Abstract:
:Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimulation intensity was found in CA1. A similar change was found in the fascia dentata in response to medium intensity stimulation of the angular bundle. In contrast, at high intensity, paired pulse depression was enhanced in the fascia dentata in the course of kindling. These results indicate that kindling epileptogenesis is accompanied by regionally different changes in recurrent inhibition: a reduction in CA1 and intensity dependent changes in fascia dentata.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kamphuis W,Gorter JA,Wadman WJ,Lopes da Silva FHdoi
10.1016/0304-3940(92)90344-7keywords:
subject
Has Abstractpub_date
1992-07-06 00:00:00pages
101-5issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90344-7journal_volume
141pub_type
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