Abstract:
:To determine whether axonal terminals emanating from the central nucleus of amygdala (Ce) to the parabrachial nucleus (PBN) contain gamma-aminobutyric acid (GABA) as their neurotransmitter, an electron microscopic study was performed employing the combined techniques of WGA-HRP anterograde tracing and post-embedding immunocytochemistry for GABA. Our analysis distinguished a large population of GABA immunopositive axonal terminals from the Ce that exhibited symmetrical synaptic contacts with neurons in the lateral parabrachial nucleus. Additionally, most retrogradely labeled dendrites and perikarya received synaptic contacts from GABA immunoreactive terminals, with some of them originating from the Ce. The present study provides the first direct ultrastructural evidence for a monosynaptic, GABAergic link between Ce axons and neurons of the parabrachial nucleus via classical symmetrical synapses.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jia HG,Zhang GY,Wan Qdoi
10.1016/j.neulet.2005.03.013keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
153-7issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00304-6journal_volume
382pub_type
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