Potassium propionate causes preferential loss of 'bound' acetylcholine in frog muscle.

Abstract:

:Bound and free acetylcholine (ACh) were measured in frog sartorius muscles by mass fragmentography. Upon incubation of the muscles for 5 min with potassium propionate, which stimulated the release of ACh, there was a 2-fold reduction of bound ACh. In contrast, the amount of free ACh remained unchanged. After 65 min recovery from stimulation in normal Ringer solution containing deuterium-labelled choline, free ACh was labelled to a higher degree than bound ACh. The results are in agreement with the idea that ACh is synthesized in the cytoplasmic compartment of the motor nerve terminal, and subsequently transferred to the vesicles from which it is released upon stimulation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Molenaar PC,Polak RL

doi

10.1016/0304-3940(83)90189-1

subject

Has Abstract

pub_date

1983-12-30 00:00:00

pages

209-13

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(83)90189-1

journal_volume

43

pub_type

杂志文章
  • Expression of the exon 1A-containing PMP22 transcript is altered in the trembler mouse.

    abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP22) gene which results in an abnormal myelination of its peripheral nervous system. The recent identification of two different PMP22 mRNA differing in their 5' non-translated region led us to monitor their respectiv...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)12008-r

    authors: Garbay B,Boiron-Sargueil F,Cassagne C

    更新日期:1995-10-06 00:00:00

  • Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.

    abstract::The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00010-x

    authors: Mori H,Arai T,Ishii H,Adachi T,Endo N,Makino K,Mori K

    更新日期:1998-01-30 00:00:00

  • Neutrophil extracellular traps increased by hyperglycemia exacerbate ischemic brain damage.

    abstract::Hyperglycemia is common and associated with poor outcome in acute ischemic stroke patients. Neutrophil extracellular traps (NETs) are increased either in diabetes or ischemic stroke. We aimed to determine the role of NETs in acute ischemic stroke with hyperglycemia as it has not been clarified. NETs were observed in t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135383

    authors: Deng J,Zhao F,Zhang Y,Zhou Y,Xu X,Zhang X,Zhao Y

    更新日期:2020-11-01 00:00:00

  • Xenogeneic dopaminergic grafts reverse behavioral deficits induced by 6-OHDA in rodents: effect of 15-deoxyspergualin treatment.

    abstract::Foetal rat mesencephalic dopamine-containing tissue was transplanted into the lateral ventricle of mice previously subjected to a 6-OHDA lesion of dopaminergic nerve terminals in the corpus striatum. The graft recipients were immunosuppressed by subcutaneous injections of 15-deoxyspergualin (DSG). Four weeks postgraft...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90234-c

    authors: Zhou J,Date I,Sakai K,Yoshimoto Y,Furuta T,Asari S,Ohmoto T

    更新日期:1993-11-26 00:00:00

  • Increased erythrocyte susceptibility to lipid peroxidation in human Parkinson's disease.

    abstract::Recent evidence suggests that among the factors that lead to neurodegenerative changes in Parkinson's disease are stimulation of lipid peroxidation and deficiency of glutathione and glutathione peroxidase in substantia nigra. We have investigated the effect of neurodegenerative changes on plasma and erythrocytes of pa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90467-3

    authors: Kilinç A,Yalçin AS,Yalçin D,Taga Y,Emerk K

    更新日期:1988-05-03 00:00:00

  • Topography of nicotinamide adenine dinucleotide phosphate-diaphorase staining neurons in rat striatum.

    abstract::A new modification of the nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase reaction was used to study the distribution of a specific subset of neurons in rat striatum. These neurons are known to also contain somatostatin-like immunoreactivity (SLI). We have previously found a heterogeneous distribution o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90215-0

    authors: Kowall NW,Beal MF,Ferrante RJ,Martin JB

    更新日期:1985-08-16 00:00:00

  • Pulvinar participates in synchronizing neural assemblies in the visual cortex, in cats.

    abstract::It has been proposed that the perception of a coherent image necessitates two processes, that is, an ensemble of neurons which synchronizes discharges of individual cells and stimulus-specific gamma-band (gamma) neuronal oscillations which may serve as carrier signals for a temporal code. We tested the hypothesis that...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00497-8

    authors: Shumikhina S,Molotchnikoff S

    更新日期:1999-09-10 00:00:00

  • Soybean agglutinin binding to the olfactory systems of the rat and mouse.

    abstract::The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90591-4

    authors: Key B,Giorgi PP

    更新日期:1986-08-29 00:00:00

  • Responses of regional cerebral blood flow to intravenous administration of thyrotropin releasing hormone in aged rats.

    abstract::The effects of i.v. administration of thyrotropin releasing hormone (TRH) on regional cerebral blood flow (rCBF) were examined in both healthy adult (3-5 months old) and healthy aged (24-25 months old) male Wistar rats under halothane anesthesia. The rCBFs in 9 different brain regions-cerebral cortex, caudate putamen,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90254-5

    authors: Inanami O,Ohno K,Sato A

    更新日期:1992-08-31 00:00:00

  • Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits.

    abstract::The febrile responses induced by i.v. administrations of staphylococcal enterotoxin A (SEA) was mimicked by direct injection of SEA into the organum vasculosum laminae terminalis (OVLT) in unanesthetized rabbits. Compared with the febrile responses induced by i.v. injection of SEA, the OVLT route of injection required...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00759-3

    authors: Huang WT,Lin MT,Won SJ

    更新日期:1997-10-24 00:00:00

  • Wnt-3a improves functional recovery through autophagy activation via inhibiting the mTOR signaling pathway after spinal cord injury.

    abstract::Little is known about the effect of wnt-3a on motor nerve function and its specific molecular mechanisms after spinal cord injury (SCI). This study demonstrates that the downregulated expression levels of caspases-3, caspases-9 and chondroitin sulfate proteoglycan (CSPG) proteins and number of proportion of transferas...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135305

    authors: Gao K,Niu J,Dang X

    更新日期:2020-10-15 00:00:00

  • Group II metabotropic glutamate receptor-mediated activation of G-proteins in rat hippocampal and striatal membranes.

    abstract::Stimulation of G-proteins coupled with metabotropic glutamate receptors (mGlu receptors) was investigated by means of guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS) binding assay in rat hippocampal and striatal membranes. The endogenous ligand l-glutamate increased specific [(35)S]GTPγS binding in a concent...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.01.033

    authors: Odagaki Y,Kinoshita M,Toyoshima R

    更新日期:2013-02-28 00:00:00

  • Immunocytochemical localization of endopeptidase-24.11 in the nucleus tractus solitarius of the rat brain.

    abstract::Recently, it has been hypothesized that the N-terminal portion of substance P (SP), SP(1-7), which results from the action of endopeptidase 24.11 (EC3.4.24.11), could be involved in mediating the depressor effects of baroreceptor afferent activation via its action on cells in the nucleus tractus solitarius (NTS). In t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90117-r

    authors: Lasher RS,Lutz EM,Mulholland F,Sanderson R,Stewart JM,Bublitz C

    更新日期:1990-09-04 00:00:00

  • Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI.

    abstract::The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.02.081

    authors: Zhou Y,Liang M,Jiang T,Tian L,Liu Y,Liu Z,Liu H,Kuang F

    更新日期:2007-05-07 00:00:00

  • Immunocytochemical demonstration of astrocytes and microglia in the whale brain.

    abstract::Whale brains have attracted the attention of neuroscientists but there are only sparse studies on whale glial cells. Here we report on immunolabeling of astrocytes by antibodies to glial fibrillary acidic protein (GFAP) or protein S-100 beta (both by the streptavidin/biotin technique), and labeling of microglial cells...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)91027-8

    authors: Pritz-Hohmeier S,Härtig W,Behrmann G,Reichenbach A

    更新日期:1994-02-14 00:00:00

  • The effects of cortical ablation on mastication in the rabbit.

    abstract::To verify the hypothesis that the control of movement by the cortical masticatory area (CMA) is particularly important at the beginning of the mastication, we compared movements before and after bilateral CMA ablation. After ablation, the animal could not manipulate food placed in the front of the mouth for several da...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90122-4

    authors: Enomoto S,Schwartz G,Lund JP

    更新日期:1987-11-23 00:00:00

  • Alteration of dopamine D1 receptor in the strionigral system of the postischemic rat brain.

    abstract::Chronological changes of dopamine D1 receptor binding were determined in the strionigral system of the rat brain by using [3H]SCH 23390, a highly selective dopamine D1 antagonist, in vitro autoradiography after 90 min of right middle cerebral artery (MCA) occlusion and after such occlusion followed by different period...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90533-d

    authors: Nagasawa H,Araki T,Kogure K

    更新日期:1992-01-06 00:00:00

  • A novel mutation (Cys6Gly) in the Cu/Zn superoxide dismutase gene associated with rapidly progressive familial amyotrophic lateral sclerosis.

    abstract::Autosomal-dominant familial amyotrophic lateral sclerosis (FALS) is associated with mutation in the gene that encodes Cu/Zn superoxide dismutase (SOD1). We identified a novel missense mutation of SOD-1 (Cys6Gly) in exon 1 in a Japanese woman and her family. The illness showed rapid progression similarly to the FALS wi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00803-4

    authors: Kohno S,Takahashi Y,Miyajima H,Serizawa M,Mizoguchi K

    更新日期:1999-12-03 00:00:00

  • Melatonin infusions restore sleep suppressed by continuous bright light in pigeons.

    abstract::Constant bright light (LL) suppresses 24-h melatonin and many other behavioral and physiological rhythms in pigeons. LL also strongly suppresses sleep. Daily melatonin infusions in LL restore sleep to normal nocturnal levels of a light-dark cycle and continuous infusions sustain it for at least 10 days. Restoration of...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90026-4

    authors: Phillips NH,Berger RJ

    更新日期:1992-10-12 00:00:00

  • Intracellular recordings from two cell types in an in vitro preparation of the salamander olfactory epithelium.

    abstract::Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane po...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90527-x

    authors: Masukawa LM,Kauer JS,Shepherd GM

    更新日期:1983-01-31 00:00:00

  • Informational constraints in human precision aiming.

    abstract::Twelve human subjects performed a reciprocal precision aiming task of varying difficulty (index of difficulty=4, 5, or 6) while vision of the ongoing movement was available either continuously or intermittently. In the intermittent conditions, vision of the moving end-effector was available at regular intervals (equal...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)01003-0

    authors: Bootsma RJ,Boulard M,Fernandez L,Mottet D

    更新日期:2002-11-22 00:00:00

  • Fibers of trigeminal mesencephalic neurons in the maxillary nerve of the rat.

    abstract::Indirect Wallerian degeneration after sectioning the infraorbital nerve, and retrograde axonal transport following injection of horseradish peroxidase (HRP) into the maxillary nerve were studied in rats. These experiments showed the existence of primary trigeminal neurons in the pars caudalis of the ipsilateral trigem...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90333-x

    authors: Gonzálo-Sanz LM,Insausti R

    更新日期:1980-02-01 00:00:00

  • Topographical distribution of pinprick and warmth thresholds to CO2 laser stimulation on the human skin.

    abstract::We studied the topographical distribution of laser sensory thresholds on the human hairy skin, using a small laser beam for pinprick and a large beam for warmth sensations. The threshold for pinprick sensation correlated positively with the distance from the brain, suggesting that Adelta nociceptors, the fibers which ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01038-7

    authors: Agostino R,Cruccu G,Iannetti G,Romaniello A,Truini A,Manfredi M

    更新日期:2000-05-12 00:00:00

  • Human brain potentials to reading syntactic errors in sentences of different complexity.

    abstract::In order to determine if an event-related brain potential (ERP) effect described for syntactic violations (P600/SPS) varies with the amount of reprocessing entailed by a violation, number incongruencies were presented either within simple declarative or within subordinate clauses. ERPs were recorded while 12 German su...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0304-3940(97)00719-2

    authors: Münte TF,Szentkuti A,Wieringa BM,Matzke M,Johannes S

    更新日期:1997-10-17 00:00:00

  • Effect of extracts of injured nerve on initiating the regenerative response in the hypoglossal nucleus in the rat.

    abstract::The uptake of 2-deoxy-[14C]glucose (2-DG) by motor neurons in adult rat hypoglossal nuclei was studied 3 days after subepineural injection of 'crude' soluble protein extracts from intact and injured peripheral nerves into normal hypoglossal nerves. Injured nerve extracts were obtained from 'proximal' and 'distal' segm...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90400-4

    authors: Singer PA,Mehler S,Fernandez HL

    更新日期:1988-01-22 00:00:00

  • DNA versus RNA oxidation in Parkinson's disease: Which is more important?

    abstract:BACKROUND:8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurod...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.09.048

    authors: Gmitterová K,Gawinecka J,Heinemann U,Valkovič P,Zerr I

    更新日期:2018-01-01 00:00:00

  • Design principles of electrical synaptic plasticity.

    abstract::Essentially all animals with nervous systems utilize electrical synapses as a core element of communication. Electrical synapses, formed by gap junctions between neurons, provide rapid, bidirectional communication that accomplishes tasks distinct from and complementary to chemical synapses. These include coordination ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2017.09.003

    authors: O'Brien J

    更新日期:2019-03-16 00:00:00

  • The oxytocin antagonist 1-deamino-2-D-Tyr-(Oet)-4-Thr-8-Orn-oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats.

    abstract::In this study the effect of exogenous oxytocin and of massage-like stroking on the withdrawal latency responses to heat and mechanical nociceptive stimulation were investigated in rats. A hot-plate test and the Randall-Selitto test were used to assess the withdrawal responses. Exogenous oxytocin (0.1-1 mg/kg) and stro...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11335-t

    authors: Agren G,Lundeberg T,Uvnäs-Moberg K,Sato A

    更新日期:1995-02-24 00:00:00

  • Coexistence of substance P and calcitonin gene-related peptide in the frog spinal cord.

    abstract::The localization of substance P (SP) and calcitonin gene-related peptide (CGRP) was studied in the untreated spinal cord of the frog using single or double immunohistochemical stainings. SP and CGRP appear to coexist in the primary afferent fibers and in the marginal and submarginal dorsal horn zones, as well as in th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90462-9

    authors: Venesio T,Mulatero B,Fasolo A

    更新日期:1987-10-05 00:00:00

  • Roles of NF-kappaB and MAPK signaling pathways in morphological and cytoskeletal responses of microglia to double-stranded RNA.

    abstract::Following virus infection of the central nervous system, microglia become activated and undergo morphological as well as functional transformations, thereby initiating effective antiviral actions. Herein, we have examined the contribution of nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK)...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.12.058

    authors: Nakamichi K,Saiki M,Kitani H,Kuboyama Y,Morimoto K,Takayama-Ito M,Kurane I

    更新日期:2007-03-13 00:00:00