The uptake and transport behavior of berberine in Coptidis Rhizoma extract through rat primary cultured cortical neurons.

abstract：:L1 is a highly conserved cell adhesion molecule with complete homology of the cytoplasmic domain between the known mammalian protein sequences. Since the cytoplasmic domains of other adhesion molecules have been shown to influence adhesion, we have investigated the effects of deletion of the cytoplasmic domain on the ...

journal_title：Neuroscience letters

authors： Wong EV,Cheng G,Payne HR,Lemmon V

更新日期：1995-11-24 00:00:00

abstract：:Neurofibromatosis 1 (NF1) is a common autosomal dominant disorder in which affected individuals develop benign and malignant tumors as well as non-tumor-related abnormalities, such as seizures and learning disabilities. Here, we report an NF1 isoform arising from the alternative splicing of exon 9a with predominant ce...

journal_title：Neuroscience letters

authors： Geist RT,Gutmann DH

更新日期：1996-06-21 00:00:00

abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

journal_title：Neuroscience letters

authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

更新日期：1994-04-25 00:00:00

abstract：:Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are chemogenetic tools commonly-used to manipulate brain activity. The most widely-used synthetic DREADD ligand, clozapine-N-oxide (CNO), is back-metabolized to clozapine which can itself activate endogenous receptors. Studies in non-DREADD-expressin...

journal_title：Neuroscience letters

authors： Tran FH,Spears SL,Ahn KJ,Eisch AJ,Yun S

更新日期：2020-11-20 00:00:00

abstract：:An attempt was made to identify the immunoreactive substance P (SP) released from isolated rat spinal cords using reversed-phase high-performance liquid chromatography (HPLC) combined with radioimmunoassay (RIA) for SP. Soaking the spinal cords of newborn rats in Krebs solution containing 90 mM K+ evoked a release of ...

journal_title：Neuroscience letters

authors： Akagi H,Otsuka M,Yanagisawa M

更新日期：1980-12-01 00:00:00

abstract：:This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

journal_title：Neuroscience letters

authors： Sun Y,Zhou M,Wang D,Chen F,Wang Q,Han X,Cheng W

更新日期：2020-06-24 00:00:00

abstract：:There is evidence that immune-inflammatory, stress of reactive oxygen and nitrogen species (IO&NS) processes play a role in the neurodegenerative processes observed in Parkinson's disease (PD). The aim of the present study was to investigate peripheral IO&NS biomarkers in PD. We included 56 healthy individuals and 56 ...

journal_title：Neuroscience letters

authors： de Farias CC,Maes M,Bonifácio KL,Bortolasci CC,de Souza Nogueira A,Brinholi FF,Matsumoto AK,do Nascimento MA,de Melo LB,Nixdorf SL,Lavado EL,Moreira EG,Barbosa DS

更新日期：2016-03-23 00:00:00

abstract：:This study used ERPs to determine whether older adults use prosody in resolving early and late closure ambiguities comparably to young adults. Participants made off-line acceptability judgments on well-formed sentences or those containing prosody-syntax mismatches. Behaviorally, both groups identified mismatches, but ...

journal_title：Neuroscience letters

authors： Steinhauer K,Abada SH,Pauker E,Itzhak I,Baum SR

更新日期：2010-03-19 00:00:00

abstract：:Previous studies have observed increased tachykinin NK(1) receptor immunoreactivity (NK(1)-IR) in the prefrontal cortex in subjects with schizophrenia. Since the subjects were medicated the possibility of a treatment effect could not be excluded. Thus, the present study was undertaken to determine the effect of chroni...

journal_title：Neuroscience letters

authors： Tooney PA,Anderson WB,Lynch-Frame A,Chahl LA

更新日期：2005-07-22 00:00:00

abstract：:The nitric oxide synthase (NOS) inhibitor L-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1-5; Lee, J.H. et al., NeuroReport, 3 (1992) 841-844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198-202]. We investig...

journal_title：Neuroscience letters

authors： Lam HH,Hanley DF,Trapp BD,Saito S,Raja S,Dawson TM,Yamaguchi H

更新日期：1996-06-07 00:00:00

abstract：:The content of synaptophysin, a vesicular integral membrane protein of neurons and endocrine cells, and that of vasopressin was measured in neurohypophyses of rats during chronic osmotic stimulation. The animals received 2% NaCl in their drinking water for up to 4 days. Synaptophysin content of neurohypophyses was det...

journal_title：Neuroscience letters

authors： Ehrhart-Bornstein M,Thorn NA,Treiman M

更新日期：1990-10-30 00:00:00

abstract：:The possible voltage-dependence of the dopamine transporter (DAT) was investigated using electrophysiological and electrochemical recordings in rat brain slices containing the substantia nigra (SN). Whole-cell patch clamp recordings of DA neurons, revealed that addition of 15 mM KCl rapidly depolarized the membrane po...

journal_title：Neuroscience letters

authors： Hoffman AF,Zahniser NR,Lupica CR,Gerhardt GA

更新日期：1999-01-29 00:00:00

abstract：:The effect of prenatal ethanol exposure on the number of parvalbumin-immunoreactive (PA+) GABAergic neurons in the adult rat anterior cingulate cortex was determined. Pregnant Long-Evans rats were maintained on one of three diets throughout gestation: an ethanol-containing liquid diet, a similar, control liquid diet w...

journal_title：Neuroscience letters

authors： Moore DB,Quintero MA,Ruygrok AC,Walker DW,Heaton MB

更新日期：1998-06-12 00:00:00

abstract：:The functional interaction in the spinal cord between substance P and excitatory amino acid agonists was investigated. Behavioural responses were scored in mice after intrathecal administration of excitatory amino acid agonists and substance P, given separately or in combination. A strong potentiation of the effect wa...

journal_title：Neuroscience letters

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1991-11-25 00:00:00

abstract：:Glucose metabolism and tricarboxylic acid cycle (TCA) kinetics have been shown to decline in brain with age in various animal species. This study examined TCA cycle kinetics and age in Brown-Norway Fischer 344 rats. Using [1-(13)C]glucose infused over 10, 30, 60 or 100 min, and following the label through the TCA cycl...

journal_title：Neuroscience letters

authors： Perron JT,Tyson RL,Sutherland GR

更新日期：2000-03-10 00:00:00

abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained transl...

journal_title：Neuroscience letters

authors： Okuyama-Tamura M,Mikuni M,Kojima I

更新日期：2003-05-22 00:00:00

abstract：:In gastropods, the interneuronal messenger, nitric oxide (NO), modulates spike frequency and synaptic transmission. We have characterized the effect of NO on ion currents underlying neuronal excitability, using current-clamp and two-electrode voltage-clamp techniques. Identified neurons of the pulmonate snail, Helix p...

journal_title：Neuroscience letters

authors： Zsombok A,Schrofner S,Hermann A,Kerschbaum HH

更新日期：2000-12-08 00:00:00

abstract：:The rat spinal cord slice preparation has been used to investigate the sensitivity of deep dorsal horn neurones to the excitatory amino acids N-methyl-D-aspartate (NMDA), quisqualate and L-glutamate. Intracellular recordings were made from 44 neurones in laminae III-VI of 14- to 16-day rats. Superfusion of quisqualate...

journal_title：Neuroscience letters

authors： King AE,Thompson SW,Urban L,Woolf CJ

更新日期：1988-07-08 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

journal_title：Neuroscience letters

authors： Wen X,Westergard T,Pasinelli P,Trotti D

更新日期：2017-01-01 00:00:00

abstract：:Aggression reflects the psychological and physical behavior that perpetrator intends to harm victim. Initiation of aggression is influenced by the distal factors (e.g. personality) and proximate causes (e.g. affect) of perpetrator. However, few studies explored the brain structural basis of relationship between these ...

journal_title：Neuroscience letters

authors： Zhu X,Wang K,Cao A,Zhang Y,Qiu J

更新日期：2020-01-23 00:00:00

abstract：:The vestibular system has widespread interactions with other sensory modalities. Here we investigate whether vestibular stimulation modulates somatosensory function, by assessing the ability to detect faint tactile stimuli to the fingertips of the left and right hand with or without galvanic vestibular stimulation (GV...

journal_title：Neuroscience letters

authors： Ferrè ER,Day BL,Bottini G,Haggard P

更新日期：2013-08-29 00:00:00

abstract：:In a light microscopic study the ferric ion-ferrocyanide staining of the squid giant axon was investigated. In other neurons this stain is known to indicate excitable membranes with high sodium channel density, such as the node of Ranvier or the initial segment. In the squid the stain reacted in small patches of the a...

journal_title：Neuroscience letters

authors： Greeff NG,Akert K,Sandri C

更新日期：1985-06-12 00:00:00

abstract：:In vivo differential pulse voltammetry with carbon fiber electrodes was used to monitor extracellular 5-hydroxyindoleacetic acid (5-HIAA) levels in a serotonergic denervated target area, the striatum, before and after transplantation of mesencephalic raphé nuclei into the lateral ventricle in the rat. The amplitude of...

journal_title：Neuroscience letters

authors： McRae-Degueurce A,Serrano A,Sandillon F,Privat A,Scatton B

更新日期：1984-07-27 00:00:00

abstract：:Using the monoclonal antibody, ME 20.4, against the p75 nerve growth factor (NGF) receptor, NGF receptor-like immunoreactivity has been identified in axonal processes innervating the human hippocampus, where previously a loss of reactivity has been reported in a preliminary study of Alzheimer's disease [10]. In an ext...

journal_title：Neuroscience letters

authors： Kerwin JM,Morris CM,Perry RH,Perry EK

更新日期：1992-08-31 00:00:00

abstract：:RMI 12330A dose-dependently inhibits cAMP accumulation induced by PGE2 in guinea-pig superior cervical ganglion (SCG). Norepinephrine (NE) is unable to modify cAMP concentration in the same preparation. On the other hand, both PGE2 and NE block the firing discharge of guinea-pig SCG neurons elicited by electrical stim...

journal_title：Neuroscience letters

authors： Borasio PG,Ferretti ME,Biondi C,Trevisani A

更新日期：1982-10-08 00:00:00

abstract：:Pitch and duration -- either as written symbols or in auditory form -- are the basic structural properties in tones that form a melodic sequence. From the cognitive perspective, it is still a matter of debate whether, and at which processing stage, these two factors are processed independently or interdependently. The...

journal_title：Neuroscience letters

authors： Neuhaus C,Knösche TR

更新日期：2008-08-15 00:00:00

abstract：:There have been reports of regional differences in the activation of mitogen activated protein kinases (MAPKs) and in the induction of immediate early genes after electroconvulsive shock (ECS) in the rat brain. This study was performed to determine whether ECS induce the region-specific phosphorylation of MAPK-downstr...

journal_title：Neuroscience letters

authors： Ahn YM,Kang UG,Oh SW,Juhnn YS,Joo YH,Park JB,Kim YS

更新日期：2002-08-23 00:00:00

abstract：:Local delivery of cytokines or other immunomodulatory components has been applied as a potential therapy for experimental autoimmune encephalomyelitis (EAE), which is used as a model of human multiple sclerosis. We have used herpes simplex virus-based vectors expressing Th2 cytokines IL-4 and IL-10 and have previously...

journal_title：Neuroscience letters

authors： Broberg EK,Salmi AA,Hukkanen V

更新日期：2004-07-08 00:00:00

abstract：:The 22Na+ efflux stimulated by selected agonists of the 4 excitatory amino acid receptors, previously detected in the striatum, has been studied on 22Na+-preloaded slices prepared from 10 major areas of the rat brain. All brain areas were found to be sensitive, albeit to varying extents, to excitatory amino acids. The...

journal_title：Neuroscience letters

authors： Luini A,Goldberg O,Teichberg VI

更新日期：1983-11-11 00:00:00

abstract：:Melatonin is a tryptophan metabolite synthesized by the pineal gland. Recent research showed that melatonin has a protective effect in Alzheimer's disease (AD). However, its exact mechanism is still unclear. This study was designed to investigate the effects of long-term oral melatonin on spatial learning and memory, ...

journal_title：Neuroscience letters

authors： Sun C,Qiu X,Wang Y,Liu J,Li Q,Jiang H,Li S,Song C

更新日期：2020-09-14 00:00:00