Abstract:
:Lesion-induced degeneration was combined with immunocytochemistry to study, with electron microscopy, the synaptic connectivity between corticothalamic axon terminals from the first and second somatosensory areas and local circuit neurons of the ipsilateral ventrobasal complex (VB), selectively labelled with an antibody raised against gamma-aminobutyric acid (GABA). Four days from the cortical ablation many degenerating axon terminals, forming asymmetric synapses, were found on dendritic trees of both labelled and unlabelled neurons of VB and occasionally on presynaptic dendrites. The main finding of the present paper is that 64.01% of degenerating axon terminals synapsed with GABA-immunopositive dendrites, suggesting that the principal target of the cortical projection to VB are local circuit neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Barbaresi P,Manzoni Tdoi
10.1016/s0304-3940(03)00022-3keywords:
subject
Has Abstractpub_date
2003-03-27 00:00:00pages
211-4issue
3eissn
0304-3940issn
1872-7972pii
S0304394003000223journal_volume
339pub_type
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