Abstract:
:C57 black mice given a single injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 40 mg/kg, developed marked reduction of striatal dopamine content and loss of dopaminergic neurons in the zona compacta of the substantia nigra. However, pretreatment with any one of four different antioxidants, alpha-tocopherol, beta-carotene, ascorbic acid or N-acetylcysteine, significantly decreased MPTP-induced striatal dopamine loss, and alpha-tocopherol prevented neuronal loss in the substantia nigra. Four chemical analogues of MPTP (cinnamaldehyde, N,N-dimethylcinnamylamine, arecoline and 2-methyl-1,2,3,4-tetrahydro-6,7-isoquinolinediol) were all found to lack dopaminergic nigrostriatal neurotoxicity in the mouse.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Perry TL,Yong VW,Clavier RM,Jones K,Wright JM,Foulks JG,Wall RAdoi
10.1016/0304-3940(85)90229-0subject
Has Abstractpub_date
1985-09-30 00:00:00pages
109-14issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(85)90229-0journal_volume
60pub_type
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