Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

abstract：:In order to clarify the participation of substance P in the expression of opiate withdrawal, we have investigated the effects induced by the new selective neurokinin-1 antagonist RP 67580 on naloxone-induced morphine withdrawal syndrome in rats. Intracerebroventricular administration of RP 67580 elicited a decrease in...

journal_title：Neuroscience letters

authors： Maldonado R,Girdlestone D,Roques BP

更新日期：1993-06-25 00:00:00

abstract：:In the neuritic plaques of Alzheimer's disease, abnormal neuritic processes cluster around a core of beta-amyloid protein. Previous data have shown that beta 1-28, a peptide homologous to the first 28 amino acid residues of beta-amyloid protein, enhanced survival without affecting neuritic extension or branching in cu...

journal_title：Neuroscience letters

authors： Whitson JS,Glabe CG,Shintani E,Abcar A,Cotman CW

更新日期：1990-03-14 00:00:00

abstract：:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migratio...

journal_title：Neuroscience letters

authors： Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

更新日期：2009-02-20 00:00:00

abstract：:A previous study suggested that adults with greater motor difficulties demonstrated less adaptation under a regular error feedback schedule (gain=1:1) but reached a similar level of adaptation compared to controls when feedback was enhanced (gain=1:2). In light of these findings, the present study examined inter-limb ...

journal_title：Neuroscience letters

authors： Bo J,Lee CM

更新日期：2017-07-27 00:00:00

abstract：:Effective treatments to improve survivability following exposure to the nerve agent soman have been established and are currently available. Unfortunately, electrographic brain seizures, neuroinflammation and brain cell death are still a potential problem even with treatment. In the present study we have characterized...

journal_title：Neuroscience letters

authors： Williams AJ,Berti R,Yao C,Price RA,Velarde LC,Koplovitz I,Schultz SM,Tortella FC,Dave JR

更新日期：2003-10-09 00:00:00

abstract：:Synthetic soluble Aβ oligomers are often used as a surrogate for biologic material in a number of model systems. We compared the activity of Aβ oligomers (synthetic and cell culture media derived) on the human SH-SY5Y neuroblastoma and C2C12 mouse myoblast cell lines in a novel, modified MTT assay. Separating oligomer...

journal_title：Neuroscience letters

authors： Weidner AM,Housley M,Murphy MP,Levine H 3rd

更新日期：2011-06-15 00:00:00

abstract：:Harmonically rich sounds have been shown to be processed more efficiently by the human brain compared to single sinusoidal tones. To control for stimulus complexity as a potentially confounding factor, tones and equally complex spectrally rotated sounds, have been used in the present study to investigate the role of t...

journal_title：Neuroscience letters

authors： Christmann CA,Lachmann T,Berti S

更新日期：2014-10-03 00:00:00

abstract：:The human rhabdomyosarcoma cell line TE671 expresses the foetal subtype of muscle acetylcholine receptor (AChR). By transfecting TE671 cells with cDNA encoding the human muscle AChR epsilon subunit under the control of the cytomegalovirus promoter we have established a stable cell clone that, in addition, constitutive...

journal_title：Neuroscience letters

authors： Beeson D,Amar M,Bermudez I,Vincent A,Newsom-Davis J

更新日期：1996-03-22 00:00:00

abstract：:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...

journal_title：Neuroscience letters

authors： Morrisett RA

更新日期：1994-02-14 00:00:00

abstract：:The effect of aconitine, a plant alkaloid known to bind at site 2 of the sodium channel, was investigated on neuronal excitability in hippocampal slices of adult and juvenile rats. Aconitine (0.01-1 microM) diminished the extracellularly recorded population spike in a concentration-dependent manner. At each concentrat...

journal_title：Neuroscience letters

authors： Ameri A

更新日期：1996-09-20 00:00:00

abstract：:The dorsal visual processing stream that includes V1, motion sensitive area V5 and the posterior parietal lobe, supports visually guided motor function. Two recent studies have reported associations between global motion perception, a behavioural measure of processing in V5, and motor function in pre-school and school...

journal_title：Neuroscience letters

authors： Thompson B,McKinlay CJD,Chakraborty A,Anstice NS,Jacobs RJ,Paudel N,Yu TY,Ansell JM,Wouldes TA,Harding JE,CHYLD Study Team.

更新日期：2017-09-29 00:00:00

abstract：:Glutamatergic system, the main stimulating system of the brain, plays an important role in the pathogenesis of schizophrenia. Hippocampus, a structure crucial for memory and cognitive functions and rich in glutamatergic neurons, is a natural object of interest in studies on psychoses. Sarcosine, a glycine transporter ...

journal_title：Neuroscience letters

authors： Strzelecki D,Podgórski M,Kałużyńska O,Gawlik-Kotelnicka O,Stefańczyk L,Kotlicka-Antczak M,Gmitrowicz A,Grzelak P

更新日期：2015-10-08 00:00:00

abstract：:The present study was designed to investigate the role of the interaction of pentobarbital with gamma-aminobutyric acid (GABA)ergic drugs acting on the Cl(-)-adenosine triphosphate (ATP)ase activity of the plasma membranes fraction of bream brain. The preincubation and then incubation of the membranes with pentobarbit...

journal_title：Neuroscience letters

authors： Menzikov S,Menzikova O

更新日期：2002-12-16 00:00:00

abstract：:To identify choline acetyltransferase (ChAT) transcript(s) in human foetal brain we used the reverse polymerase chain reaction including different couples of oligonucleotide primers. The analysis indicated the presence of a new choline acetyltransferase transcript containing at its 5' end an untranslated exon (E1A) of...

journal_title：Neuroscience letters

authors： Schmitt M,Garnier JM,Simoni P,Quirin-Stricker C

更新日期：1994-09-12 00:00:00

abstract：:Vertical arm pointing movements in two directions (upwards and downwards), imposing two different loads (unload and 0.5 kg) and speeds (normal and fast) have been studied in six subjects. Movements were recorded using an optoelectronic system. Data analysis concentrated upon finger-tip kinematics. Significant effects ...

journal_title：Neuroscience letters

authors： Papaxanthis C,Pozzo T,Stapley P

更新日期：1998-09-04 00:00:00

abstract：:A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (alpha, beta, gamma) with unknown stoichiometry. Plasmids containing the rat GABAA receptor cDNAs coding for alpha 1, beta 2, and gamma 2 were co-transfected, along with a plasmid en...

journal_title：Neuroscience letters

authors： Hamilton BJ,Lennon DJ,Im HK,Im WB,Seeburg PH,Carter DB

更新日期：1993-04-30 00:00:00

abstract：:An analysis was made of primary afferent and dorsal horn neuron responses to stimulation of genitalia of female cats. Three types of primary afferents responded to vaginal probing. The most common type responded maximally to the on- and off-ramps of non-noxious pressure applied directly to the clitoris. A second type ...

journal_title：Neuroscience letters

authors： Price DD,Bushnell MC,Iadarola MJ

更新日期：1981-10-01 00:00:00

abstract：:A digoxigenin-labeled antisense 42-mer oligonucleotide was used for the localization of the dopamine D2 receptor mRNA in the rat brain. The digoxigenin label was identified with alkaline phosphatase conjugated sheep-anti-digoxigenin. In good analogy with the known terminal fields of the dopaminergic system, various nu...

journal_title：Neuroscience letters

authors： Brouwer N,Van Dijken H,Ruiters MH,Van Willigen JD,Ter Horst GJ

更新日期：1992-08-17 00:00:00

abstract：:8-Hydroxy-2-[di-n-propylamino]-tetralin) (8-OH-DPAT), a 5-HT1A/7 receptor agonist, has a chronobiological effect on the circadian system. To identify how the 8-OH-DPAT exerts this effect, we specifically destroyed the serotonergic (5-HT) fibres connecting the median raphe nuclei (RN) to the suprachiasmatic nuclei (SCN...

journal_title：Neuroscience letters

authors： Schuhler S,Saboureau M,Pitrosky B,Pévet P

更新日期：1998-10-30 00:00:00

abstract：:A possible role of the human cerebellum in the generation of verbs corresponding to presented nouns has been suggested. Previous functional brain imaging studies have compared generation of verbs with the reading of nouns as a measure of verb generation. In the present fMRI study involving healthy human subjects, the ...

journal_title：Neuroscience letters

authors： Frings M,Dimitrova A,Schorn CF,Elles HG,Hein-Kropp C,Gizewski ER,Diener HC,Timmann D

更新日期：2006-11-27 00:00:00

abstract：:This study was aimed to determine the effect of unilateral hippocampal inactivation on spatial memory retrieval in male and female Wistar rats. Subjects were chronically implanted with a stainless-steel cannula that enabled unilateral intrahippocampal injections of tetrodotoxin, a sodium channel blocker. Rats were tra...

journal_title：Neuroscience letters

authors： Cimadevilla JM,Arias JL

更新日期：2008-07-04 00:00:00

abstract：:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manne...

journal_title：Neuroscience letters

authors： Lymperopoulos A,Karkoulias G,Koch WJ,Flordellis CS

更新日期：2006-07-24 00:00:00

abstract：:Intracellular recordings were used to examine the mechanisms underlying the 5-hydroxytryptamine (5-HT)4 receptor-mediated depolarization seen in CA1 region pyramidal cells in in vitro hippocampal brain slices. This depolarization was mimicked and occluded by administration of the membrane permeable cyclic adenosine mo...

journal_title：Neuroscience letters

authors： Chapin EM,Haj-Dahmane S,Torres G,Andrade R

更新日期：2002-05-10 00:00:00

abstract：:A peptide consisting of residues 25-35 of the amyloid beta protein was applied to single neurons while monitoring membrane current by whole cell voltage clamp recording. Within minutes of direct exposure of a neuron to the amyloid beta peptide, a paroxysmal increase in neuronal membrane conductance was observed. This ...

journal_title：Neuroscience letters

authors： Simmons MA,Schneider CR

更新日期：1993-02-19 00:00:00

abstract：:Previous in vivo studies have indicated that both arginine vasopressin (AVP) and angiotensin II (ANG II) can modulate the baroreflex by acting on the area postrema (AP). In the present study, effects of AVP and ANG II on AP neuronal activity were investigated by recording extracellular activity in a rabbit brainstem s...

journal_title：Neuroscience letters

authors： Cai Y,Bishop VS

更新日期：1995-05-05 00:00:00

abstract：:The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute-lethal (dl) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5-triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial ro...

journal_title：Neuroscience letters

authors： Takagishi Y,Oda S,Hayasaka S,Dekker-Ohno K,Shikata T,Inouye M,Yamamura H

更新日期：1996-09-13 00:00:00

abstract：:To study the neuronal mechanism of a conditioned taste-aversion (CTA) learning in the pond snail Lymnaea stagnalis, we examined the synaptic connection between the neuron 1 medial (N1M) cell and the cerebral giant cell (CGC), the former is an interneuron in central pattern generator for the feeding response and the la...

journal_title：Neuroscience letters

authors： Kojima S,Nanakamura H,Nagayama S,Fujito Y,Ito E

更新日期：1997-07-25 00:00:00

abstract：:Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline response...

journal_title：Neuroscience letters

authors： Stone TW,Taylor DA

更新日期：1979-01-01 00:00:00

abstract：:Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

journal_title：Neuroscience letters

authors： Beattie MS,Bresnahan JC,Mawe GM,Finn S

更新日期：1987-04-23 00:00:00

abstract：:Neuron production carries on throughout adult life in granule cell layer of mammalian dentate gyrus. The acquisition of a hippocampus-dependent task enhances newborn cell survival in granule cell layer (GCL) during the period in which several newborn cells die. In this paper the effect of learning, occurring after the...

journal_title：Neuroscience letters

authors： Ambrogini P,Orsini L,Mancini C,Ferri P,Ciaroni S,Cuppini R

更新日期：2004-04-08 00:00:00