Abstract：
:PC12 rat pheochromocytoma cells undergo programmed cell death or apoptosis with DNA fragmentation when deprived of serum. Here, we isolated a subclone of PC12, PC12FrR, that was resistant to DNA fragmentation in a serum-free condition. PC12FrR grew slightly faster, and had cells that were slightly larger than parental PC12 cells. Adenovirus E1A gene-transfected PC12FrR cells grew much faster than did parental PC12FrR cells in the presence of serum. In a serum-deprived condition, E1A-transfected PC12FrR cells died with DNA fragmentation, as did PC12 cells under the same conditions. These results suggest that the target(s) of E1A gene products may be involved in the mechanism(s) that regulate growth and death of neuronal cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sawada M,Kondo N,Marunouchi Tdoi
10.1016/0304-3940(95)11585-ksubject
Has Abstractpub_date
1995-05-26 00:00:00pages
173-6issue
3eissn
0304-3940issn
1872-7972pii
030439409511585Kjournal_volume
191pub_type
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