Abstract：
:The interaction between ATP-activated channels and the nicotinic receptor-channels has been reported in neuronal cells. To elucidate the mechanisms underlying the interaction, the currents activated by ATP and acetylcholine (ACh) were recorded from cell-free membrane patches excised from rat sympathetic neurons. When ATP or ACh (30-300 microM) was applied, the current consisting of multiple channels was observed in most outside-out patches. The amplitude of the ATP-activated current and that of the ACh-activated current in the same patches were highly correlated (r = 0.89). In a part of the patches, the current activated by ACh (300 microM) with ATP (300 microM) was smaller than the current successively activated by ACh alone, indicating that ATP did not add the current but rather inhibited the ACh-activated channels. In addition, the decay of the current activated by ACh with ATP was faster than the current activated by ACh alone. The coexistence of the two types of channels in the same patches and the interaction of ATP with the ACh-activated current in the cell-free condition may support our previous hypothesis, namely, the activation by ATP of a subpopulation of the nicotinic receptor-channels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nakazawa K,Inoue Kdoi
10.1016/0304-3940(93)90238-gsubject
Has Abstractpub_date
1993-11-26 00:00:00pages
97-100issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90238-Gjournal_volume
163pub_type
杂志文章abstract：:Macrophage migration inhibitory factor (MIF) has been rediscovered as a hormone and immunomodulator as well as a proinflammatory cytokine. We investigated the expression of MIF protein and mRNA in the rat brain using optimized immunohistochemistry and in situ hybridization, respectively. By immunohistochemical analysi...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1993-11-12 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1993-05-14 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：2007-03-13 00:00:00
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journal_title：Neuroscience letters
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更新日期：1995-02-09 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1997-12-12 00:00:00
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更新日期：2001-05-04 00:00:00
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更新日期：1999-08-13 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1997-07-11 00:00:00
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journal_title：Neuroscience letters
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更新日期：2008-12-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2008-08-15 00:00:00
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journal_title：Neuroscience letters
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更新日期：1994-01-31 00:00:00
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journal_title：Neuroscience letters
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更新日期：2019-03-23 00:00:00
