Abstract:
:Repeated treatment with dl-pentazocine (5-10 mg/kg i.p.), but not d-methamphetamine (4.8 mg/kg i.p.), twice daily for 8 days diminished the specific [3H]1,3-di-o-tolylguanidine (DTG) binding to the haloperidol-sensitive sigma sites in rat striatum and hippocampus. Either drug failed to cause any changes in the binding to the hypothalamus and prefrontal cortex. The pentazocine-induced diminution in the striatum was accompanied by a decrease in the density with an increase in the affinity of the [3H]DTG binding. These data suggest that repetitive use of dl-pentazocine may influence the regulation systems of the sigma site in specific brain regions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shirayama Y,Nishikawa T,Takahashi Kdoi
10.1016/0304-3940(94)90749-8subject
Has Abstractpub_date
1994-01-03 00:00:00pages
219-22issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90749-8journal_volume
165pub_type
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