Abstract:
:It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline on BV-induced PSN, mechanical hyperalgesia and inflammatory swelling. Pre-treatment with intrathecal administration of minocyline at different doses significantly inhibited BV-induced PSN and mechanical hyperalgesia, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal microglia may play a key role in BV-induced nociception, but not inflammation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chen HS,Wang JX,Zhang JH,Li FP,Qu F,Liu BJ,Li M,Lu Ydoi
10.1016/j.neulet.2012.11.028subject
Has Abstractpub_date
2013-02-08 00:00:00pages
301-5eissn
0304-3940issn
1872-7972pii
S0304-3940(12)01485-1journal_volume
534pub_type
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