Abstract：
:C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of beta-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by beta-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ma ZG,Wang J,Jiang H,Xie JX,Chen Ldoi
10.1016/j.neulet.2005.02.065keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
102-5issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00267-3journal_volume
382pub_type
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