Abstract：
:Substance P (SP) stimulates striatal dopamine outflow through a cholinergic muscarinic link. SP-induced increase in acetylcholine (Ach) is concentration-dependent, whereas the stimulation of dopamine outflow is seen only over a limited concentration range. M(1) and M(2) receptor stimulation has opposite effects on dopamine outflow. We postulated that the effect of SP on dopamine outflow depends on the M(1)/M(2) balance. We show that Ach (10-2500 microM) stimulates dopamine outflow in striatal slices in a biphasic manner, similar to SP (0.01-100 nM). An inactive SP concentration (10 nM) which was higher than the active concentration range, became active in the presence of the M(2) antagonist methoctramine (100 microM). Conversely, the effect of 1 nM SP was reversed by the M(1) antagonist pirenzepine (1 microM). Our observations show that SP modulation of dopamine outflow is determined by a balance between M(1) and M(2) receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Khan S,Whelpton R,Michael-Titus ATdoi
10.1016/s0304-3940(00)01529-9keywords:
subject
Has Abstractpub_date
2000-11-03 00:00:00pages
179-82issue
3eissn
0304-3940issn
1872-7972pii
S0304394000015299journal_volume
293pub_type
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