Specific atrial natriuretic peptide binding sites in rat cerebral capillaries.

Abstract:

:We examined the specific rat 125I-alpha-rat atrial natriuretic peptide(1-28)[ANF-(99-126)] (125I-rANP) binding sites in the cerebral capillaries from the cerebral cortex of male adult Wistar rats. The binding of 125I-rANP at 37 degrees C was saturable and of high affinity with a Kd of approximately 100 pM and Bmax of 152 fmol/mg protein. Divalent cations, Mn2+ (2.2 mM) and Ca2+ (1.8 mM) potently inhibited the binding. The rank order for inhibition of the binding was rANP, alpha-human ANP and ANF-(101-126) greater than ANF-(103-126) and ANF-(103-125)"ANF-(103-123). These data on specific binding sites of ANP in cerebral capillaries suggest a possible role for ANP in the blood-brain permeability of water and electrolytes.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Niwa M,Ibaragi M,Tsutsumi K,Kurihara M,Himeno A,Mori K,Ozaki M

doi

10.1016/0304-3940(88)90254-6

subject

Has Abstract

pub_date

1988-08-15 00:00:00

pages

89-94

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90254-6

journal_volume

91

pub_type

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