Abstract:
:The effect of prenatal ethanol exposure on the number of parvalbumin-immunoreactive (PA+) GABAergic neurons in the adult rat anterior cingulate cortex was determined. Pregnant Long-Evans rats were maintained on one of three diets throughout gestation: an ethanol-containing liquid diet, a similar, control liquid diet with the isocaloric substitution of sucrose for ethanol, or a lab chow control diet. Offspring were euthanized on postnatal day 60 and brains were prepared for parvalbumin immunocytochemistry. Rats exposed to the ethanol-containing diet contained 45% fewer PA+ neurons in the anterior cingulate cortex compared with sucrose and chow controls. This reduction occurred in the absence of changes in structure volume, and occurred in the absence of changes in PA+ neuronal size.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Moore DB,Quintero MA,Ruygrok AC,Walker DW,Heaton MBdoi
10.1016/s0304-3940(98)00378-4subject
Has Abstractpub_date
1998-06-12 00:00:00pages
25-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00378-4journal_volume
249pub_type
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