Abstract：
:We studied the trophic effects of various neuropeptides, including substance P (SP), thyrotropin-releasing hormone (TRH), neurotensin (NT) and bombesin (BN) on explanted cultures of ventral spinal cord from 13- to 14-day-old rat embryos. In groups, receiving one type of drug only, there was a significant neurite-promoting effect (NPE) in SP, TRH and BN-treated cultures. At a concentration of 10(-12) M the most potent effect was shown by SP. However, BN had the most potent action at concentrations greater than 10(-10) M. It also became clear that there were maximum and minimum effective concentrations for these 3 neuropeptides. NT had no NPE at any concentration. There was no additional NPE when any two or all four of these neuropeptides were given simultaneously. Our results demonstrate that BN, SP, and TRH have a trophic effect on ventral spinal cord in cultures, and may contribute to a therapeutic strategy in amyotrophic lateral sclerosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Iwasaki Y,Kinoshita M,Ikeda K,Takamiya K,Shiojima Tdoi
10.1016/0304-3940(89)90552-1subject
Has Abstractpub_date
1989-07-03 00:00:00pages
316-20issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90552-1journal_volume
101pub_type
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pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：1987-07-22 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：
更新日期：1996-09-06 00:00:00
