Effect of chronic alcohol consumption on Go protein in rat brain.

Abstract:

:Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the alpha subunit of the Go protein (Goalpha) in cerebral cortex and cerebellum from rats that have chronically ingested ethanol, by using immunoblotting and pertussis toxin-catalyzed ADP-ribosylation experiments. Goalpha protein levels were increased in plasma membranes from the two brain areas, and this increase was shown to specifically affect Go1alpha, one of the two isoforms of the Goalpha subunit. Results obtained here lead us to suggest that increased Go1alpha in plasma membranes would counteract a modified and non-functional protein generated during chronic alcohol treatment.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Guillén A,García-Villafranca J,Mata F,Homburger V,Castro J

doi

10.1016/j.neulet.2003.09.035

keywords:

subject

Has Abstract

pub_date

2003-12-26 00:00:00

pages

177-80

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394003011285

journal_volume

353

pub_type

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