs) recorded in the pre...

journal_title：Neuroscience letters

authors： Jarolimek W,Demmelhuber J,Bijak M,Misgeld U

更新日期：1993-05-14 00:00:00

abstract：:The mental rotation (MR) task is defined as a discrimination task between mirror-reversed images involving discrepancy in angular orientation. Various studies have shown that the MR task likely causes mental imagery, that is, visual and/or motor imagery, depending on stimulus types. When figures of rotated hands are p...

journal_title：Neuroscience letters

authors： Meng S,Oi M,Sekiyama K,Saito H

更新日期：2016-08-03 00:00:00

abstract：:Serotonin type-3 (5-HT3) receptors are cation permeable membrane receptors which are involved in modulation of calcium entry in neuronal cells. Along with other ion-channels such as the N-methyl-D-aspartate receptor, it appears to be a target for the actions of ethanol and has been the focus of considerable work in th...

journal_title：Neuroscience letters

authors： Li X,DePetrillo PB

更新日期：2002-10-11 00:00:00

abstract：:Lesion-induced degeneration was combined with immunocytochemistry to study, with electron microscopy, the synaptic connectivity between corticothalamic axon terminals from the first and second somatosensory areas and local circuit neurons of the ipsilateral ventrobasal complex (VB), selectively labelled with an antibo...

journal_title：Neuroscience letters

authors： Barbaresi P,Manzoni T

更新日期：2003-03-27 00:00:00

abstract：:Disturbed motor control of the fingers, as revealed by the response to unexpected loading of an object held in a precision grip, or to finger perturbation during isometric holding, has been studied in patients with Huntington's disease (HD) and in normal subjects. In normal subjects unexpected loading elicited a refle...

journal_title：Neuroscience letters

authors： Fellows S,Schwarz M,Schaffrath C,Dömges F,Noth J

更新日期：1997-04-25 00:00:00

abstract：:Social psychological studies have shown that an experience of threat such as an encounter with death-related stimuli and social exclusion results in tuning toward positive emotional information. Neuroimaging studies have also begun to uncover the neural basis of threat coping, and in this literature, the activity of t...

journal_title：Neuroscience letters

authors： Yanagisawa K,Kashima ES,Moriya H,Masui K,Furutani K,Nomura M,Yoshida H,Ura M

更新日期：2013-09-27 00:00:00

abstract：:The objective of the current study was to evaluate structural changes of the corpus callosum (CC) in abstinence methamphetamine (MA) users. Shape and size of the CC in 27 MA users were compared to those of 18 healthy comparison subjects. To define the local curvature and width of the CC, medial model-based shape analy...

journal_title：Neuroscience letters

authors： Oh JS,Lyoo IK,Sung YH,Hwang J,Kim J,Chung A,Park KS,Kim SJ,Renshaw PF,Song IC

更新日期：2005-08-12 00:00:00

abstract：:We have previously used antisense oligodeoxynucleotides (ODN) to the cloned delta opioid receptor (DOR) to inhibit the antinociceptive response to spinally administered delta opioid receptor selective agonists in mice. Here we have examined the effect of DOR antisense ODN treatment on the level of DOR expressed in NG ...

journal_title：Neuroscience letters

authors： Lai J,Riedl M,Stone LS,Arvidsson U,Bilsky EJ,Wilcox GL,Elde R,Porreca F

更新日期：1996-08-09 00:00:00

abstract：:In the present study, we tried to examine whether the 2-deoxy-D-[14C]glucose (2-DG) technique is useful to investigate the metabolic activity of fetal rat brain in the maternal uterus. The result shows that metabolic mapping of the fetal brain was clearly obtained by means of the 2-DG technique. ...

journal_title：Neuroscience letters

authors： Morimoto A,Imai-Matsumura K,Murakami N

更新日期：1990-03-26 00:00:00

abstract：:Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease (AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline i...

journal_title：Neuroscience letters

authors： Schönknecht OD,Hunt A,Toro P,Henze M,Haberkorn U,Schröder J

更新日期：2009-12-25 00:00:00

abstract：:The fine structure of striato-nigral efferent neurons, retrogradely labeled with HRP, was studied. The neuron showed a medium sized ovoid or tri-angular perikaryon. Short or medium lengthened granular endoplasmic reticula, having a tendency to wind and pile up in stacks were observed. This neurons corresponds to a typ...

journal_title：Neuroscience letters

authors： Kaiya H,Okinaga M,Namba M,Shoumura K,Watanabe S

更新日期：1979-09-01 00:00:00

abstract：:The primary component of amyloid deposits found in the brains of patients with Alzheimer's disease is the beta-amyloid protein, a derivative of a much larger precursor protein (beta PP). We have previously reported that overexpression of carboxyl (COOH)-terminal fragments of beta PP from an integrated DNA construct le...

journal_title：Neuroscience letters

authors： Fukuchi K,Sopher B,Furlong CE,Smith AC,Dang N,Martin GM

更新日期：1993-05-14 00:00:00

abstract：:Substance P (SP) stimulates striatal dopamine outflow through a cholinergic muscarinic link. SP-induced increase in acetylcholine (Ach) is concentration-dependent, whereas the stimulation of dopamine outflow is seen only over a limited concentration range. M(1) and M(2) receptor stimulation has opposite effects on dop...

journal_title：Neuroscience letters

authors： Khan S,Whelpton R,Michael-Titus AT

更新日期：2000-11-03 00:00:00

abstract：:To determine whether axonal terminals emanating from the central nucleus of amygdala (Ce) to the parabrachial nucleus (PBN) contain gamma-aminobutyric acid (GABA) as their neurotransmitter, an electron microscopic study was performed employing the combined techniques of WGA-HRP anterograde tracing and post-embedding i...

journal_title：Neuroscience letters

authors： Jia HG,Zhang GY,Wan Q

更新日期：2005-07-01 00:00:00

abstract：:Transcranial direct current (DC) stimulation is a noninvasive brain stimulation technique that is now widely used to improve motor and cognitive function. The neuromodulatory effects of DC is considered to extend to nearby as well as remote brain areas from the site of stimulation because of current flowing into the b...

journal_title：Neuroscience letters

authors： Kunori N,Takashima I

更新日期：2021-01-10 00:00:00

abstract：:Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. Dorsomedial and ventrolateral atypical glomeruli contained similar number of ND/NOS-positive periglomeru...

journal_title：Neuroscience letters

authors： Crespo C,Porteros A,Arévalo R,Briñón JG,Aijón J,Alonso JR

更新日期：1996-03-01 00:00:00

abstract：:A new modification of the nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase reaction was used to study the distribution of a specific subset of neurons in rat striatum. These neurons are known to also contain somatostatin-like immunoreactivity (SLI). We have previously found a heterogeneous distribution o...

journal_title：Neuroscience letters

authors： Kowall NW,Beal MF,Ferrante RJ,Martin JB

更新日期：1985-08-16 00:00:00

abstract：:Multiple sclerosis is a currently incurable inflammatory demyelinating syndrome. Recent reports suggest that bone marrow derived mesenchymal stem cells may have therapeutic potential in experimental models of demyelinating disease, but various alternative mechanisms, ranging from systemic immune effects to local cell ...

journal_title：Neuroscience letters

authors： Gordon D,Pavlovska G,Glover CP,Uney JB,Wraith D,Scolding NJ

更新日期：2008-12-19 00:00:00

abstract：:Iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate (ATP) and adenosine 5'-monophosphate (AMP) have been tested on rat cerebral cortical neurons. 2-Azido-AMP and 2-azido-ATP had a powerful depressant action on the spontaneous firing of cortical neurons. Both compounds were equipotent...

journal_title：Neuroscience letters

authors： Phillis JW

更新日期：1981-01-01 00:00:00

abstract：:[3H]Glibenclamide, a potent ATP-sensitive K+ channel blocker, is a specific ligand for the identification of the sulfonylureas receptors which are closely related to ATP-sensitive K+ channels. In order to determine the pre- or postsynaptic localization of these receptors in the rat hippocampus, we studied the effects ...

journal_title：Neuroscience letters

authors： Tremblay E,Zini S,Ben-Ari Y

更新日期：1991-06-10 00:00:00

abstract：:Nuclear factor kappa B (NF(kappa)B) transcription factor plays a key role in the expression of many genes involved in the inflammatory process. We used the Freund's Complete Adjuvant (FCA)-induced model of peripheral inflammation to investigate the anti-inflammatory effects of double stranded oligodeoxynucleotides (OD...

journal_title：Neuroscience letters

authors： Igwe OJ

更新日期：2005-06-10 00:00:00