The dilute-lethal (dl) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice.

abstract：:It has been shown that the incidence of cognitive impairment increases with the severity of chronic kidney disease (CKD). A previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in CKD model mice. Endoplasmic reticulum (ER) stress is thought to contribute significantly ...

journal_title：Neuroscience letters

authors： Kosuge Y,Osada N,Shimomura A,Miyagishi H,Wada T,Ishige K,Shimba S,Ito Y

更新日期：2018-06-11 00:00:00

abstract：:This study was designed to investigate the effects of honokiol, a neuroprotective agent, on cerebral edema in cerebral ischemia reperfusion (IR) mice and its mechanism of anti-inflammation. Honokiol (0.7-70μg/kg) significantly reduced brain water contents and decreased the exudation of Evans blue dye from brain capill...

journal_title：Neuroscience letters

authors： Zhang P,Liu X,Zhu Y,Chen S,Zhou D,Wang Y

更新日期：2013-02-08 00:00:00

abstract：:Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sproutin...

journal_title：Neuroscience letters

authors： You J,Hong SQ,Zhang MY,Zhao HL,Liu TZ,Zhou HL,Cai YQ,Xu ZM,Guo Y,Jiang XD,Xu RX

更新日期：2012-09-13 00:00:00

abstract：:A late hyperpolarization (LH) which follows low level to moderate synaptic stimulation of neurons in the hippocampal formation neurons was previously shown to consist primarily of a potassium conductance. The present experiments showed that when extracellular cesium was present in order to reduce anamolous rectificati...

journal_title：Neuroscience letters

authors： Thalmann RH

更新日期：1984-04-20 00:00:00

abstract：:The effects of tetrahydro-9-aminoacridine (THA) on beta-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presenc...

journal_title：Neuroscience letters

authors： Wang SJ,Huang CC,Hsu KS,Tsai JJ,Huang CC,Gean PW

更新日期：1996-08-23 00:00:00

abstract：:Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

journal_title：Neuroscience letters

authors： Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

更新日期：2005-12-30 00:00:00

abstract：:The interaction between ATP-activated channels and the nicotinic receptor-channels has been reported in neuronal cells. To elucidate the mechanisms underlying the interaction, the currents activated by ATP and acetylcholine (ACh) were recorded from cell-free membrane patches excised from rat sympathetic neurons. When ...

journal_title：Neuroscience letters

authors： Nakazawa K,Inoue K

更新日期：1993-11-26 00:00:00

abstract：:Oxytoxin (OT) promotes social behavior and reduces anxiety. A great number of studies suggest that OT plays a role in learning and memory processes in animals and humans. Fear memories are rendered labile and prone to modification after reactivation and a restabilization and reconsolidation process is necessary for fu...

journal_title：Neuroscience letters

authors： Hou Y,Zhao L,Zhang G,Ding L

更新日期：2015-05-06 00:00:00

abstract：:The levels of immunoreactive Leu-enkephalin (ir-Leu-Enk) were measured in acid extract of hearts and lungs of adult normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Heart contents in ir-Leu-Enk were significantly higher in SHR rats (2.67 pmol/g) than in WKY rats (1.5 pmol/g). However, no sign...

journal_title：Neuroscience letters

authors： Dumont M,Lemaire S

更新日期：1988-11-22 00:00:00

abstract：:The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...

journal_title：Neuroscience letters

authors： Paine S,Bedford L,Thorpe JR,Mayer RJ,Cavey JR,Bajaj N,Sheppard PW,Lowe J,Layfield R

更新日期：2009-09-04 00:00:00

abstract：:The distribution and cellular localisation of somatostatin receptor subtype 4 (SSTR4) was investigated in the adult rat brain using the technique of in situ hybridisation with subtype specific oligonucleotide probes. Somatostatin receptor subtype 4 was found mainly in the hippocampus CA1 > CA2 > CA3 pyramidal cells an...

journal_title：Neuroscience letters

authors： Harrington KA,Schindler M,Humphrey PP,Emson PC

更新日期：1995-03-16 00:00:00

abstract：:A new modification of the nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase reaction was used to study the distribution of a specific subset of neurons in rat striatum. These neurons are known to also contain somatostatin-like immunoreactivity (SLI). We have previously found a heterogeneous distribution o...

journal_title：Neuroscience letters

authors： Kowall NW,Beal MF,Ferrante RJ,Martin JB

更新日期：1985-08-16 00:00:00

abstract：BACKGROUND:Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese populatio...

journal_title：Neuroscience letters

authors： Gao T,Zheng R,Ruan Y,Fang Y,Jin C,Cao J,Song Z,Tian J,Pu J,Zhang B

更新日期：2020-09-14 00:00:00

abstract：:The modification of tuning properties in the cochlea has been studied by means of tuning curves from auditory nerve fibers in kittens of various ages. Comparison of tuning curves of three characteristic frequencies (CF) shows that the tuning of high CF units tends to approach adult values by the end of the second post...

journal_title：Neuroscience letters

authors： Romand R

更新日期：1983-03-14 00:00:00

abstract：:In the present study we have used slice cultures of hippocampus and in situ hybridization techniques in order to study the ability of hippocampal neurons to synthesize CCK mRNA in the absence of extrinsic afferents. Our results show that very similar types of hippocampal neurons express CCK mRNA in culture as in situ....

journal_title：Neuroscience letters

authors： Straube A,Bender R,Otten U,Frotscher M

更新日期：1994-05-19 00:00:00

abstract：:Little is known about the metabolic process of tau and tau-derived substances. Alz-50- and tau 2-immunoreactivities in intracellular granules of neurons were observed in regions surrounding infarcted foci in the human cerebral cortex. Ultrastructurally, these granules in the fresh infarcted region exhibited primary ly...

journal_title：Neuroscience letters

authors： Ikeda K,Akiyama H,Arai T,Kondo H,Haga C,Tsuchiya K,Yamada S,Murayama S,Hori A

更新日期：2000-04-28 00:00:00

abstract：:Selective loss of central dopaminergic neurons in vitro and in vivo can be initiated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) through its metabolite phenylpyridium ion (MPP+). Such MPTP-mediated cytotoxicity can be blocked by (-)-Deprenyl, a monoamine oxidase (MAO)-B inhibitor, but the exact mechanisms o...

journal_title：Neuroscience letters

authors： Le W,Jankovic J,Xie W,Kong R,Appel SH

更新日期：1997-03-21 00:00:00

abstract：:Both autoradiographic and horseradish peroxidase tracing techniques were used to characterize a projection from the dorsal lateral geniculate (DLG) nucleus of the thalamus to visual association cortex (extrastriate cortex) in the macaque monkey. The results show that medium to large caliber DLG axons end to discontinu...

journal_title：Neuroscience letters

authors： Yoshida K,Benevento LA

更新日期：1981-03-10 00:00:00

abstract：:Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskoli...

journal_title：Neuroscience letters

authors： Meeker RB,Michels KM,Hayward JN

更新日期：1990-07-03 00:00:00

abstract：:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channe...

journal_title：Neuroscience letters

authors： Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

更新日期：1994-11-07 00:00:00

abstract：:The affective meaning of words can be quantified statistically by the 'semantic differential technique'. We studied a total of 55 Chinese adults in two experiments: first, 210 nouns were rated by 32 subjects. Factor analysis on these data yielded three independent semantic dimensions. Semantically unique words were us...

journal_title：Neuroscience letters

authors： Skrandies W,Chiu MJ

更新日期：2003-04-24 00:00:00

abstract：:Alterations of 'peripheral-type' benzodiazepine receptors (PTBRs) in brain are a feature of hepatic encephalopathy (HE). Although ammonia toxicity has been implicated in the disorder, recent findings suggest an accumulation of manganese in the brains of cirrhotic patients dying in hepatic coma. In this study, we exami...

journal_title：Neuroscience letters

authors： Hazell AS,Desjardins P,Butterworth RF

更新日期：1999-08-13 00:00:00

abstract：:Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic aff...

journal_title：Neuroscience letters

authors： Pierotti AR,Simpson J

更新日期：1986-01-30 00:00:00

abstract：:The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. The aim of present study was to investigate the association between 5-HTTLPR and 5-HT2C Cys23Ser variants and susceptibility to bipolar I disorder (BID). The 5-HT2C genotypes were stud...

journal_title：Neuroscience letters

authors： Mohammadi S,Khazaie H,Rahimi Z,Vaisi-Raygani A,Zargooshi N,Rahimi Z

更新日期：2015-03-17 00:00:00

abstract：:Mood stabilizers are a category of medications used in the management of mood disorders. The mood stabilizing properties of lithium were first reported in 1949 by John Cade, and since then it has been considered the first line treatment for bipolar disorder. Despite presenting more differences than similarities, mood ...

journal_title：Neuroscience letters

authors： Pisanu C,Papadima EM,Del Zompo M,Squassina A

更新日期：2018-03-16 00:00:00

abstract：:Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R injury. However, its role in cerebral I/R remains elu...

journal_title：Neuroscience letters

authors： Liu Y,Guo Y

更新日期：2021-01-19 00:00:00

abstract：:Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. The aim of our study was to prove this result in a comparative clinical study with ...

journal_title：Neuroscience letters

authors： Kiefer F,Jahn H,Otte C,Nakovics H,Wiedemann K

更新日期：2006-08-14 00:00:00

abstract：:Cyclosporine A (CsA) is the major immunosuppressive drug used for organ and neural transplantation and the therapy of selected autoimmune diseases. We investigated the effect of CsA on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia. AChE was determined spectro...

journal_title：Neuroscience letters

authors： Herink J,Krejcová G,Bajgar J,Svoboda Z,Kvĕtina J,Zivnú P,Palicka V

更新日期：2003-03-27 00:00:00

abstract：:It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline...

journal_title：Neuroscience letters

authors： Chen HS,Wang JX,Zhang JH,Li FP,Qu F,Liu BJ,Li M,Lu Y

更新日期：2013-02-08 00:00:00

abstract：:This work investigates the design of a new method to evaluate the importance of visual elements taken into account by a handball goalkeeper facing a thrower. Virtual reality was used to design and reproduce standardised situations in a controlled environment. Under such conditions, it was possible to isolate for inves...

journal_title：Neuroscience letters

authors： Bideau B,Multon F,Kulpa R,Fradet L,Arnaldi B,Delamarche P

更新日期：2004-11-30 00:00:00