Abstract：
:The ability of three nitric oxide (NO) donor compounds to modify ligand binding to kainate receptors was studied in tissue from human adult autopsy brains. Binding of [3H]kainic acid (5 nM) was measured in frontal cortex membranes made from Brodmann area 8 (BA 8) and autoradiographically using sections of frontal cortex (BA 8 and 9). None of the three donors, S-nitroso-N-acetyl-D,L-penicillamine (SNAP), S-nitrosocysteine (Cys-NO) and 3-morpholinosydnonimine chloride (SIN-1) altered the specific binding of [3H]kainic acid. Nitrite accumulation assays confirmed that adequate amounts of NO were released by the donors under the ligand binding conditions used. The findings show that binding to the kainate receptor, in contrast to the other ionotropic glutamate receptors, is not affected by NO and strongly suggest that endogenous NO produced by NO synthase (NOS) does not modulate kainate receptors in vivo. Mechanisms whereby NOS inhibitors potentiate kainic acid-induced seizures in animal models may include altered modulation of glutamate N-methyl-D-aspartate (NMDA) receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lees RD,Slater P,D'Souza SWdoi
10.1016/s0304-3940(97)00654-xsubject
Has Abstractpub_date
1997-09-19 00:00:00pages
133-6issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00654-Xjournal_volume
233pub_type
杂志文章abstract：:Using the monoclonal antibody, ME 20.4, against the p75 nerve growth factor (NGF) receptor, NGF receptor-like immunoreactivity has been identified in axonal processes innervating the human hippocampus, where previously a loss of reactivity has been reported in a preliminary study of Alzheimer's disease [10]. In an ext...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90242-y
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-01-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2000-06-09 00:00:00
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journal_title：Neuroscience letters
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更新日期：1996-03-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2012-07-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1986-03-28 00:00:00
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journal_title：Neuroscience letters
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更新日期：2014-02-21 00:00:00
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1979-01-01 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1987-03-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.02.065
更新日期：2005-07-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1999-06-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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