The priming of priming: Evidence that the N400 reflects context-dependent post-retrieval word integration in working memory.


:Which cognitive processes are reflected by the N400 in ERPs is still controversial. Various recent articles (Lau et al., 2008; Brouwer et al., 2012) have revived the idea that only lexical pre-activation processes (such as automatic spreading activation, ASA) are strongly supported, while post-lexical integrative processes are not. Challenging this view, the present ERP study replicates a behavioral study by McKoon and Ratcliff (1995) who demonstrated that a prime-target pair such as finger - hand shows stronger priming when a majority of other pairs in the list share the analogous semantic relationship (here: part-whole), even at short stimulus onset asynchronies (250ms). We created lists with four different types of semantic relationship (synonyms, part-whole, category-member, and opposites) and compared priming for pairs in a consistent list with those in an inconsistent list as well as unrelated items. Highly significant N400 reductions were found for both relatedness priming (unrelated vs. inconsistent) and relational priming (inconsistent vs. consistent). These data are taken as strong evidence that N400 priming effects are not exclusively carried by ASA-like mechanisms during lexical retrieval but also include post-lexical integration in working memory. We link the present findings to a neurocomputational model for relational reasoning (Knowlton et al., 2012) and to recent discussions of context-dependent conceptual activations (Yee and Thompson-Schill, 2016).


Neurosci Lett


Neuroscience letters


Steinhauer K,Royle P,Drury JE,Fromont LA




Has Abstract


2017-06-09 00:00:00












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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dardiotis E,Siokas V,Marogianni C,Aloizou AM,Sokratous M,Paterakis K,Dardioti M,Grigoriadis S,Brotis A,Kapsalaki E,Fountas K,Jagiella J,Hadjigeorgiou GM

    更新日期:2019-03-23 00:00:00

  • Case-control study of vascular endothelial growth factor (VEGF) genetic variability in Alzheimer's disease.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mateo I,Llorca J,Infante J,Rodríguez-Rodríguez E,Sánchez-Quintana C,Sánchez-Juan P,Berciano J,Combarros O

    更新日期:2006-06-19 00:00:00

  • Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus.

    abstract::Immobilization stress induced interleukin-1 beta (IL-1 beta) mRNA in the rat hypothalamus. IL-1 beta mRNA was induced at 30 min after the start of immobilization, reached a maximum at 60 min and then was still detected with a decreased level at 120 min. However, 240 min after the start of the immobilization, IL-1 beta...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    abstract::Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Walker DG,McGeer PL

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Shaikh AG,Finlayson PG

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    journal_title:Neuroscience letters

    pub_type: 杂志文章,随机对照试验


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    更新日期:2014-08-08 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Horváth J,Winkler I

    更新日期:2004-09-23 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Manikandan S,Padma MK,Srikumar R,Jeya Parthasarathy N,Muthuvel A,Sheela Devi R

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  • Phenytoin suppresses spontaneous ectopic discharge in rat sciatic nerve neuromas.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yaari Y,Devor M

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bock AS,Olavarria JF

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: van Veldhuizen MJ,Feenstra MG,Boer GJ,Westerink BH

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Wakade AR,Wakade TD

    更新日期:1984-09-07 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sieghart W,Mayer A

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

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    journal_title:Neuroscience letters

    pub_type: 杂志文章,meta分析


    authors: Jin C,Li W,Yuan J,Xu W,Cheng Z

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Furukawa N,Takasusuki T,Fukushima T,Hori Y

    更新日期:2008-10-17 00:00:00

  • Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kohno K,Higuchi T,Ohta S,Kohno K,Kumon Y,Sakaki S

    更新日期:1997-03-07 00:00:00

  • Age-related changes in histamine receptor mRNA levels in the mouse brain.

    abstract::Several lines of evidence indicate that the histaminergic (HA) system is important for wakefulness and behavioral state regulation. We investigated the hypothesis that age-related changes in HA system occur which may be related to decreased alertness in aging. Although histidine decarboxylase mRNA levels did not chang...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Terao A,Steininger TL,Morairty SR,Kilduff TS

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  • Calcium channel agonist, (+/-)-Bay K8644, causes an immediate increase in the striatal 1-methyl-4-phenylpyridinium level following systemic administration of the dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in Balb/c mice.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Samantaray S,Mohanakumar KP

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Steel JH,Terenghi G,Chung JM,Na HS,Carlton SM,Polak JM

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    abstract::Neurotrophins are a family of growth factor primarily acting in the nervous system, throughout two categories of membrane receptors on the basis of their high (Trk receptors) or low (p75NTR) affinity. Both neurotrophins and Trk receptors are phylogenetically conserved and are expressed not only in the central and peri...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Arai H

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Jurna I,Baldauf J,Zenz M

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zijdewind I,Zwarts MJ,Kernell D

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Behan M,Brownfield MS

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