Abstract：
:The neuron-specific phosphoprotein B-50 is a major substrate of kinase C in fetal nerve growth cones, neonatal neural and synaptosomal plasma membranes. B-50 is identical to a growth-associated protein GAP43. Similarly, increases in B-50 occur during rat brain development, neuronal differentiation and axon regeneration. To document the relation between the expression of B-50 and the outgrowth of central axons, we studied B-50 in the developing pyramidal tract in rats at postnatal days 2, 7 and 90 (P2, P7 and P90), at the third cervical spinal segment C3, using affinity-purified antibodies to B-50. At P2 and P7, when outgrowth of pyramidal tract fibers is occurring, B-50 immunoreactivity (BIR) is intense in these fibers. BIR is reduced from P2 to P7 in the ascending fiber tracts of the cuneatus and the gracilis, which develop earlier. At P90 when most of the dorsal funiculus fibers have reached their targets and many are myelinated, BIR is dramatically reduced. In agreement, a 10-fold decrease in B-50 content was measured at P90, as compared to P7. Therefore, our results indicate that B-50 is only expressed relatively abundant in axons of the funiculus posterior during outgrowth. By inference, B-50 may be a differentiating marker to detect elongating fibers.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gorgels TG,Oestreicher AB,de Kort EJ,Gispen WHdoi
10.1016/0304-3940(87)90216-3subject
Has Abstractpub_date
1987-12-16 00:00:00pages
59-64issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90216-3journal_volume
83pub_type
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.06.066
更新日期：2012-08-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1997-03-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-09-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90698-2
更新日期：1988-09-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1996-07-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90512-x
更新日期：1987-06-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.01.075
更新日期：2015-03-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90588-k
更新日期：1991-12-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.05.043
更新日期：2009-08-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1998-12-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.01.065
更新日期：2007-04-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2017.08.005
更新日期：2018-01-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1999-03-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90582-4
更新日期：1988-03-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2011-01-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1985-05-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90322-4
更新日期：1989-09-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.03.013
更新日期：2005-07-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90661-1
更新日期：1988-12-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90426-3
更新日期：1983-11-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.04.076
更新日期：2010-07-12 00:00:00
abstract：:The ability of three nitric oxide (NO) donor compounds to modify ligand binding to kainate receptors was studied in tissue from human adult autopsy brains. Binding of [3H]kainic acid (5 nM) was measured in frontal cortex membranes made from Brodmann area 8 (BA 8) and autoradiographically using sections of frontal cort...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00654-x
更新日期：1997-09-19 00:00:00
