The role of acetate as a potential mediator of the effects of ethanol in the brain.

Abstract:

:Acetate is the primary product of ethanol catabolism and can accumulate in the blood at concentrations of up to 2 mM following ethanol consumption. It has been suggested that some of the pharmacological actions of ethanol are mediated via acetate, which can lead indirectly to the release of endogenous adenosine. In the present experiments this hypothesis was tested by examining the effects of exogenous sodium acetate on the physiology of hippocampal slices from rat brain. Acetate had no significant effect on intracellular responses recorded from CA1 pyramidal neurons or on extracellular field potentials evoked from the either the CA1 region or the dentate gyrus. There was also no significant difference in responses to the adenosine receptor antagonist theophylline in CA1 pyramidal neurons recorded using intracellular filling solutions containing potassium acetate, KCl, or potassium methylsulfate. These results suggest that the presence of acetate, either in the extracellular medium or within an intracellular electrode, does not induce a significant increase in adenosine receptor activation in the hippocampus.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Brundege JM,Dunwiddie TV

doi

10.1016/0304-3940(95)11320-v

subject

Has Abstract

pub_date

1995-02-17 00:00:00

pages

214-8

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)11320-V

journal_volume

186

pub_type

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