Abstract:
:The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP22) gene which results in an abnormal myelination of its peripheral nervous system. The recent identification of two different PMP22 mRNA differing in their 5' non-translated region led us to monitor their respective levels of expression in the trembler peripheral nervous system (PNS) during the myelination period. We showed that the steady-state levels of the exon 1A-containing transcript, which is thought to be involved in the myelination process, were greatly reduced in heterozygous and homozygous trembler mice when compared to the normal animals. Such a difference was not observed for the exon 1B-containing transcript. Therefore, our results support the idea that the two alternatively used promoters of the PMP22 gene are under different regulation control, and that the up-regulation of the exon 1A-transcript is necessary for the normal myelination of the mouse PNS.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Garbay B,Boiron-Sargueil F,Cassagne Cdoi
10.1016/0304-3940(95)12008-rsubject
Has Abstractpub_date
1995-10-06 00:00:00pages
157-60issue
3eissn
0304-3940issn
1872-7972pii
030439409512008Rjournal_volume
198pub_type
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