Specific atrial natriuretic peptide binding sites in rat cerebral capillaries.

abstract：:The aim of this study was to clarify whether 12-lipoxygenase (12-LOX) activation was involved in reactive oxygen species (ROS) generation, extensive poly(ADP-ribose) polymerase (PARP) activation and neuronal death induced by glucose-deprivation, followed by glucose-reload (GD/R). The decrease of neuronal viability and...

journal_title：Neuroscience letters

authors： Nagasawa K,Kakuda T,Higashi Y,Fujimoto S

更新日期：2007-12-18 00:00:00

abstract：:Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...

journal_title：Neuroscience letters

authors： Muscoli C,Visalli V,Colica C,Nisticò R,Palma E,Costa N,Rotiroti D,Nisticò G,Mollace V

更新日期：2005-01-20 00:00:00

abstract：:The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from the...

journal_title：Neuroscience letters

authors： Kuma H,Miki T,Matsumoto Y,Gu H,Li HP,Kusaka T,Satriotomo I,Okamoto H,Yokoyama T,Bedi KS,Onishi S,Suwaki H,Takeuchi Y

更新日期：2004-11-30 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a very important mitogenic factor with proved neurogenesis effects in the central nervous system. Intranasal administration can bypass blood-brain barrier and deliver drugs into the brain directly. We investigated whether intranasal administration of bFGF at later time points a...

journal_title：Neuroscience letters

authors： Wang ZL,Cheng SM,Ma MM,Ma YP,Yang JP,Xu GL,Liu XF

更新日期：2008-11-28 00:00:00

abstract：:Exposure to gestational diabetes (GD) in rats leads to dysplasia of the ventromedial hypothalamic nucleus (VMN), decisively involved into the regulation of body weight and metabolism. Recently, we have shown here that VMN malformation is absent in adult offspring of GD mothers treated by pancreatic islet transplantati...

journal_title：Neuroscience letters

authors： Harder T,Franke K,Fahrenkrog S,Aerts L,Van Bree R,Van Assche FA,Plagemann A

更新日期：2003-12-11 00:00:00

abstract：:It has been shown that Fasciculins (FAS), polypeptides isolated from the venom of the green mamba Dendroaspis angusticeps, provoke a powerful inhibition of peripheral acetylcholinesterase (AChE). In the present study, 0.5 microliter of increasing concentrations (10-500 micrograms/ml) of FAS were injected into the stri...

journal_title：Neuroscience letters

authors： Dajas F,Bolioli B,Castello ME,Silveira R

更新日期：1987-06-01 00:00:00

abstract：:For a flickering light with two or more frequency components, the temporal envelope of the flickering light is perceived, although there is no frequency component at the frequency of the envelope. To address the processing of the temporal envelope, we compared cortical responses to the envelope of amplitude-modulated ...

journal_title：Neuroscience letters

authors： Okamoto Y,Nakagawa S

更新日期：2011-01-07 00:00:00

abstract：:Mental activity which engages one half of the brain is usually accompanied by a suppression of alpha rhythm that is greater over the active hemisphere. When the left hemisphere is active, as during mental arithmetic, the magnitude of the asymmetry in the alpha rhythm is proportional to the rate at which subjects perfo...

journal_title：Neuroscience letters

authors： Glass A,Butler SR

更新日期：1977-03-01 00:00:00

abstract：:The present experiment investigated cortical responses of native Italian subjects during reading of short sentences including semantic or morphosyntactic violations. Given the specificity of the Italian language in which the sequencing of words is relatively more free than in English or other languages, we investigate...

journal_title：Neuroscience letters

authors： Angrilli A,Penolazzi B,Vespignani F,De Vincenzi M,Job R,Ciccarelli L,Palomba D,Stegagno L

更新日期：2002-03-29 00:00:00

abstract：:It has been generally suggested that chewing produces an enhancing effect on cognitive performance-related aspects of memory by the test battery. Furthermore, recent studies have shown that chewing is associated with activation of various brain regions, including the prefrontal cortex. However, little is known about t...

journal_title：Neuroscience letters

authors： Hirano Y,Obata T,Kashikura K,Nonaka H,Tachibana A,Ikehira H,Onozuka M

更新日期：2008-05-09 00:00:00

abstract：:It has been demonstrated that thyroxine deiodinating activity is present in rat pineal gland, and its activity increases significantly during the night time. We have studied whether mRNA for type II iodothyronine deiodinase is expressed in rat pineal gland and whether the nocturnal rise of pineal T4 deiodinating activ...

journal_title：Neuroscience letters

authors： Murakami M,Hosoi Y,Negishi T,Kamiya Y,Ogiwara T,Mizuma H,Yamada M,Iriuchijima T,Mori M

更新日期：1997-05-09 00:00:00

abstract：:Cyclophosphamide (CP) has been used as an antitumour agent or immunosuppressant clinically, though the potential biological role of CP in the central nervous system (CNS) has not been clarified. In the present study, we found that pretreatment with CP prevented neuronal cell death caused by serum deprivation in cultur...

journal_title：Neuroscience letters

authors： Kitazawa H,Numakawa T,Adachi N,Kumamaru E,Tuerxun T,Kudo M,Kunugi H

更新日期：2010-02-12 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS(+)) is a common familial epilepsy syndrome, which generally develops in childhood. GEFS(+) is caused by mutations in the sodium-channel α1-subunit (SCN1A). In this report, we investigated a Chinese family with an autosomal dominant form of GEFS(+). The affected GEF...

journal_title：Neuroscience letters

authors： Cui X,Zeng F,Liu Y,Zhang J,Archacki S,Zhan T,Du R,Tang Z,Liu J,Wang QK,Liu M

更新日期：2011-09-26 00:00:00

abstract：:Using immunohistochemical techniques, we demonstrate aspartate aminotransferase (AAT)-like immunoreactivity in cone pedicles and ganglion cells of the cat retina. An identical pattern was seen when we stained for cytochrome oxidase activity, a marker for neurons which have a high metabolic activity. Tetrodotoxin selec...

journal_title：Neuroscience letters

authors： Bolz J,Thier P,Brecha N

更新日期：1985-02-04 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA), quisqualate, kainate and potassium increased, in a dose-dependent manner, the efflux of radioactivity from rat cerebral cortex minislices preincubated with [3H]choline. Ketamine (1-5 microM) and magnesium (0.1-1 mM) reduced only the release evoked by NMDA. The non-parallel shift of the NMD...

journal_title：Neuroscience letters

authors： Lodge D,Johnston GA

更新日期：1985-05-23 00:00:00

abstract：:Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, wit...

journal_title：Neuroscience letters

authors： Antoniadis A,Müller WE,Wollert U

更新日期：1980-07-01 00:00:00

abstract：:Essentially all animals with nervous systems utilize electrical synapses as a core element of communication. Electrical synapses, formed by gap junctions between neurons, provide rapid, bidirectional communication that accomplishes tasks distinct from and complementary to chemical synapses. These include coordination ...

journal_title：Neuroscience letters

authors： O'Brien J

更新日期：2019-03-16 00:00:00

abstract：:Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Starting from a rat AADC cDNA clone isolated in our laboratory, we produced a beta-galactosidase-AADC fusion protein in E. coli. It was purified from inclusion bodies and injected into a ...

journal_title：Neuroscience letters

authors： Krieger M,Tillet Y,Gros F,Thibault J

更新日期：1993-04-16 00:00:00

abstract：:A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

journal_title：Neuroscience letters

authors： Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

更新日期：2013-10-25 00:00:00

abstract：:In mammals, methyl-CpG binding proteins play a significant role in the control of gene expression through their association with chromatin-remodeling complexes. Mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome and have also been reported in a number of X-linked mental retardati...

journal_title：Neuroscience letters

authors： dos Santos JM,Abdalla CB,Campos M Jr,Santos-Rebouças CB,Pimentel MM

更新日期：2005-04-29 00:00:00

abstract：:In ten patients with Parkinson's disease (PD) and ten age-matched healthy controls, we applied 15 30-s trains of subthreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area. Ten minutes after rTMS, PD patients showed a significant prolongation of the transcranially evoked sil...

journal_title：Neuroscience letters

authors： Siebner HR,Mentschel C,Auer C,Lehner C,Conrad B

更新日期：2000-04-28 00:00:00

abstract：:Viral infections of the central nervous system are often associated with seizures, and while patients usually recover from the infection and the seizures cease, there is an increased lifetime incidence of epilepsy. These viral infections can result in mesial temporal sclerosis, and, subsequently, a type of epilepsy th...

journal_title：Neuroscience letters

authors： Smeal RM,Fujinami R,White HS,Wilcox KS

更新日期：2015-11-16 00:00:00

abstract：:The muscarinic receptor antagonist scopolamine significantly increased the number of errors in the working memory task with a three-panel runway setup, when injected bilaterally at 3.2 micrograms/side into the dorsal hippocampus. The increase in working memory errors induced by intrahippocampal 3.2 micrograms/side sco...

journal_title：Neuroscience letters

authors： Ohno M,Kishi A,Watanabe S

更新日期：1996-10-11 00:00:00

abstract：:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-...

journal_title：Neuroscience letters

authors： Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HM

更新日期：2001-11-02 00:00:00

abstract：:Neuromuscular electrical stimulation (NMES) increases the excitability of corticospinal (CS) pathways by altering circuits in motor cortex (M1). How NMES affects circuits interposed between the ascending afferent volley and descending CS pathways is not known. Presently, we hypothesized that short-latency afferent inh...

journal_title：Neuroscience letters

authors： Mang CS,Bergquist AJ,Roshko SM,Collins DF

更新日期：2012-10-31 00:00:00

abstract：:Complement is implicated in the pathogenesis of inflammatory disorders of the central nervous system (CNS), like multiple sclerosis, Alzheimer's disease, and trauma. The anaphylatoxins C3a and C5a are thought to be the major contributors to complement-mediated inflammation in the CNS, likely mediating their effects vi...

journal_title：Neuroscience letters

authors： Boos L,Szalai AJ,Barnum SR

更新日期：2005-10-21 00:00:00

abstract：:Canine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. Superoxide dismutase 1 (SOD1) mutations have been reported in affected dogs and immunohistochemical analyses revealed the accumulation of mutant SOD1 (E40K) in spinal neurons and astrocytes. Therefore, this disease ...

journal_title：Neuroscience letters

authors： Yokota S,Kobatake Y,Noda Y,Nakata K,Yamato O,Hara H,Sakai H,Nishida H,Maeda S,Kamishina H

更新日期：2018-11-20 00:00:00

abstract：:Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND ...

journal_title：Neuroscience letters

authors： Xia YX,Ikeda T,Xia XY,Ikenoue T

更新日期：2000-02-25 00:00:00

abstract：:Recent studies have shown an association between Parkinson disease (PD) and mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GBA), which is deficient in patients with Gaucher disease. In Asian populations, 2 mutational analysis studies have been performed in all exons of GBA; one study in a Japa...

journal_title：Neuroscience letters

authors： Choi JM,Kim WC,Lyoo CH,Kang SY,Lee PH,Baik JS,Koh SB,Ma HI,Sohn YH,Lee MS,Kim YJ

更新日期：2012-04-11 00:00:00

abstract：:The effects of various Flustra foliacea metabolites on different types of human neuronal nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes were investigated. Whereas most of the compounds tested had a small blocking effect, one of them, deformylflustrabromine, selectively increased the current ob...

journal_title：Neuroscience letters

authors： Sala F,Mulet J,Reddy KP,Bernal JA,Wikman P,Valor LM,Peters L,König GM,Criado M,Sala S

更新日期：2005-01-10 00:00:00