RET-RGS, a retina-specific regulator of G-protein signaling, is located in synaptic regions of the rat retina.

abstract：:Cancer patients with bone metastases often suffer breakthrough pain. However, little progress has been made in the treatment of breakthrough pain and its associated mechanism(s) in the patient with cancer due to lacking of resembling and predictive animal models. We previously have demonstrated that endothelin-1 plays...

journal_title：Neuroscience letters

authors： Tang Y,Peng H,Liao Q,Gan L,Zhang R,Huang L,Ding Z,Yang H,Yan X,Gu Y,Zang X,Huang D,Cao S

更新日期：2016-03-23 00:00:00

abstract：:The effects of the normotensive, mainly centrally active nitric oxide synthase (NOS) inhibitor 7-nitro indazole and the hypertensive drug NG-nitro-L-arginine, which blocks both the endothelial and the central NOS, have been examined on naloxone-precipitated withdrawal in morphine-dependent rats. Both drugs attenuated ...

journal_title：Neuroscience letters

authors： Cappendijk SL,Duval SY,de Vries R,Dzoljic MR

更新日期：1995-01-02 00:00:00

abstract：:The effects of long-term exposure of primary cultured rat dorsal root ganglion (DRG) cells to bradykinin (BK), compared to short-term exposure, were investigated to establish whether BK could induce prostaglandin E2 (PGE2) release from DRG cells. Short-term exposure (30 min) resulted in a small but significant amount ...

journal_title：Neuroscience letters

authors： Inoue A,Iwasa M,Nishikura Y,Ogawa S,Nakasuka A,Nakata Y

更新日期：2006-07-03 00:00:00

abstract：:Neuronal nAChRs are pentameric transmembrane proteins which function as ligand-gated ion channels and are composed of multiple alpha and beta subunits. Nine neuronal nAChR alpha subunit genes (alpha2-alpha10) and three nAChR beta subunit genes (beta2-beta4) have been identified. nAChR subtypes are heteromers, composed...

journal_title：Neuroscience letters

authors： Danthi S,Boyd RT

更新日期：2006-05-29 00:00:00

abstract：:To test the hypothesis that the expression of specific proteins on peripheral terminals of primary afferents can be attenuated by intrathecal administration of antisense oligodeoxynucleotides (ODNs), we administered ODNs antisense to the mu-opioid receptor to male Sprague-Dawley rats via chronically implanted intrathe...

journal_title：Neuroscience letters

authors： Khasar SG,Gold MS,Dastmalchi S,Levine JD

更新日期：1996-10-25 00:00:00

abstract：:A cDNA clone encoding a novel protein (Cer-1) was isolated from a mouse cerebellar cDNA library. The deduced amino acid sequence of Cer-1 is not homologous to other sequences in the protein sequence data base. RNA blot analysis suggests that expression of Cer-1 RNA occurs selectively in the adult cerebellum and in pur...

journal_title：Neuroscience letters

authors： Bulleit RF,Lin X,Jeppi JV

更新日期：1996-05-10 00:00:00

abstract：:Tonsils have a privileged situation in the immune system in that they are in touch with the environment. Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system. We have studied a group of thirty five children with recurrent acute tonsil...

journal_title：Neuroscience letters

authors： Lopez-Gonzalez MA,Guerrero JM,Sanchez B,Delgado F

更新日期：1998-05-15 00:00:00

abstract：:beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

journal_title：Neuroscience letters

authors： Zeevalk GD,Nicklas WJ

更新日期：1989-07-31 00:00:00

abstract：:Using in situ hybridization, the mRNA levels encoding neuropeptide Y (NPY) was investigated in the arcuate nucleus (ARC) of jerboas under three different states of energy balance. (1) normally feeding animals, (2) hibernating animals and finally (3) animals food deprived for 5 days. The hibernating and food deprived j...

journal_title：Neuroscience letters

authors： El Ouezzani S,Lafon P,Tramu G,Magoul R

更新日期：2001-06-08 00:00:00

abstract：:A comparison of the effect of fatigue caused by electrical induction or voluntary contraction on Ia inhibition in human soleus muscle was investigated in fourteen healthy male subjects. The Hoffmann reflex (H reflex) was employed to elucidate the contribution of fatigue induced contraction to the Ia inhibition. A stat...

journal_title：Neuroscience letters

authors： Tsuboi T,Sato T,Egawa K,Miyazaki M

更新日期：1995-09-01 00:00:00

abstract：:The psychophysiological basis of problem size effect in the arithmetical processing of additions and subtractions was studied with event-related brain potentials (ERP). Subjects were presented sequences of seven numbers, and ERPs elicited to the sixth number were analyzed. Two variables were manipulated: operation typ...

journal_title：Neuroscience letters

authors： Núñez-Peña MI,Honrubia-Serrano ML,Escera C

更新日期：2005-01-03 00:00:00

abstract：:The development of supersensitivity to dopamine by striatal neurons is widely considered to be a response to interruption of dopaminergic synaptic function. However, it is not clear whether pre-existing dopaminergic innervation is in fact necessary for supersensitivity to develop. In this study, rat foetal striatal ce...

journal_title：Neuroscience letters

authors： Guerra MJ,Liste I,Rozas G,Tobio J,Labandeira-Garcia JL

更新日期：1996-03-15 00:00:00

abstract：:The effect of the R(-) and S(+) isomers of 3,4-methylenedioxyamphetamine (MDA) and its N-methyl analog 3,4-methylenedioxymethamphetamine (MDMA) on [3H]inositol monophosphate accumulation was studied in cells expressing either 5-HT2A or 5-HT2C receptors. The isomers of MDA produced a concentration dependent increase in...

journal_title：Neuroscience letters

authors： Nash JF,Roth BL,Brodkin JD,Nichols DE,Gudelsky GA

更新日期：1994-08-15 00:00:00

abstract：:Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highe...

journal_title：Neuroscience letters

authors： Ortega GJ,Sola RG,Pastor J

更新日期：2008-12-12 00:00:00

abstract：:The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...

journal_title：Neuroscience letters

authors： Grigsby KB,Kovarik CM,Rottinghaus GE,Booth FW

更新日期：2018-04-03 00:00:00

abstract：:gamma-Aminobutyric acidA (GABA(A)) gated chloride ion channels were expressed from human recombinant cDNA using the baculovirus/Sf-9 insect cell expression system. The electrophysiological effects in whole-cell currents of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, were investigated on...

journal_title：Neuroscience letters

authors： Westh-Hansen SE,Noguchi K,Witt MR,Murai Y,Nielsen M,Akaike N

更新日期：1997-07-11 00:00:00

abstract：:Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimul...

journal_title：Neuroscience letters

authors： Kamphuis W,Gorter JA,Wadman WJ,Lopes da Silva FH

更新日期：1992-07-06 00:00:00

abstract：:The level of endogenous nerve growth factor (NGF) in rat sciatic nerve was determined using a highly sensitive two-site enzyme immunoassay. After crushing this nerve NGF accumulated linearly distal to the crush during the first 12 h to reach levels 13-fold higher than in the uncrushed contralateral side. In contrast, ...

journal_title：Neuroscience letters

authors： Korsching S,Thoenen H

更新日期：1983-08-19 00:00:00

abstract：:Viral infections of the central nervous system are often associated with seizures, and while patients usually recover from the infection and the seizures cease, there is an increased lifetime incidence of epilepsy. These viral infections can result in mesial temporal sclerosis, and, subsequently, a type of epilepsy th...

journal_title：Neuroscience letters

authors： Smeal RM,Fujinami R,White HS,Wilcox KS

更新日期：2015-11-16 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:We studied the trophic effects of various neuropeptides, including substance P (SP), thyrotropin-releasing hormone (TRH), neurotensin (NT) and bombesin (BN) on explanted cultures of ventral spinal cord from 13- to 14-day-old rat embryos. In groups, receiving one type of drug only, there was a significant neurite-promo...

journal_title：Neuroscience letters

authors： Iwasaki Y,Kinoshita M,Ikeda K,Takamiya K,Shiojima T

更新日期：1989-07-03 00:00:00

abstract：:Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with...

journal_title：Neuroscience letters

authors： Atmaca M,Yavuzkir M,Mermi O,Topuz M,Kanmaz E,Tezcan E

更新日期：2008-09-05 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) can be activated by opioids such as morphine via opioid receptor, and their activations have been observed in synaptic plasticity, learning, memory and addiction. Long-term exposure to morphine may induce physical dependence, manifested as somatic withdrawal symptoms such as di...

journal_title：Neuroscience letters

authors： Li T,Hou Y,Cao W,Yan CX,Chen T,Li SB

更新日期：2010-01-14 00:00:00

abstract：:The localization of cells which produce estrogen receptors in the rat central nervous system was performed using an in situ hybridization technique. For this, we used a synthetic oligonucleotide probe labeled with 35S complementary to the mRNA coding for a fragment (1-24) of estradiol receptor which is not common to t...

journal_title：Neuroscience letters

authors： Pelletier G,Liao N,Follea N,Govindan MV

更新日期：1988-11-22 00:00:00

abstract：:Recently, a mitogen activated protein kinase has been implicated in the generation of a phosphorylated paired helical filament (PHF) epitope recognized by the monoclonal antibody AT8. This epitope consists of phosphorylated serines 199 and/or 202 of the human microtubule associated protein tau. Theoretically, aside fr...

journal_title：Neuroscience letters

authors： Vandermeeren M,Lübke U,Six J,Cras P

更新日期：1993-04-16 00:00:00

abstract：:The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultu...

journal_title：Neuroscience letters

authors： Li RX,Yu XZ,Fu M,Zong M,Liu RL,Xie ZP

更新日期：2008-08-15 00:00:00

abstract：:There is controversy as to what extent the processing of spectrally rich sounds in the human auditory cortex is related to the processing of singular frequencies. An informative index of the function of the auditory cortex, particularly important in neurological patients, is the mismatch negativity (MMN), a component ...

journal_title：Neuroscience letters

authors： Kotchoubey B,Lang S,Herb E,Maurer P,Schmalohr D,Bostanov V,Birbaumer N

更新日期：2003-12-04 00:00:00

abstract：:Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorde...

journal_title：Neuroscience letters

authors： Prendes-Alvarez S,Nemeroff CB

更新日期：2018-03-16 00:00:00

abstract：:Human amniotic epithelial (HAE) cells have been used for allotransplantation in patients with lysosomal storage disease due to lack of expression of HLA antigens. Previously, we have reported the expression of differentiation markers for both neural stem cells, and neuron and glial cells. In the present study, we inve...

journal_title：Neuroscience letters

authors： Sakuragawa N,Misawa H,Ohsugi K,Kakishita K,Ishii T,Thangavel R,Tohyama J,Elwan M,Yokoyama Y,Okuda O,Arai H,Ogino I,Sato K

更新日期：1997-08-22 00:00:00

abstract：:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801)...

journal_title：Neuroscience letters

authors： Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

更新日期：1993-10-01 00:00:00