Abstract:
:Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions were low. Abnormalities in ganglioside long-chain bases in adult human brain have been reported previously only in patients with inherited metabolic disorders. These abnormalities in C-J disease seem to be closely related to the cause of the disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tamai Y,Ohtani Y,Miura S,Narita Y,Iwata T,Kaiya H,Namba Mdoi
10.1016/0304-3940(79)90060-0subject
Has Abstractpub_date
1979-01-01 00:00:00pages
81-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(79)90060-0journal_volume
11pub_type
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