Abstract:
:The effect of capsaicin was studied on non-cholinergic inhibitory postsynaptic currents (IPSC). The experiments were performed on an identified snail neurone using the single electrode voltage-clamp technique. The IPSC decayed with a bi-exponential time course. Capsaicin (200 microM) reversibly blocked both components of the transmitter-activated potassium conductance similarly to other potassium channel blockers such as Ba2+, quinine or 4-aminopyridine. Externally applied TEA+ exclusively attenuated the slow phase. Capsaicin prolonged the action potential duration and decreased the membrane outward current in the postsynaptic neurone.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Erdélyi L,Such Gdoi
10.1016/0304-3940(84)90332-xsubject
Has Abstractpub_date
1984-03-09 00:00:00pages
75-9issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(84)90332-Xjournal_volume
45pub_type
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