Abstract:
:The nitric oxide synthase (NOS) inhibitor L-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1-5; Lee, J.H. et al., NeuroReport, 3 (1992) 841-844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198-202]. We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons. Results showed a bilateral increase in the number of nNOS-positive neurons at the L4-5 dorsal horn area following formalin injection. The increase was always greater on the ipsilateral side compared to the contralateral side. This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lam HH,Hanley DF,Trapp BD,Saito S,Raja S,Dawson TM,Yamaguchi Hdoi
10.1016/0304-3940(96)12702-6subject
Has Abstractpub_date
1996-06-07 00:00:00pages
201-4issue
3eissn
0304-3940issn
1872-7972pii
0304394096127026journal_volume
210pub_type
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