Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration.


:Growth/differentiation factor-5 (GDF-5), a member of the transforming growth factor-beta (TGF-β) superfamily, has been shown to protect rat dopaminergic neurons against insult both in embryonic neuronal culture and in Parkinson's disease models. However, whether GDF-5 exerts neuroprotective effects in hippocampal neurons is unclear. Here, we show that both mRNA levels and protein levels of GDF-5 are decreased in the mouse hippocampus upon kainic acid (KA) treatment. KA induced dramatic neuronal loss specifically in the cornu ammonis 1 (CA1) and CA3 areas of the mouse hippocampus, while intracerebral infusion of GDF-5 prevented this neuronal loss. The neuroprotective effects of GDF-5 were recapitulated by constitutively active bone morphogenetic protein type IB receptor (BMPRIB-CA) and could be blocked by BMPRI kinase inhibitor LDN-193189. Furthermore, the neuroprotective effects of GDF-5 were mediated through the prevention of apoptosis, which was indicated by terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) staining and reduced cleaved caspase 3 expression level. Thus, we conclude that GDF-5 protects hippocampal neurons against KA-induced neurodegeneration by signaling through BMPRIB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases.


Neurosci Lett


Neuroscience letters


Zhao Y,Zhang M,Liu H,Wang J




Has Abstract


2017-06-09 00:00:00












  • Heroin-based crack induces hyperalgesia through β-arrestin 2 redistribution and phosphorylation of Erk1/2 and JNK in the periaqueductal gray area.

    abstract::Continuous use of crack induces hyperalgesia which is related to drug tolerance. Despite cumulative evidence based on the growth rate of crack abuse, no serious study has been focused on the mechanisms of crack-induced hyperalgesia. This study aimed to elucidate whether extracellular signal-regulated kinases (Erk1/2)/...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Aberoumandi SM,Vousooghi N,Tabrizi BA,Karimi P

    更新日期:2019-04-17 00:00:00

  • Neural correlates of delayed episodic memory in patients with mild cognitive impairment--a FDG PET study.

    abstract::Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease (AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Schönknecht OD,Hunt A,Toro P,Henze M,Haberkorn U,Schröder J

    更新日期:2009-12-25 00:00:00

  • Crossed thalamo-cortical and cortico-thalamic projections in adult mice.

    abstract::The crossed thalamo-cortical and cortico-thalamic connections of the mouse are drawn using the tracer wheat germ agglutinin-horseradish peroxidase. After injections in the frontal cortex of the right hemisphere cells labeled retrogradely and axons labeled anterogradely are observed in the thalamus ipsilateral and cont...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Carretta D,Sbriccoli A,Santarelli M,Pinto F,Granato A,Minciacchi D

    更新日期:1996-02-02 00:00:00

  • Axotomy induces MHC class I antigen expression on rat nerve cells.

    abstract::Immunomorphological staining demonstrates that class I major histocompatibility complex (MHC)-coded antigen expression can be selectively induced on otherwise class I-negative rat nerve cells by peripheral axotomy. Induction of class I as well as class II antigen expression was simultaneously seen on non-neural cells ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Maehlen J,Schröder HD,Klareskog L,Olsson T,Kristensson K

    更新日期:1988-09-23 00:00:00

  • Ultrastructural characteristics of circadian pacemaker neurones, immunoreactive to an antibody against a pigment-dispersing hormone in the fly's brain.

    abstract::Neurones immunoreactive to an antibody against a pigment-dispersing hormone (PDH-ir) are considered to be pacemaker cells in the neuronal circadian system of flies. We investigated the ultrastructure of PDH-ir varicosities, possible releasing sites of the PDH-like peptide, in the distal medulla of the optic lobe and i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Miskiewicz K,Pyza E,Schürmann FW

    更新日期:2004-06-03 00:00:00

  • N400 as an index of uncontrolled categorization processing in brand extension.

    abstract::This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Wang X,Ma Q,Wang C

    更新日期:2012-09-06 00:00:00

  • Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population.

    abstract::Recent studies have shown an association between Parkinson disease (PD) and mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GBA), which is deficient in patients with Gaucher disease. In Asian populations, 2 mutational analysis studies have been performed in all exons of GBA; one study in a Japa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Choi JM,Kim WC,Lyoo CH,Kang SY,Lee PH,Baik JS,Koh SB,Ma HI,Sohn YH,Lee MS,Kim YJ

    更新日期:2012-04-11 00:00:00

  • Leucine-enkephalin-like immunoreactive afferent fibers to pudendal motoneurons in the cat.

    abstract::Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

    更新日期:1985-10-24 00:00:00

  • Reticular premotor neurons projecting to both facial and hypoglossal nuclei receive trigeminal afferents in rats.

    abstract::The distribution of premotor neurons projecting to motor nuclei of both the VIIth (VII) and XIIth (XII) nerves was examined in the pontomedullary reticular formation (RF) of the rat by using retrograde double labeling. After injection of two different tracers in the VII and the XII, most of the double labeled neurons ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dauvergne C,Pinganaud G,Buisseret P,Buisseret-Delmas C,Zerari-Mailly F

    更新日期:2001-09-28 00:00:00

  • Visualisation of catecholamine-fluorescent nerve cell bodies in the rat brain after colchicine treatment.

    abstract::Central administration of colchicine causes accumulation of catecholamines in nerve cell bodies and enhances their visualisation in the rat brain by the formaldehyde-glutaraldehyde (FAGLU) histofluorescence method. The detection of catecholamine-containing nerve cells by the FAGLU method was considerably improved in r...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Howe PR,Rogers PF,Blessing WW

    更新日期:1984-12-21 00:00:00

  • Immunochemical and immunohistochemical characterization of a synaptic membrane protein that binds the competitive antagonists of NMDA receptors.

    abstract::An approximately 54-kDa protein that has binding sites for the competitive N-methyl-D-aspartate (NMDA) receptor antagonists 3-((+-)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) and (+-)-(E)-2-amino-4-propyl-5-phosphonopentenoic acid (CGP 39653) was purified from rat brain synaptic membranes. Polyclonal ant...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Eggeman KT,Pal R,Walsh J,Kumar KN,Michaelis EK

    更新日期:1993-08-20 00:00:00

  • Lucifer Yellow labeling of embryonic chick retinal amacrine cells in vitro.

    abstract::Lucifer Yellow (LY) selectively labels embryonic chick amacrine cells from days 11 until 14 in vivo. Its usefulness as an in vitro marker was investigated. In vivo labeling and subsequent culturing was not possible due to dye leakage. Neurons, however, could be labeled at various times in vitro. The number of neurons ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zeevalk GD,Hyndman AG

    更新日期:1986-03-14 00:00:00

  • Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators.

    abstract::This study investigated differences in brain activation during meditation between meditators and non-meditators. Fifteen Vipassana meditators (mean practice: 7.9 years, 2h daily) and fifteen non-meditators, matched for sex, age, education, and handedness, participated in a block-design fMRI study that included mindful...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Hölzel BK,Ott U,Hempel H,Hackl A,Wolf K,Stark R,Vaitl D

    更新日期:2007-06-21 00:00:00

  • A single evoked afterdischarge produces rapid time-dependent changes in connexin36 protein expression in adult rat dorsal hippocampus.

    abstract::Gap junctions between neurons contribute to synchronous neuronal firing and may play a role in the pathophysiology of epilepsy. We examined the expression of a number of gap junction subunits, including the neuronal gap junction forming protein connexin36 (Cx36), in the hippocampus at various time points following an ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: McCracken CB,Roberts DC

    更新日期:2006-09-11 00:00:00

  • The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.

    abstract::The epsilon4 allele of the apolipoprotein E gene (APOE) has repeatedly been associated with increased risk for Alzheimer's disease (AD). Bullido and colleagues recently identified a polymorphism in the promoter region of the APOE gene (-491A/T) and found that -491A homozygosity predicted AD independently of APOE epsil...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Town T,Paris D,Fallin D,Duara R,Barker W,Gold M,Crawford F,Mullan M

    更新日期:1998-08-14 00:00:00

  • Peripheral neuropathy and object length perception by effortful (dynamic) touch: a case study.

    abstract::The spatial extents of hand-held objects can be perceived nonvisually by wielding them. This ability of effortful or dynamic touch to exploit the mass moments of an object to perceive its length was evaluated with a 40-years old right-handed woman with surgically treated Arnold-Chiari Type 1 Malformation and cervical ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Carello C,Kinsella-Shaw J,Amazeen EL,Turvey MT

    更新日期:2006-09-25 00:00:00

  • Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats.

    abstract::Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet. Seladin-1 is an enzyme cata...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kazkayasi I,Ismail MA,Parrado-Fernandez C,Björkhem I,Pekiner C,Uma S,Cedazo-Minguez A,Burul-Bozkurt N

    更新日期:2016-10-28 00:00:00

  • Mortality in gerbils with repetitive ischemia: CGSGS-19755/hypothermia therapy.

    abstract::Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was off...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: McCrea S,Shuaib A,Wishart T,Ijaz S

    更新日期:1994-03-28 00:00:00

  • Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra.

    abstract::Iron mediated oxidative stress is known to contribute to the neurodegenerative process in Parkinson's disease (PD). Although there are hints that genes involved in brain iron metabolism might be involved in the pathogenesis of PD in some instances, it is still not known whether the increase in brain iron content const...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Akbas N,Hochstrasser H,Deplazes J,Tomiuk J,Bauer P,Walter U,Behnke S,Riess O,Berg D

    更新日期:2006-10-16 00:00:00

  • Conditioned medium of dental pulp cells stimulated by Chinese propolis show neuroprotection and neurite extension in vitro.

    abstract::The purpose of this study was to clarify the effect of Chinese propolis on the expression level of neurotrophic factors in dental pulp cells (DPCs). We also investigated that the effects of the conditioned medium (CM) of DPCs stimulated by the propolis against oxidative and endoplasmic reticulum (ER) stresses in human...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kudo D,Inden M,Sekine S,Tamaoki N,Iida K,Naito E,Watanabe K,Kamishina H,Shibata T,Hozumi I

    更新日期:2015-03-04 00:00:00

  • Long-lasting FosB/DeltaFosB immunoreactivity in the rat brain after repeated cat odor exposure.

    abstract::Cat odor elicits defensive responses in rats that are modified by repeated exposure to the odor. We explored the neural correlates of this adaptation using FosB/DeltaFosB immunohistochemistry. Rats were given 3 x60 min exposures to either a worn cat collar (repeated cat odor group) or unworn cat collar (control group)...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Staples LG,McGregor IS,Hunt GE

    更新日期:2009-09-22 00:00:00

  • The relationship between childhood aerobic fitness and brain functional connectivity.

    abstract::Several studies have indicated that higher levels of childhood aerobic fitness is associated with superior cognitive function, and this association is disproportionately observed in tasks requiring greater top-down control. We designed the current study to clarify the relationship between childhood fitness and top-dow...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kamijo K,Takeda Y,Takai Y,Haramura M

    更新日期:2016-10-06 00:00:00

  • Non-rapid-eye-movement sleep propensity after sleep deprivation in human subjects.

    abstract::The circadian modulation of occurrence of non-rapid-eye-movement sleep (NREM) was investigated in 37 volunteers under dim-light conditions after 24-h total sleep deprivation using a 26-h 10/20-min ultra-short sleep-wake schedule. The propensity of NREM showed rapid increase followed by gradual decrease during the subj...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tagaya H,Uchiyama M,Shibui K,Kim K,Suzuki H,Kamei Y,Okawa M

    更新日期:2002-04-19 00:00:00

  • Association of the CR1 polymorphism with late-onset Alzheimer's disease in Chinese Han populations: a meta-analysis.

    abstract::It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,meta分析


    authors: Jin C,Li W,Yuan J,Xu W,Cheng Z

    更新日期:2012-10-03 00:00:00

  • Expression of neuronal isoform of nitric oxide synthase in spinal neurons of neonatal rats after sciatic nerve transection.

    abstract::Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and exam...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Rogério F,Teixeira SA,de Souza Queiroz L,De Nucci G,Langone F

    更新日期:2001-07-13 00:00:00

  • Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat.

    abstract::The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Liu H,Llewellyn-Smith IJ,Pilowsky P,Basbaum AI

    更新日期:1992-04-13 00:00:00

  • Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions.

    abstract::By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus w...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ohgami T,Kitamoto T,Tateishi J

    更新日期:1992-02-17 00:00:00

  • Binding of omega-conotoxin to receptor sites associated with the voltage-sensitive calcium channel.

    abstract::The binding of radioiodinated omega-conotoxin GVIA, a probable Ca channel antagonist, to synaptic plasma membranes of rat brain was examined. Two kinds of specific binding sites were found with apparent dissociation constants of 10 pM and 0.5 nM and maximum binding capacities of 0.5 and 3.4 pmol/mg prot., respectively...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Abe T,Koyano K,Saisu H,Nishiuchi Y,Sakakibara S

    更新日期:1986-11-11 00:00:00

  • The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder.

    abstract::To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in p...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章


    authors: Lu R,Zhang C,Liu Y,Wang L,Chen X,Zhou X

    更新日期:2018-09-25 00:00:00

  • Chemokine inhibition in rat stab wound brain injury using antisense oligodeoxynucleotides.

    abstract::Traumatic injury to the central nervous system (CNS) results in the breakdown of the blood-brain barrier and recruitment of hematogenous cells at the site of injury. The role of chemokines in this process has been well recognized and they have been regarded as promising targets for development of anti-inflammatory the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ghirnikar RS,Lee YL,Li JD,Eng LF

    更新日期:1998-05-08 00:00:00