Abstract:
:Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the alpha subunit of the Go protein (Goalpha) in cerebral cortex and cerebellum from rats that have chronically ingested ethanol, by using immunoblotting and pertussis toxin-catalyzed ADP-ribosylation experiments. Goalpha protein levels were increased in plasma membranes from the two brain areas, and this increase was shown to specifically affect Go1alpha, one of the two isoforms of the Goalpha subunit. Results obtained here lead us to suggest that increased Go1alpha in plasma membranes would counteract a modified and non-functional protein generated during chronic alcohol treatment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Guillén A,García-Villafranca J,Mata F,Homburger V,Castro Jdoi
10.1016/j.neulet.2003.09.035keywords:
subject
Has Abstractpub_date
2003-12-26 00:00:00pages
177-80issue
3eissn
0304-3940issn
1872-7972pii
S0304394003011285journal_volume
353pub_type
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