Specific atrial natriuretic peptide binding sites in rat cerebral capillaries.


:We examined the specific rat 125I-alpha-rat atrial natriuretic peptide(1-28)[ANF-(99-126)] (125I-rANP) binding sites in the cerebral capillaries from the cerebral cortex of male adult Wistar rats. The binding of 125I-rANP at 37 degrees C was saturable and of high affinity with a Kd of approximately 100 pM and Bmax of 152 fmol/mg protein. Divalent cations, Mn2+ (2.2 mM) and Ca2+ (1.8 mM) potently inhibited the binding. The rank order for inhibition of the binding was rANP, alpha-human ANP and ANF-(101-126) greater than ANF-(103-126) and ANF-(103-125)"ANF-(103-123). These data on specific binding sites of ANP in cerebral capillaries suggest a possible role for ANP in the blood-brain permeability of water and electrolytes.


Neurosci Lett


Neuroscience letters


Niwa M,Ibaragi M,Tsutsumi K,Kurihara M,Himeno A,Mori K,Ozaki M




Has Abstract


1988-08-15 00:00:00














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    pub_type: 杂志文章


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